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Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis (By similarity). Additionally we are shipping MIS18 Kinetochore Protein Homolog A (S. Pombe) Antibodies (22) and many more products for this protein.
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the Mis18 complex contains dual CENP-C recognition motifs that are combinatorially required to generate robust centromeric localization that leads to CENP-A (show CENPA Proteins) deposition
Mis18alpha is important for epidermal cell proliferation and stratification, because it is required for the deposition of CENP-A (show CENPA Proteins) at the centromeric nucleosomes.
Stable binding of Mis18alpha-Mis18beta (show OIP5 Proteins) heterotetramer to centromeres in telophase licenses them for CENP-A (show CENPA Proteins) deposition.
it is suggested that pp5644 physically bind to FASP1
Three human proteins essential for centromere/kinetochore structure and function, hMis18alpha, hMis18beta (show OIP5 Proteins), and M18BP1 (show MIS18BP1 Proteins), the complex of which is accumulated specifically at the telophase-G1 centromere, are identified.[Mis18alpha, Mis18beta (show OIP5 Proteins), M18BP1 (show MIS18BP1 Proteins)]
Mis18alpha interacts with DNMT3A (show DNMT3A Proteins)/3B, and this interaction is critical for maintaining DNA methylation (show HELLS Proteins) and hence regulating epigenetic states of centromeric chromatin.
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis (By similarity).
FAPP1-associated protein 1
, protein Mis18-alpha