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MXD1 encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. Additionally we are shipping MXD1 Antibodies (44) and MXD1 Kits (21) and many more products for this protein.
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down regulation of miR (show MLXIP Proteins)-202 increased the expression of its target Mxd1, followed by Mxd1 recruitment to the Sin3A (show SIN3A Proteins) repressor complex and through its dimerization with Max, and increased repression of Myc (show MYC Proteins)-Max target proteins.
miR-17-92 cluster members miR (show MLXIP Proteins)-19a/b facilitated gastric cancer cell migration, invasion and metastasis through targeting the antagonist of c-Myc (show MYC Proteins) -- MXD1.
This study suggests that genetic variants of MXD1 may modulate the effect of smoking on carotid plaque burden.
Mad1 gene transfer inhibits the proliferation of human melanoma cells
HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations
MAD1 and Proto-Oncogene (show RAB1A Proteins) Proteins c-myc (show MYC Proteins) reciprocally regulate ribosomal DNA transcription, providing a mechanism for coordination of ribosome biogenesis and cell growth
c-myc (show MYC Proteins) and mad1 can regulate the hTERT transcript in a different manner in hTERT positive cells, but not in normal cells
Mad1, Mxi1 and Rox genes were expressed and displayed mutations in haematological malignancies.
This study provides a direct link between the growth factor signaling pathways regulated by PI3 kinase (show PIK3CA Proteins)/Akt (show AKT1 Proteins) and MAP kinases with Myc (show MYC Proteins)-mediated transcription.
TGF-beta (show TGFB1 Proteins) can override Myc (show MYC Proteins) activity despite a stabilizing cancer mutation and induce senescence in myeloid tumor cells, at least in part by induction of Mad1
1,25D and the VDR (show CYP27B1 Proteins) regulate the c-MYC (show MYC Proteins)/MXD1 network to suppress c-MYC (show MYC Proteins) function, providing a molecular basis for cancer preventive actions of vitamin D.
Phe-7 is the critical determinant and provides the molecular specificity for the association between Sin3 and Mad in regulating cell growth and differentiation.
Mad1 is a transcriptional repressor of Bcl-6 (show BCL6 Proteins).
This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
MAX dimerization protein 1
, MAD protein
, max dimerization protein 1
, max dimerizer 1
, MAX-binding protein
, antagonizer of myc transcriptional activity