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MARK2 encodes a member of the Par-1 family of serine/threonine protein kinases. Additionally we are shipping MAP/microtubule Affinity-Regulating Kinase 2 Proteins (8) and many more products for this protein.
Showing 10 out of 89 products:
Cow (Bovine) Polyclonal MARK2 Primary Antibody for EIA, WB - ABIN401318
Hurov, Watkins, Piwnica-Worms: Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity. in Current biology : CB 2004
Show all 6 references for ABIN401318
Human Monoclonal MARK2 Primary Antibody for ELISA, WB - ABIN393666
Yoshimura, Terabayashi, Miki: Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation. in Molecular and cellular biology 2010
Show all 5 references for ABIN393666
Human Polyclonal MARK2 Primary Antibody for IHC (p), WB - ABIN392538
Blume-Jensen, Hunter: Oncogenic kinase signalling. in Nature 2001
Show all 2 references for ABIN392538
Human Monoclonal MARK2 Primary Antibody for ELISA, WB - ABIN560734
Hezel, Gurumurthy, Granot, Swisa, Chu, Bailey, Dor, Bardeesy, Depinho: Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. in Molecular and cellular biology 2008
Human Polyclonal MARK2 Primary Antibody for ELISA, WB - ABIN334431
Depasquale, Thompson: Prognosis in human melanoma: PAR-1 expression is superior to other coagulation components and VEGF. in Histopathology 2008
Human Polyclonal MARK2 Primary Antibody for IF, ELISA - ABIN1533969
Taylor, Noguchi, Totoki, Toyoda, Kuroki, Dewar, Lloyd, Itoh, Takeda, Kim, She, Barlow, Bloom, Bruford, Chang, Cuomo, Eichler, FitzGerald, Jaffe, LaButti, Nicol, Park, Seaman, Sougnez, Yang, Zimmer et al.: Human chromosome 11 DNA sequence and analysis including novel gene identification. ... in Nature 2006
Human Polyclonal MARK2 Primary Antibody for EIA, IHC (p) - ABIN360425
Cantrell: Phosphoinositide 3-kinase signalling pathways. in Journal of cell science 2001
MARK2 plays a role in promoting malignant phenotypes of lung cancer.
Phosphorylation of RNF41 (show RNF41 Antibodies) by Par-1b regulates basolateral membrane targeting of laminin-111 receptors.
induces asymmetric inheritance of plasma membrane domains via LGN (show GPSM2 Antibodies)-dependent mitotic spindle orientation in proliferating hepatocytes
Perturbation of PAR1b and SHP2 (show PTPN11 Antibodies) by CagA (show S100A8 Antibodies) underlies the oncogenic potential of CagA (show S100A8 Antibodies).
The MARK2 binds to the N-terminal tail of Tau and selectively phosphorylates three major and five minor serine residues in the repeat domain and C-terminal tail.
Hepatocyte Par1b defines lumen position in concert with the position of the astral microtubule anchoring complex LGN (show GPSM2 Antibodies)-NuMA (show NUMA1 Antibodies) to yield the distinct epithelial division phenotypes.
automated image analysis of MT assembly dynamics identified MARK2 as a target regulated downstream of Rac1 that promotes oriented MT growth in the leading edge to mediate directed cell migration.
The scaffolding adaptor GAB1 (show GAB1 Antibodies) interacts with two polarity proteins, PAR1 and PAR3 (show F2RL2 Antibodies).
The results identify MARK2 as an upstream regulator of PINK1 (show PINK1 Antibodies) and DeltaN-PINK1 (show PINK1 Antibodies) and provide insights into the regulation of mitochondrial trafficking in neurons and neurodegeneration in PD.
Polarity-regulating kinase partitioning-defective 1b (PAR1b) phosphorylates guanine nucleotide exchange factor H1 (GEF-H1 (show ARHGEF2 Antibodies)) to regulate RhoA (show RHOA Antibodies)-dependent actin cytoskeletal reorganization.
a model whereby MARK2 negatively regulates insulin (show INS Antibodies) sensitivity in peripheral tissue through inhibition of KSR1 (show KSR1 Antibodies)
ROCK1 (show ROCK1 Antibodies)/PAR-1b-dependent regulation of basement membrane placement is required for the coordination of tissue polarity and the elaboration of tissue structure in the developing submandibular salivary gland.
PAR1b plays a novel role in the maintenance of mature dendritic spine morphology by regulating microtubule growth and the accumulation of p140Cap (show SRCIN1 Antibodies) in dendritic spines.
Par-1b is a regulator of glucose metabolism and adiposity in the whole animal
Interaction of MARK2 with CaMKI (show CAMK1 Antibodies) results in a novel, calcium-dependent pathway that plays an important role in neuronal differentiation.
Akt (show AKT1 Antibodies) enhances the activity of PAR1 (show F2R Antibodies) to promote tau hyperphosphorylation at S262/S356, a tau species that is not recognized by the CHIP/Hsp90 (show HSP90 Antibodies) complex
Coreduction of MARK2 and DCX (show DCX Antibodies) resulted in a partial restoration of the normal neuronal migration phenotype in vivo. The kinetic behavior of the centrosomes reflected the different molecular mechanisms activated when either protein was reduced.
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene.
ELKL motif kinase 1
, PAR1 homolog b
, Ser/Thr protein kinase PAR-1B
, serine/threonine protein kinase EMK
, serine/threonine-protein kinase MARK2
, serine/threonine kinase