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MAP/microtubule Affinity-Regulating Kinase 1 Proteins (MARK1)

Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Additionally we are shipping MARK1 Antibodies (127) and MARK1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MARK1 226778 Q8VHJ5
MARK1 117016 O08678
MARK1 4139 Q9P0L2
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Top MARK1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,328.50
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details

MARK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human ,
,

More Proteins for MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) Interaction Partners

Mouse (Murine) MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) interaction partners

  1. In vitro kinase assays and metabolic-labeling experiments in living cells confirmed MARK1 as an LRRK2 (show LRRK2 Proteins) substrate. Moreover, we also showed that LRRK2 (show LRRK2 Proteins) and MARK1 are interacting in eukaryotic cells.

  2. Overexpression and silencing of MARK1 resulted in significantly shorter dendrite length in mouse neocortical neurons and modified dendritic transport speed.

Human MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) interaction partners

  1. the positioning of MARK/Par-1 (show MARK2 Proteins) at the crosstalk of regulating cytoskeletal dynamics allows its participation in neuronal polarity decisions. [review]

  2. LKB1 acts through its substrates of the microtubule affinity-regulating kinase family to regulate the localization of the polarity determinant Scribble and the activity of the core Hippo kinases

  3. In the Australian GWAS, the SNP rs7530302 near MARK1 on chromosome 1 (p=1.90 x 10(-9) achieved genomewide significance for comorbid AD/ND.

  4. analysis of variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2 (show MARK2 Proteins)

  5. MARK1 was overexpressed in a prefrontal region in the brains of patients with Autism spectrum disorders.

MARK1 Protein Profile

Protein Summary

Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3) (By similarity).

Gene names and symbols associated with MARK1

  • MAP/microtubule affinity-regulating kinase 1 (mark1)
  • MAP/microtubule affinity-regulating kinase 1 (MARK1)
  • MAP/microtubule affinity-regulating kinase 1 (Mark1)
  • AW491150 protein
  • B930025N23Rik protein
  • Emk3 protein
  • MARK protein
  • MARK1 protein
  • MGC80341 protein
  • mKIAA1477 protein
  • mPar-1c protein
  • Par-1c protein
  • Par1c protein

Protein level used designations for MARK1

MAP/microtubule affinity-regulating kinase 1 , chemokine CCL-CUc , serine/threonine-protein kinase MARK1 , serine/threonine-protein kinase MARK1-like , ELKL motif serine-threonine protein kinase 3 , ELKL motif serine/threonine-protein kinase 3 , PAR1 homolog c

GENE ID SPECIES
432201 Xenopus laevis
469683 Pan troglodytes
100003170 Danio rerio
100456064 Pongo abelii
100559635 Anolis carolinensis
226778 Mus musculus
117016 Rattus norvegicus
4139 Homo sapiens
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