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MAP/microtubule Affinity-Regulating Kinase 2 Proteins (MARK2)

MARK2 encodes a member of the Par-1 family of serine/threonine protein kinases. Additionally we are shipping MAP/microtubule Affinity-Regulating Kinase 2 Antibodies (95) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MARK2 2011 Q7KZI7
MARK2 13728 Q05512
MARK2 60328 O08679
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Top MAP/microtubule Affinity-Regulating Kinase 2 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,108.50
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MARK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) Interaction Partners

Human MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) interaction partners

  1. MARK2 plays a role in promoting malignant phenotypes of lung cancer.

  2. Phosphorylation of RNF41 (show RNF41 Proteins) by Par-1b regulates basolateral membrane targeting of laminin-111 receptors.

  3. induces asymmetric inheritance of plasma membrane domains via LGN (show GPSM2 Proteins)-dependent mitotic spindle orientation in proliferating hepatocytes

  4. Perturbation of PAR1b and SHP2 (show PTPN11 Proteins) by CagA (show S100A8 Proteins) underlies the oncogenic potential of CagA (show S100A8 Proteins).

  5. The MARK2 binds to the N-terminal tail of Tau and selectively phosphorylates three major and five minor serine residues in the repeat domain and C-terminal tail.

  6. Hepatocyte Par1b defines lumen position in concert with the position of the astral microtubule anchoring complex LGN-NuMA to yield the distinct epithelial division phenotypes.

  7. automated image analysis of MT assembly dynamics identified MARK2 as a target regulated downstream of Rac1 that promotes oriented MT growth in the leading edge to mediate directed cell migration.

  8. The scaffolding adaptor GAB1 interacts with two polarity proteins, PAR1 and PAR3 (show F2RL2 Proteins).

  9. The results identify MARK2 as an upstream regulator of PINK1 (show PINK1 Proteins) and DeltaN-PINK1 (show PINK1 Proteins) and provide insights into the regulation of mitochondrial trafficking in neurons and neurodegeneration in PD.

  10. Polarity-regulating kinase partitioning-defective 1b (PAR1b) phosphorylates guanine nucleotide exchange factor H1 (GEF-H1 (show ARHGEF2 Proteins)) to regulate RhoA (show RHOA Proteins)-dependent actin cytoskeletal reorganization.

Mouse (Murine) MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) interaction partners

  1. a model whereby MARK2 negatively regulates insulin (show INS Proteins) sensitivity in peripheral tissue through inhibition of KSR1 (show KSR1 Proteins)

  2. ROCK1 (show ROCK1 Proteins)/PAR-1b-dependent regulation of basement membrane placement is required for the coordination of tissue polarity and the elaboration of tissue structure in the developing submandibular salivary gland.

  3. PAR1b plays a novel role in the maintenance of mature dendritic spine morphology by regulating microtubule growth and the accumulation of p140Cap (show SRCIN1 Proteins) in dendritic spines.

  4. Par-1b is a regulator of glucose metabolism and adiposity in the whole animal

  5. Interaction of MARK2 with CaMKI (show CAMK1 Proteins) results in a novel, calcium-dependent pathway that plays an important role in neuronal differentiation.

  6. Akt (show AKT1 Proteins) enhances the activity of PAR1 (show F2R Proteins) to promote tau hyperphosphorylation at S262/S356, a tau species that is not recognized by the CHIP/Hsp90 (show HSP90 Proteins) complex

  7. Coreduction of MARK2 and DCX (show DCX Proteins) resulted in a partial restoration of the normal neuronal migration phenotype in vivo. The kinetic behavior of the centrosomes reflected the different molecular mechanisms activated when either protein was reduced.

MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) Protein Profile

Protein Summary

This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MARK2

  • MAP/microtubule affinity-regulating kinase 2 (MARK2)
  • MAP/microtubule affinity-regulating kinase 2 (Mark2)
  • AU024026 protein
  • Emk protein
  • EMK-1 protein
  • EMK1 protein
  • mKIAA4207 protein
  • Par-1 protein
  • Par-1b protein
  • Par1b protein

Protein level used designations for MARK2

ELKL motif kinase 1 , PAR1 homolog b , Ser/Thr protein kinase PAR-1B , serine/threonine protein kinase EMK , serine/threonine-protein kinase MARK2 , EMK-1 , EMK1 , serine/threonine kinase

GENE ID SPECIES
100049882 Equus caballus
2011 Homo sapiens
13728 Mus musculus
483769 Canis lupus familiaris
535197 Bos taurus
60328 Rattus norvegicus
100737238 Sus scrofa
100731733 Cavia porcellus
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