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Acts as a transcriptional repressor.
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Sin3a (show SIN3A Antibodies) mRNA is recruited during maturation and that inhibiting its recruitment not only inhibits development beyond the 2-cell stage but also compromises the fidelity of reprogramming gene expression
Report role of myocardial mSin3A/HDAC1 (show HDAC1 Antibodies)/2 complex in mediating the beneficial effects of exercise in diabetic cardiomyopathy.
SIN3A (show SIN3A Antibodies), generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor (show AHR Antibodies).
Treatment with GlcN, in contrast, inhibits LPS (show TLR4 Antibodies)-ind inflammation and decreased LPS (show TLR4 Antibodies)-mediated recruitment of OGT (show OGT Antibodies), mSin3A, and HDACs.
Within the male germline, Sin3a (show SIN3A Antibodies) is required for the mitotic reentry of gonocytes, but is dispensable for the maintenance of differentiating spermatogonia and subsequent spermatogenic processes.
Sin3A (show SIN3A Antibodies)-deleted testes exhibit a Sertoli-cell only phenotype, consistent with the absolute requirement for Sin3A (show SIN3A Antibodies) in germ cells' development and/or viability.
Sin3 has an important role in the regulation of cell cycle kinetics of the myogenic progenitor cell population
ARID4B (show ARID4B Antibodies) physically interacts with the breast cancer metastasis suppressor BRMS1 (show BRMS1 Antibodies), and we detected differential binding of the Arid4b (show ARID4B Antibodies) alleles to mSIN3A and mSDS3 (show SUDS3 Antibodies)
Results indicate that Sin3a (show SIN3A Antibodies) protects the genomic integrity of pluripotent embryonic cells and governs their unusual cell cycle.
Sin3a (show SIN3A Antibodies) causes deacetylation of c-Myc (show MYC Antibodies) protein to directly repress c-Myc (show MYC Antibodies) activity.
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation.
histone deacetylase complex subunit Sin3a
, paired amphipathic helix protein Sin3a
, transcriptional corepressor Sin3a
, transcriptional regulator, SIN3 yeast homolog A