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anti-MKL/myocardin-Like 2 (MKL2) Antibodies

Acts as a transcriptional coactivator of serum response factor (SRF). Additionally we are shipping MKL2 Proteins (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MKL2 100362518  
MKL2 57496 Q9ULH7
MKL2 239719 P59759
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Top anti-MKL2 Antibodies at antibodies-online.com

Showing 10 out of 28 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of MKL2 Antibody (N-term) in mouse bladder tissue lysates (35ug/lane). This demonstrates the MKL2 antibody detected the MKL2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Mouse Rabbit Un-conjugated WB MKL2 Antibody (N-term) (ABIN656903) western blot analysis in mouse bladder tissue lysates (35 µg/lane). This demonstrates the MKL2 antibody detected the MKL2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of MKL2 expression in HEK293T (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Mouse Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Mouse Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$375.83
Details
Mouse Rabbit HRP ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Mouse Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 11 to 16 Days
$532.71
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$581.17
Details

MKL2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Human , ,


Mouse (Murine)


, , , , ,

Top referenced anti-MKL2 Antibodies

  1. Human Polyclonal MKL2 Primary Antibody for EIA, WB - ABIN953457 : Huang, Sumegi, Dal Cin, Reith, Yasuda, Nelson, Muirhead, Bridge: C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. in Genes, chromosomes & cancer 2010 (PubMed)
    Show all 5 references for ABIN953457

More Antibodies against MKL2 Interaction Partners

Human MKL/myocardin-Like 2 (MKL2) interaction partners

  1. Study showed that MRTF-A (show MKL1 Antibodies) and MRTF-B were upregulated in pancreatic cancer tissues supporting the hypothesis that both of them are oncogenes in pancreatic cancer.

  2. While disruption of the MKL2:SRF axis has been associated with severe microcephaly and disordered brain development in multiple model systems, the role of this transcription factor complex has not been previously demonstrated in human brain development.

  3. There were multiple independent HIV integrations in several genes, including MKL2 and BACH2 (show BACH2 Antibodies); many of these integrations were in clonally expanded cells.

  4. MKL1 (show MKL1 Antibodies)/2 depletion resulted in Ras activation, elevated p16 (show CDKN2A Antibodies) expression and hypophosphorylation of the retinoblastoma (Rb) protein in DLC1 (show DYNLL1 Antibodies)-deficient hepatocellular carcinoma cells.

  5. Based on a recurrent translocation t(11;16)(q13;p13), the C11orf95-MKL2 fusion gene has been found in eight further cases of chondroid lipomas.

  6. study provides evidence that MKL1 (show MKL1 Antibodies)/2 mediates cancerous transformation in DLC1 (show DYNLL1 Antibodies)-deficient hepatocellular and mammary carcinoma cells

  7. C11orf95-MKL2 is the resulting fusion oncogene (show RAB1A Antibodies) of t(11;16)(q13;p13) in chondroid lipoma.

  8. dominant negative MKL2 blocked differentiation-induced expression of SRF target genes skeletal alpha-actin and alpha-myosin heavy chain and blocked differentiation of the myoblasts to myotubes in vitro.

  9. BMP signaling modulates VSMC phenotype via cross-talk with the RhoA/MRTFs pathway, and may contribute to the development of the pathological characteristics observed in patients with PAH and other obliterative vascular diseases.

  10. Myocardin (show MYOCD Antibodies)-related transcription factors are critical mediators of transforming growth factor beta (TGF-beta) 1-induced epithelial-mesenchymal transition.[

Mouse (Murine) MKL/myocardin-Like 2 (MKL2) interaction partners

  1. MRTF-A (show MKL1 Antibodies)/B depletion results in an increase in the cell surface expression of ICAM-1 (show ICAM1 Antibodies) and interactions between HAoECs and leukocytes

  2. Either MRTF-A (show MKL1 Antibodies) or MRTF-B is dispensable for cardiac development, whereas deletion of both causes a spectrum of abnormalities ranging from reduced cardiac contractility and adult onset heart failure to neonatal lethality accompanied by sarcomere disarray.

  3. These results identify SRF and its MRTF cofactors as major transcriptional regulators of endothelial cell junctional stability, guaranteeing physiological functions of the cerebral microvasculature.

  4. Suggest role for nuclear RhoA (show RHOA Antibodies) signaling in MRTF-dependent gene expression in smooth muscle cells.

  5. Myocardin (show MYOCD Antibodies)-related transcription factor (MRTF)-A (show MKL1 Antibodies) and MRTF-B (MKL1 (show MKL1 Antibodies) and MKL2, respectively) are enriched in the perinuclear space of epicardial cells during development.

  6. MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages.

  7. Smad2 (show SMAD2 Antibodies) interaction with MRTFB seems to be a novel and important mechanism underlying neural crest cell differentiation to vascular smooth muscle cells.

  8. MRTF-B knockdown leads to increase in S and G2/M populations and downregulation of cyclin (show PCNA Antibodies)-CDK (show CDK4 Antibodies) inhibitors p27Kip1 (show CDKN1B Antibodies), p18Ink4c (show CDKN2C Antibodies) and 19Ink4d as well as upregulation of p21Waf1 and cyclin D1 (show CCND1 Antibodies).

  9. Data suggest that MKL1 (show MKL1 Antibodies) and MKL2 are expressed in megakaryocytes and platelets; megakaryocytes lacking expression of MKL1 (show MKL1 Antibodies) and/or MKL2 have both defective megakaryocytopoiesis and thrombopoiesis.

  10. MKL2 regulates a conserved TGF-beta (show TGFB1 Antibodies) signaling pathway that is required for angiogenesis and ultimately embryonic survival.

MKL2 Antigen Profile

Protein Summary

Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation.

Gene names and symbols associated with MKL2

  • MKL/myocardin-like 2 (mkl2) antibody
  • MKL/myocardin-like 2 (MKL2) antibody
  • MKL/myocardin-like 2 (LOC100362518) antibody
  • MKL/myocardin-like 2 (Mkl2) antibody
  • ENSMUSG00000075401 antibody
  • Gt4-1 antibody
  • MGC145857 antibody
  • mKIAA1243 antibody
  • MRTF-B antibody
  • mrtf-b-A antibody
  • mrtfb antibody
  • NPD001 antibody

Protein level used designations for MKL2

MKL/myocardin-like 2 , megakaryoblastic leukemia 2 protein , MKL/myocardin-like protein 2 , megakaryoblastic leukemia 2 , myocardin-related transcription factor B , gene trap insertion site 4-1 , MRTF-B , xMRTF-B

GENE ID SPECIES
780107 Xenopus (Silurana) tropicalis
100050736 Equus caballus
100073360 Ornithorhynchus anatinus
100350900 Oryctolagus cuniculus
100362518 Rattus norvegicus
57496 Homo sapiens
239719 Mus musculus
378496 Xenopus laevis
Selected quality suppliers for anti-MKL2 (MKL2) Antibodies
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