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MONDOA forms heterodimers with MLX (MIM 602976) that can bind to and activate transcription from CACGTG E boxes (Billin et al., 2000 [PubMed 11073985]).[supplied by OMIM, Mar 2008].. Additionally we are shipping MLX Interacting Protein Antibodies (31) and MLX Interacting Protein Proteins (7) and many more products for this protein.
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MondoA-directed programs have a key role in the coordinated control of myocyte lipid balance and insulin (show INS ELISA Kits) signaling
Evaluation of the conservation of ChREBP (show MLXIPL ELISA Kits) and MondoA sequences demonstrate that MondoA is better conserved and potentially mediates more ancient function in glucose metabolism.
These results suggest that C771G polymorphism of MLXIPL (show MLXIPL ELISA Kits) gene is associated with coronary stenosis and its severity.
Knockdown of MondoA, or its dimerization partner Mlx (show MLX ELISA Kits), blocks Myc (show MYC ELISA Kits)-induced reprogramming of multiple metabolic pathways, resulting in apoptosis
regulatory relationship between mTOR (show FRAP1 ELISA Kits) and the MondoA-TXNIP (show TXNIP ELISA Kits) axis that we propose contributes to glucose homeostasis
Suppression of Txnip (show TXNIP ELISA Kits) by lipopolysaccharide is accompanied by a decrease of the glucose sensing transcription factor MondoA in the nuclei.
An important contribution of MondoA to leukemia aggressiveness, which makes MondoA a potential candidate for targeted treatment of acute lymphoblastic leukemia.
the MondoA-TXNIP (show TXNIP ELISA Kits) regulatory circuit has a role in the hexose transport curb, although other redundant pathways also contribute
Induction of TXNIP (show TXNIP ELISA Kits) under lactic acidosis is caused by the activation of the glucose-sensing helix-loop-helix transcriptional complex MondoA:Mlx, which is usually triggered upon glucose exposure.
Glucose is required at two additional steps to stimulate the transcription activation function of MondoA-Mlx (show MLX ELISA Kits) complexes.
MondoA is a basic helix-loop-helix/leucine zipper transcription factor (show NRL ELISA Kits) that is expressed predominantly in skeletal muscle. Mice deficient for MondoA excel in sprinting, as their skeletal muscles display an enhanced glycolytic capacity.
MondoA-Mlx (show MLX ELISA Kits) complexes sense elevated levels of G6P and adenine nucleotides to trigger a TXNIP (show TXNIP ELISA Kits)-dependent feedback inhibition of glycolysis
MONDOA forms heterodimers with MLX (MIM 602976) that can bind to and activate transcription from CACGTG E boxes (Billin et al., 2000
MLX interacting protein
, MLX-interacting protein-like
, MLX-interacting protein
, Mlx interactor
, class E basic helix-loop-helix protein 36
, transcriptional activator MondoA