MAGE-Like 2 Proteins (MAGEL2)

MAGEL2 is a member of the MAGEA gene family. Additionally we are shipping MAGE-Like 2 Antibodies (45) and many more products for this protein.

list all proteins Gene Name GeneID
MAGEL2 54551
Rat MAGEL2 MAGEL2 679875
MAGEL2 27385
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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days

MAGEL2 Proteins by Origin and Source

Origin Expressed in Conjugate

Mouse (Murine)

More Proteins for MAGE-Like 2 (MAGEL2) Interaction Partners

Human MAGE-Like 2 (MAGEL2) interaction partners

  1. Immunohistochemistry using D2-40 monoclonal antibody (MAGE2) and anti-MITF1 increased detection of lymphovascular invasion in primary cutaneous melanoma.

  2. A similar pro (show LEP Proteins)gressive loss of leptin sensitivity caused by loss of MAGEL2 in children with Prader-Willi s (show LEP Proteins)yndrome could ex (show POMC Proteins)plain the delayed onset of increased appetite and weight gain in this complex disorder.

  3. We find that MAGE-A2 (show MAGEA2 Proteins) interacts with MDM2 (show MDM2 Proteins) via the N-terminal p53 (show TP53 Proteins)-binding pocket and the RING finger (show PCGF1 Proteins) domain of MDM2 (show MDM2 Proteins) that is required for homo/hetero-dimerization and for E2 ligase interaction.

  4. Truncating Mutations of MAGEL2, a Gene within the Prader-Willi Locus, Are Responsible for Severe Arthrogryposis.

  5. Consistent with increased cell death, the induced loss of MAGEA2 expression correlated with increased caspase 3 (show CASP3 Proteins)/7 activity, BCL2 (show BCL2 Proteins)/BAX (show BAX Proteins) ratio and TUNEL signal.

  6. MAGEA2 has a critical role in the development of tamoxifen-resistant breast cancer

  7. MAGEL2 is a new gene causing complex autism spectrum disorder and MAGEL2 loss of function can contribute to several aspects of the Prader-Willi syndrome phenotype.

  8. These findings provide a cellular and molecular function for MAGE-L2-TRIM27 (show RFP Proteins) in retrograde transport, including an unappreciated role of K63-linked ubiquitination and identification of an activating signal of the WASH regulatory complex.

  9. MageA2 interferes with p53 (show TP53 Proteins) acetylation at PML (show PML Proteins)-nuclear bodies (NBs (show NBN Proteins)) and with PMLIV-dependent activation of p53 (show TP53 Proteins).

  10. Report MAGEA1 (show MAGEA1 Proteins)-A6 expression in sputum suggests presence of lung cancer cells or precancerous cells.

Pig (Porcine) MAGE-Like 2 (MAGEL2) interaction partners

  1. Moreover, -712C>G and -708T>C had significant effects on MAGEL2 transcription and placental efficiency

  2. Imprinting analysis showed that NDN (show NDN Proteins) and MAGEL2 are paternally expressed in all tissues of pig where the genes were expressed as in human and mouse.

Mouse (Murine) MAGE-Like 2 (MAGEL2) interaction partners

  1. these findings suggest that a loss of Magel2 leads to the disruption of hypothalamic feeding circuits, an effect that appears to be independent of the neurodevelopmental effects of leptin (show LEP Proteins) and ghrelin (show GHRL Proteins) and likely involves a direct neurotrophic effect of Magel2.

  2. Normal leptin (show LEP Proteins) responses were found in Magel2-null mice up to 4 weeks of age, but the proportion of leptin (show LEP Proteins)-responsive POMC (show POMC Proteins) neurons was reduced in 6-week-old Magel2-null mice.

  3. Magel2 inactivation induces a deficit in social recognition and social interaction and a reduced learning ability in adult male mice.

  4. This neural defect, together with increased fat mass, blunted circadian rhythm, and growth hormone (show GH1 PLURAL_@44953@) response pathway defects that are also linked to loss of MAGEL2, could contribute to the hyperphagia and obesity that are hallmarks of this disorder.

  5. This study demonstrated that Magel2-null mice have abnormalities of hypothalamic endocrine axes that recapitulate phenotypes in Prader-Willi syndrome.

  6. Magel2-deficient mouse with 50% neonatal mortality had an altered onset of suckling activity and subsequent impaired feeding.

  7. Magel2 gene is imprinted, with preferential expression from the paternal allele in mouse and human.

  8. role of the circadian rhythm output gene Magel2 in brain structure and behavior

  9. necdin (show NDN Proteins) and MAGE-G1 (show NDNL2 Proteins) target both E2F1 (show E2F1 Proteins) and p75 (show NGFR Proteins) to regulate cell viability during brain development.

  10. Inactivation of the mouse Magel2 gene results in growth abnormalities similar to Prader-Willi syndrome

MAGE-Like 2 (MAGEL2) Protein Profile

Protein Summary

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.

Gene names and symbols associated with MAGE-Like 2 Proteins (MAGEL2)

  • MAGE-like 2 (MAGEL2)
  • MAGE-like protein 2 (LOC100343334)
  • MAGE-like 2 (Magel2)
  • melanoma antigen family A, 2 (MAGEA2)
  • melanoma antigen, family L, 2 (Magel2)
  • CT1.2 protein
  • Mage-l2 protein
  • MAGE2 protein
  • MAGEA2A protein
  • MAGEL2 protein
  • NDNL1 protein
  • nM15 protein
  • ns7 protein

Protein level used designations for MAGE-Like 2 Proteins (MAGEL2)

MAGE-like 2 , MAGE-like protein 2 , necdin-like protein 1 , protein nM15 , melanoma antigen-like gene 2 , melanoma antigen, family L, 2 , MAGE-2 antigen , cancer/testis antigen 1.2 , cancer/testis antigen family 1, member 2 , melanoma antigen 2 , melanoma-associated antigen 2 , necdin-like 1 , protein nS7

719760 Macaca mulatta
100343334 Oryctolagus cuniculus
54551 Homo sapiens
100154924 Sus scrofa
538665 Bos taurus
679875 Rattus norvegicus
4101 Homo sapiens
27385 Mus musculus
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