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MDS1 and EVI1 Complex Locus Proteins (MECOM)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping MDS1 and EVI1 Complex Locus Antibodies (118) and MDS1 and EVI1 Complex Locus Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
Rat MECOM MECOM 294924  
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Top MDS1 and EVI1 Complex Locus Proteins at antibodies-online.com

Showing 4 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
$11,073.30
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
$11,073.30
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 3 to 4 Days
$388.93
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MECOM Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for MDS1 and EVI1 Complex Locus (MECOM) Interaction Partners

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (show NOTCH1 Proteins) signaling

  2. Prdm3 and prdm16 (show PRDM16 Proteins) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. A feedback circuitry involving miR (show MLXIP Proteins)-9-1 and RUNX1 (show RUNX1 Proteins)-RUNX1T1 (show RUNX1T1 Proteins).

  2. The requirement for Runx1 (show RUNX1 Proteins) in the normal hematopoietic development and its dysregulation through chromosomal translocations and loss-of-function mutations as found in acute myeloid leukemias highlight the importance of this transcription factor in the healthy blood system.

  3. RUNX1 (show RUNX1 Proteins) is one of the most frequently mutated genes in a variety of hematological malignancies. Germ line mutations in RUNX1 (show RUNX1 Proteins) cause familial platelet disorder with associated myeloid malignancies.

  4. In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2 (show NR4A2 Proteins))early growth response (EGR)2 (show EGR2 Proteins) and NR4A2EGR3. Therefore, RUNX1 (show RUNX1 Proteins), NR4A2 (show NR4A2 Proteins), EGR2 (show EGR2 Proteins), EGR3 (show EGR3 Proteins) and ID4 (show ID4 Proteins) may be key genes associated with the pathogenesis of DS.

  5. Study shows that AML1 gene overexpression characterizes a broader range of leukemic subtypes than previously thought, including various maturation stages of B-cell acute lymphoblastic leukemia and cytogenetic types additional to those involving the AML1 gene.

  6. MECOM gene harbors both somatic frameshift mutations.

  7. the effects of various aberrations in ETV6 (show ETV6 Proteins) and RUNX1 (show RUNX1 Proteins) gene copy number on disease prognosis were evaluated in 21 pediatric patients diagnosed with B-cell ALL with/without t(12;21).

  8. The RUNX1 (show RUNX1 Proteins) fusion transcript encodes a truncated protein containing the Runt (show RUNX1 Proteins) homology domain responsible for both heterodimerization with CBFB (show CBFB Proteins) and DNA binding, but lacking the proline-, serine-, and threonine-rich (PST (show SULT1A1 Proteins)) region which is the transcription activation domain at the C terminal end

  9. novel RUNX1 (show RUNX1 Proteins) isoforms contribute in controlling CD56 (show NCAM1 Proteins) expression in acute myeloid leukemia (show BCL11A Proteins) cells.

  10. this paper shows that RUNX1 (show RUNX1 Proteins) is associated with the pathogenesis of immune thrombocytopenia possibly through regulation of Th17 cell differentiation

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (show CEBPA Proteins) from EVI1-induced suppression.

  2. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (show CSF2 Proteins), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (show CSF2 Proteins) levels.

  3. Survivin (show BIRC5 Proteins) partially regulates HSC (show FUT1 Proteins) function by modulating the Evi-1 transcription factor and its downstream targets

  4. Thrombopoietin (show THPO Proteins)/MPL (show MPL Proteins) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  5. Prdm16 (show PRDM16 Proteins) and Prdm3 control postnatal BAT (show BAAT Proteins) identity and function.

  6. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  7. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (show MLL Proteins)) fusion protein (MFP) leukemia

  8. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (show CEBPB Proteins), liver inhibitory protein (LIP), induced acute myeloid leukemia (show BCL11A Proteins) with short latencies in a mouse bone marow transplantation model.

  9. Transient Evi1 transfection inhibited TGF-beta (show TGFB1 Proteins)-induced transcriptional activity and reversed the growth inhibitory effect of TGF-beta (show TGFB1 Proteins) in MC-26 (show Glycam1 Proteins) mouse colon cancer cells.

  10. Evi1 is a key regulator of adipogenic competency

MDS1 and EVI1 Complex Locus (MECOM) Protein Profile

Protein Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (mecom)
  • MDS1 and EVI1 complex locus (MECOM)
  • MDS1 and EVI1 complex locus (LOC100343228)
  • MDS1 and EVI1 complex locus (Mecom)
  • runt-related transcription factor 1 (RUNX1)
  • AML1 protein
  • AML1-EVI-1 protein
  • AMLCR1 protein
  • CBFA2 protein
  • D630039M04Rik protein
  • EVI-1 protein
  • Evi1 protein
  • im:7140716 protein
  • Jbo protein
  • Mds protein
  • Mds1 protein
  • Mds1-Evi1 protein
  • PEBP2aB protein
  • Prdm3 protein
  • Znfpr1b1 protein

Protein level used designations for MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

GENE ID SPECIES
497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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