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MAX Interactor 1 Proteins (MXI1)

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. Additionally we are shipping MXI1 Antibodies (48) and MXI1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MXI1 17859 P50540
MXI1 25701  
MXI1 4601 P50539
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Top MXI1 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,572.17
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,619.83
Details

MXI1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human ,
,

More Proteins for MAX Interactor 1 (MXI1) Interaction Partners

Mouse (Murine) MAX Interactor 1 (MXI1) interaction partners

  1. The mesangial cell apoptosis observed in this mesangial proliferative glomerulonephritis model was related to CXCL10 (show CXCL10 Proteins) expression induced by Mxi1 inactivation.

  2. Mxi1 regulates Ift20 (show IFT20 Proteins) promoter activity via Ets-1 (show ETS1 Proteins) binding to the Ift20 (show IFT20 Proteins) promoter. These results indicate that inactivating Mxi1 induces ciliary defects in polycystic kidney.

  3. The results support the suggestion that over-expression of Mxi1 can suppress renal epithelial tubulogenesis.

  4. The results support the suggestion that inactivation of Mxi1 has a positive effect on cell proliferation by down-regulating IGFBP-3 (show IGFBP3 Proteins).

  5. down-regulation of miR (show MLXIP Proteins)-191 is essential for erythroid chromatin condensation and enucleation by allowing up-regulation of Riok3 (show RIOK3 Proteins) and Mxi1

  6. Mxi1-SRalpha (show SRPR Proteins) is an isoform with enhanced transcriptional repression potential

  7. Apolipoprotein A1 (show APOA1 Proteins) which is a major component of the high-density lipoprotein complex and has anti-inflammation effects, was significantly decreased in the Mxi1-deficient mouse.

Human MAX Interactor 1 (MXI1) interaction partners

  1. MYC (show MYC Proteins)-HEG (show HEG1 Proteins) and MXI1-LEG levels are associated with poor prognosis in patients with breast cancer, suggesting that they may be useful molecular markers in breast cancer prognosis prediction.

  2. MicroRNA-155 promotes glioma cell proliferation via the regulation of MXI1.

  3. MXI1-0 appears to be a downstream target of MYCN (show MYCN Proteins)-dependent signaling pathways and may contribute to N-Myc (show MYCN Proteins)-dependent cell growth and proliferation.

  4. These findings reveal, for the first time, the novel functions of cooperation of miR243p and miR27a3p from two clusters in promoting cell proliferation through MXI1.

  5. Mxi1 can act as a tumour suppressor in human glioblastomas through a molecular mechanism involving the transcriptional down-regulation of cyclin B1 (show CCNB1 Proteins) gene expression.

  6. These findings support MXI1 as a putative tumor suppressor gene involved in conventional melanoma progression.

  7. Mxi1-SRalpha (show SRPR Proteins) is an isoform with enhanced transcriptional repression potential

  8. Data show that PTEN and MXI1 were two candidate tumor suppressor genes on 10q23 and 10q24-q25 and may be potentially involved in the initiation and progression of prostate carcinoma.

  9. Mxi-D may play an important role in the c-Myc (show MYC Proteins) family protein network acting as a dominant negative isoform of Mxi-F stimulated by c-Myc (show MYC Proteins)

  10. p300 (show EP300 Proteins) can acetylate DNA-bound Myc:Max complexes and that acetylated Myc:Max heterodimers efficiently interact with Miz-1 (show ZBTB17 Proteins)

MXI1 Protein Profile

Protein Summary

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.

Gene names and symbols associated with MAX Interactor 1 Proteins (MXI1)

  • max interactor 1 (mxi1)
  • MAX interactor 1 (MXI1)
  • MAX interactor 1 (LOC100230389)
  • max interacting protein (mxi1)
  • Max interacting protein 1 (Mxi1)
  • MAX interactor 1 (Mxi1)
  • MAX interactor 1, dimerization protein (MXI1)
  • MAX interactor 1, dimerization protein (mxi1)
  • bHLHc11 protein
  • ENSMUSG00000067085 protein
  • etID309773.22 protein
  • fb16b12 protein
  • fb55f03 protein
  • Gm10197 protein
  • MAD2 protein
  • MGC89544 protein
  • MXD2 protein
  • MXI protein
  • MXI-WR protein
  • MXI1 protein
  • wu:fb16b12 protein
  • wu:fb55f03 protein
  • wu:fd06a08 protein
  • wu:fz74f10 protein
  • xmxi1 protein

Protein level used designations for MAX Interactor 1 Proteins (MXI1)

max interactor 1 , MAX interactor 1 , adducin 3 (gamma) , max-interacting protein 1 , MAX interacting protein 1 , Max interacting protein 1 , MAX dimerization protein 2 , Max-related transcription factor , class C basic helix-loop-helix protein 11

GENE ID SPECIES
493491 Xenopus (Silurana) tropicalis
694630 Macaca mulatta
737181 Pan troglodytes
100154269 Sus scrofa
100230389 Taeniopygia guttata
30485 Danio rerio
17859 Mus musculus
423888 Gallus gallus
609946 Canis lupus familiaris
614509 Bos taurus
25701 Rattus norvegicus
4601 Homo sapiens
734207 Xenopus laevis
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