MHC Class I Polypeptide-Related Sequence B Proteins (MICB)

MICB encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Additionally we are shipping MICB Antibodies (71) and MICB Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MICB 4277 Q29980
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Top MICB Proteins at

Showing 7 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 13 to 16 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 8 to 11 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 4 to 6 Days

MICB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,

Top referenced MICB Proteins

  1. Human MICB Protein expressed in Human Cells - ABIN2003355 : Bauer, Groh, Wu, Steinle, Phillips, Lanier, Spies: Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. in Science (New York, N.Y.) 1999 (PubMed)
    Show all 3 references for 2003355

More Proteins for MHC Class I Polypeptide-Related Sequence B (MICB) Interaction Partners

Human MHC Class I Polypeptide-Related Sequence B (MICB) interaction partners

  1. This demonstrates for the first time that MICA (show MICA Proteins)/B is more broadly expressed in normal tissue and that expression is mainly intracellular with only a small fraction appearing on the cell surface of some epithelia and tumour cells.

  2. this study shows that vigilin (HDLBP (show HDLBP Proteins)) binds and negatively regulates MICB expression through its 5'UTR, and that vigilin (show HDLBP Proteins) downregulation in target cells leads to NK cell activation against said target cells

  3. we have found that the allele G of rs3828903 was significantly associated with risk susceptibility to SLE in the current population. These data together with the functional annotations of rs3828903 convert MICB into a main candidate for being an additional MHC gene associated with SLE susceptibility.

  4. this study presents the impact of a single nucleotide transition at SNPs associated with DSS (show NR0B1 Proteins) on differential protein binding patterns with PLCE1 (show PLCE1 Proteins) and MICB genes and on protein structure modification and their possible role in the pathogenesis of dengue shock syndrome

  5. there is no obvious correlation between the MMP9 (show MMP9 Proteins) -1562 C/T SNP and the concentrations of circulating MICA (show MICA Proteins)/B in the breast cancer patients.

  6. Findings shown here are important from an anthropologic perspective and will inform future studies of the potential role of MICA (show MICA Proteins) and MICB genes in allogeneic organ transplantation and HLA-linked disease association in populations of related ancestry.

  7. IMP3 (show IGF2BP3 Proteins) directly interacts with ULBP2 (show ULBP2 Proteins) mRNA, leading to ULBP2 (show ULBP2 Proteins) transcript destabilization and reduced ULBP2 (show ULBP2 Proteins) surface expression and indirectly downregulates MICB with a mechanism functionally distinct from that of ULBP2 (show ULBP2 Proteins).

  8. Reversal of epigenetic silencing of MICA (show MICA Proteins) and MICB improves immune recognition and killing of Merkel cell carcinoma cells.

  9. We have now found a total of 15 individual MICB promoter sequences, varying by combination of 18 polymorphic positions within the MICB minimal promoter sequence.

  10. Our results suggest that locally sustained expression of MICA (show MICA Proteins) and MICB in the tumor may contribute to the malignant progression of Gastric cancer(GC) and that expression of these ligands predicts an unfavorable prognosis in GC patients presenting large tumors.

MICB Protein Profile

Protein Summary

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules\; however, it does not associate with beta-2-microglobulin or bind peptides.

Gene names and symbols associated with MICB

  • MHC class I polypeptide-related sequence B (MICB)
  • MHC class I-related protein-like (LOC512825)
  • PERB11.2 protein

Protein level used designations for MICB

MHC class I chain-related protein B , MHC class I mic-B antigen , MHC class I-like molecule PERB11.2-IMX , MIC-B , stress inducible class I homolog

4277 Homo sapiens
512825 Bos taurus
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