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MAP/microtubule Affinity-Regulating Kinase 4 Proteins (MARK4)

MARK4 encodes a member of the microtubule affinity-regulating kinase family. Additionally we are shipping MARK4 Antibodies (116) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MARK4 57787 Q96L34
MARK4 232944 Q8CIP4
Rat MARK4 MARK4 680407  
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Top MARK4 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details

MARK4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for MAP/microtubule Affinity-Regulating Kinase 4 (MARK4) Interaction Partners

Human MAP/microtubule Affinity-Regulating Kinase 4 (MARK4) interaction partners

  1. Atypical PKC (show PRRT2 Proteins) phosphorylates serine-threonine residues of MARK4.

  2. Suggest role for polypyrimidine-tract binding protein (show PTBP1 Proteins) in regulating alternative splicing of MARK4 in gliomas.

  3. MARK4 is a key component in the regulation of microtubule dynamics and has major role in cell cycle progression, particularly at the G1/S transition.

  4. Molecular dynamic simulation data predicted the three dimensional structure for the kinase domain of MARK4 and its structural properties.

  5. A strong and significant elevation of MARK4 expression and MARK4-tau interactions in AD brains correlates with the Braak stages of the disease, suggesting that the MARK4-tau interactions are of functional importance in the progression of AD.

  6. MARK4 is a critical positive regulator of early steps in ciliogenesis.

  7. MARK4 is a new negative regulator of mTORC1

  8. The balance between the MARK4 isoforms is carefully guarded during neural differentiation but may be subverted in gliomagenesis.

  9. Even though an association of the polymorphisms rs2850328 and rs2395 and breast cancer was not detected in our case-control study population, other variants within the PPP3CA (show PPP3CA Proteins) and MARK4 genes may still be associated with breast cancer.

  10. demonstrated that the endogenous MARK4L colocalizes with centrosomes at all mitotic stages and resides in centrosome-enriched fractions.

Mouse (Murine) MAP/microtubule Affinity-Regulating Kinase 4 (MARK4) interaction partners

  1. MARK4 is a critical positive regulator of early steps in ciliogenesis.

  2. data indicate a key role of MARK4 in energy metabolism, implicating the kinase as a novel drug target for the treatment of obesity and type 2 diabetes.

  3. The balance between the MARK4 isoforms is carefully guarded during neural differentiation but may be subverted in gliomagenesis.

  4. MARK4 is a functional protein kinase (show CDK7 Proteins) which specifically phosphorylates a cognate peptide substrate for the AMP (show TMPRSS5 Proteins)-kinase family. On overexpression in heterologous cells functional wild-type protein, but not its kinase-dead mutant, decreased cell viability

MARK4 Protein Profile

Protein Summary

This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with MARK4

  • MAP/microtubule affinity-regulating kinase 4 (MARK4)
  • MAP/microtubule affinity-regulating kinase 4 (Mark4)
  • 2410090P21Rik protein
  • C79806 protein
  • MARK4 protein
  • MARK4L protein
  • MARK4S protein
  • Markl1 protein
  • MARKL1L protein
  • PAR-1D protein

Protein level used designations for MARK4

MAP/microtubule affinity-regulating kinase 4 , MAP/microtubule affinity-regulating kinase like 1 , MARK4 serine/threonine protein kinase , MAP/microtubule affinity-regulating kinase 4L

GENE ID SPECIES
100070770 Equus caballus
456123 Pan troglodytes
57787 Homo sapiens
232944 Mus musculus
680407 Rattus norvegicus
484449 Canis lupus familiaris
525675 Bos taurus
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