MDS1 and EVI1 Complex Locus Proteins (MECOM)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping MDS1 and EVI1 Complex Locus Antibodies (118) and MDS1 and EVI1 Complex Locus Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
Rat MECOM MECOM 294924  
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Top MDS1 and EVI1 Complex Locus Proteins at antibodies-online.com

Showing 4 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 2 to 3 Days
$388.93
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MECOM Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for MDS1 and EVI1 Complex Locus (MECOM) Interaction Partners

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (show NOTCH1 Proteins) signaling

  2. Prdm3 and prdm16 (show PRDM16 Proteins) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. these findings have identified a novel function for Runx1 (show RUNX1 Proteins) in sustaining normal mammary epithelial morphology and preventing epithelial-mesenchymal transition

  2. Leukaemogenesis by AML1 (show RUNX1 Proteins)-ETO (show RUNX1T1 Proteins) requires enhanced C/D box snoRNA/RNP (show RNPC3 Proteins) formation.

  3. The expression of EVI1 and SOX9 (show SOX9 Proteins) is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR (show FRAP1 Proteins) inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR (show FRAP1 Proteins) targeting failure

  4. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (show F2 Proteins)-activatable receptor PAR-1 (protease-activated receptor-1 (show F2R Proteins)), in Runx1 (show RUNX1 Proteins)/Cbfb (show CBFB Proteins)-deleted MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) cells. Similar to the effect of Runx1 (show RUNX1 Proteins)/Cbfb (show CBFB Proteins) deletion, PAR-1 (show MARK2 Proteins) overexpression induced CDKN1A/p21 (show CDKN1A Proteins) expression and attenuated proliferation in MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) cells

  5. EVI1 contributes to PCa (show FLVCR1 Proteins) progression by regulating different oncogenic functions. EVI1 regulates the PCa (show FLVCR1 Proteins) stem cell compartment responsible for disease initiation and also development of CRPC.

  6. oncogenic potential for EVI1 in modulating genomic stability

  7. LRG1 (show LRG1 Proteins) plays a crucial role in the proliferation and apoptosis of colorectal cancer (CRC (show CALR Proteins)) by regulating RUNX1 (show RUNX1 Proteins) expression.

  8. RUNX1 (show RUNX1 Proteins) RNA and protein are upregulated in proliferative diabetic retinopathy and in response to high glucose in vitro. Immunohistochemical staining for RUNX1 (show RUNX1 Proteins) showed reactivity in vessels of patient-derived fibrovascular membranes, suggesting that RUNX1 (show RUNX1 Proteins) upregulation is a hallmark of aberrant retinal angiogenesis.

  9. RUNX1 (show RUNX1 Proteins) overexpression induced partial DNA demethylation at SPI1 (show SPI1 Proteins) proximal promoter.

  10. mutations in the SRSF2 (show SRSF2 Proteins)/ASXL1 (show ASXL1 Proteins)/RUNX1 (show RUNX1 Proteins) gene panel identified as significant prognostic markers in systemic mastocytosis

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  2. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (show CEBPA Proteins) from EVI1-induced suppression.

  3. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (show CSF2 Proteins), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (show CSF2 Proteins) levels.

  4. Survivin (show BIRC5 Proteins) partially regulates HSC (show FUT1 Proteins) function by modulating the Evi-1 transcription factor and its downstream targets

  5. Thrombopoietin (show THPO Proteins)/MPL (show MPL Proteins) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  6. Prdm16 (show PRDM16 Proteins) and Prdm3 control postnatal BAT (show BAAT Proteins) identity and function.

  7. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  8. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (show MLL Proteins)) fusion protein (MFP) leukemia

  9. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (show CEBPB Proteins), liver inhibitory protein (LIP), induced acute myeloid leukemia (show BCL11A Proteins) with short latencies in a mouse bone marow transplantation model.

  10. Transient Evi1 transfection inhibited TGF-beta (show TGFB1 Proteins)-induced transcriptional activity and reversed the growth inhibitory effect of TGF-beta (show TGFB1 Proteins) in MC-26 (show Glycam1 Proteins) mouse colon cancer cells.

MDS1 and EVI1 Complex Locus (MECOM) Protein Profile

Protein Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (mecom)
  • MDS1 and EVI1 complex locus (MECOM)
  • MDS1 and EVI1 complex locus (LOC100343228)
  • MDS1 and EVI1 complex locus (Mecom)
  • runt-related transcription factor 1 (RUNX1)
  • AML1 protein
  • AML1-EVI-1 protein
  • AMLCR1 protein
  • CBFA2 protein
  • D630039M04Rik protein
  • EVI-1 protein
  • Evi1 protein
  • im:7140716 protein
  • Jbo protein
  • Mds protein
  • Mds1 protein
  • Mds1-Evi1 protein
  • PEBP2aB protein
  • Prdm3 protein
  • Znfpr1b1 protein

Protein level used designations for MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

GENE ID SPECIES
497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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