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MKL/myocardin-Like 2 Proteins (MKL2)

Acts as a transcriptional coactivator of serum response factor (SRF). Additionally we are shipping MKL2 Antibodies (25) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat MKL2 MKL2 100362518  
MKL2 57496 Q9ULH7
MKL2 239719 P59759
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Top MKL2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MKL2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for MKL/myocardin-Like 2 (MKL2) Interaction Partners

Human MKL/myocardin-Like 2 (MKL2) interaction partners

  1. Study showed that MRTF-A and MRTF-B were upregulated in pancreatic cancer tissues supporting the hypothesis that both of them are oncogenes in pancreatic cancer.

  2. While disruption of the MKL2:SRF axis has been associated with severe microcephaly and disordered brain development in multiple model systems, the role of this transcription factor complex has not been previously demonstrated in human brain development.

  3. There were multiple independent HIV integrations in several genes, including MKL2 and BACH2 (show BACH2 Proteins); many of these integrations were in clonally expanded cells.

  4. MKL1/2 depletion resulted in Ras activation, elevated p16 expression and hypophosphorylation of the retinoblastoma (Rb) protein in DLC1-deficient hepatocellular carcinoma cells.

  5. Based on a recurrent translocation t(11;16)(q13;p13), the C11orf95-MKL2 fusion gene has been found in eight further cases of chondroid lipomas.

  6. study provides evidence that MKL1/2 mediates cancerous transformation in DLC1-deficient hepatocellular and mammary carcinoma cells

  7. C11orf95-MKL2 is the resulting fusion oncogene (show RAB1A Proteins) of t(11;16)(q13;p13) in chondroid lipoma.

  8. dominant negative MKL2 blocked differentiation-induced expression of SRF target genes skeletal alpha-actin and alpha-myosin heavy chain and blocked differentiation of the myoblasts to myotubes in vitro.

  9. BMP signaling modulates VSMC phenotype via cross-talk with the RhoA/MRTFs pathway, and may contribute to the development of the pathological characteristics observed in patients with PAH and other obliterative vascular diseases.

  10. Myocardin-related transcription factors are critical mediators of transforming growth factor beta (TGF-beta) 1-induced epithelial-mesenchymal transition.[

Mouse (Murine) MKL/myocardin-Like 2 (MKL2) interaction partners

  1. MRTF-A/B depletion results in an increase in the cell surface expression of ICAM-1 (show ICAM1 Proteins) and interactions between HAoECs and leukocytes

  2. Either MRTF-A or MRTF-B is dispensable for cardiac development, whereas deletion of both causes a spectrum of abnormalities ranging from reduced cardiac contractility and adult onset heart failure to neonatal lethality accompanied by sarcomere disarray.

  3. These results identify SRF and its MRTF cofactors as major transcriptional regulators of endothelial cell junctional stability, guaranteeing physiological functions of the cerebral microvasculature.

  4. Suggest role for nuclear RhoA (show RHOA Proteins) signaling in MRTF-dependent gene expression in smooth muscle cells.

  5. Myocardin-related transcription factor (MRTF)-A and MRTF-B (MKL1 and MKL2, respectively) are enriched in the perinuclear space of epicardial cells during development.

  6. MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages.

  7. Smad2 (show SMAD2 Proteins) interaction with MRTFB seems to be a novel and important mechanism underlying neural crest cell differentiation to vascular smooth muscle cells.

  8. MRTF-B knockdown leads to increase in S and G2/M populations and downregulation of cyclin (show PCNA Proteins)-CDK (show CDK4 Proteins) inhibitors p27Kip1 (show CDKN1B Proteins), p18Ink4c (show CDKN2C Proteins) and 19Ink4d as well as upregulation of p21Waf1 and cyclin D1 (show CCND1 Proteins).

  9. Data suggest that MKL1 and MKL2 are expressed in megakaryocytes and platelets; megakaryocytes lacking expression of MKL1 and/or MKL2 have both defective megakaryocytopoiesis and thrombopoiesis.

  10. MKL2 regulates a conserved TGF-beta (show TGFB1 Proteins) signaling pathway that is required for angiogenesis and ultimately embryonic survival.

MKL2 Protein Profile

Protein Summary

Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation.

Gene names and symbols associated with MKL/myocardin-Like 2 Proteins (MKL2)

  • MKL/myocardin-like 2 (mkl2)
  • MKL/myocardin-like 2 (MKL2)
  • MKL/myocardin-like 2 (LOC100362518)
  • MKL/myocardin-like 2 (Mkl2)
  • ENSMUSG00000075401 protein
  • Gt4-1 protein
  • MGC145857 protein
  • mKIAA1243 protein
  • MRTF-B protein
  • mrtf-b-A protein
  • mrtfb protein
  • NPD001 protein

Protein level used designations for MKL/myocardin-Like 2 Proteins (MKL2)

MKL/myocardin-like 2 , megakaryoblastic leukemia 2 protein , MKL/myocardin-like protein 2 , megakaryoblastic leukemia 2 , myocardin-related transcription factor B , gene trap insertion site 4-1 , MRTF-B , xMRTF-B

GENE ID SPECIES
780107 Xenopus (Silurana) tropicalis
100050736 Equus caballus
100073360 Ornithorhynchus anatinus
100350900 Oryctolagus cuniculus
100362518 Rattus norvegicus
57496 Homo sapiens
239719 Mus musculus
378496 Xenopus laevis
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