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May function as a transcription factor with dual roles in transcription initiation and termination. Additionally we are shipping MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) Proteins (7) and and many more products for this protein.
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Human Polyclonal MAZ Primary Antibody for IHC, WB - ABIN2780422
Ray, Shakya, Ray: Vascular endothelial growth factor expression in arthritic joint is regulated by SAF-1 transcription factor. in Journal of immunology (Baltimore, Md. : 1950) 2007
Show all 2 references for ABIN2780422
Human Polyclonal MAZ Primary Antibody for WB - ABIN2778295
Himeda, Ranish, Hauschka: Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes in skeletal and cardiac myocytes. in Molecular and cellular biology 2008
Show all 2 references for ABIN2778295
Human Polyclonal MAZ Primary Antibody for ELISA, WB - ABIN1451364
Pyrc, Moberg, Hall: Isolation of a novel cDNA encoding a zinc-finger protein that binds to two sites within the c-myc promoter. in Biochemistry 1992
Akt (show AKT1 Antibodies) phosphorylates MAZ at Thr385, and the phosphorylated MAZ is released from the p53 (show TP53 Antibodies) promoter, leading to transcriptional activation of p53 (show TP53 Antibodies).
Myc-associated zinc-finger protein (MAZ) was identified as a direct target of miR (show MLXIP Antibodies)-449a, mediating the tumor-suppressive effects.
Studies show a feed-forward regulatory pathway in breast cancer cells where SAF-1 acts as a transcriptional inducer of Ras which in turn increases DNA-binding and transcriptional activities of SAF-1 which in turn, increases transcription of Ras.
In conclusion, our present study indicated that miR (show MLXIP Antibodies)-34c regulated the permeability of BTB via MAZ-mediated expression changes of ZO-1 (show TJP1 Antibodies), occludin (show OCLN Antibodies), and claudin-5 (show CLDN5 Antibodies).
Role of MAZ in prostate cancer and its interaction with androgen receptor (show AR Antibodies) were investigated. siRNA knockdown of AR significantly decreased MAZ expression, and knockdown of MAZ significantly increased the expression of AR.
these findings reveal that SAF-1 is a hitherto unrecognized participant in inducing VEGF expression in triple-negative breast cancer cells, an aggressive form of breast cancer that currently lacks effective treatment options.
relative abundance of SAF-2 plays a critical role in the fine tuned regulation of inflammation-responsive genes that are controlled by SAF-1
epitope spreading between the Tr antigen and the MAZ-DCC (show DCC Antibodies) complex offers a possible model of immune-mediated cerebellar disease.
A novel promoter element was detected in the human MMP1 (show MMP1 Antibodies) gene, and the inflammation-responsive transcription factor SAF-1 was found to interact with it in osteoarthritis
The putative -45 to -39 MYC-associated zinc finger protein-binding site regulates the constitutive activity of human PTHR1 (show PTH1R Antibodies) P2 promoter.
myc (show MYC Antibodies)-associated zinc finger (MAZ) protein was essential for HIF2alpha (show EPAS1 Antibodies) activation of the Cav1 (show CAV1 Antibodies) promoter.
HNF4 (show HNF4A Antibodies)-1 and MAZ-1 regulate the expression of Rho-GDIgamma and contribute to the differentiation of neural stem cells.
These data support a transcription mechanism for murine KRAS that involves MAZ, PARP-1 (show PARP1 Antibodies) and duplex-quadruplex conformational changes in the promoter G-rich nuclease (show DCLRE1C Antibodies) hypersensitive element.
SAF-1 induces VEGF transcription by directly binding to its promoter; markedly higher levels of SAF-1 interaction with the VEGF promoter was detected in the cartilage tissues of arthritic mice as well as human osteoarthritic patients.
These findings are consistent with a previously unrecognized role for MAZ in muscle gene regulation.
May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors.
, myc-associated zinc finger protein
, purine-binding transcription factor
, serum amyloid A activating factor 1
, serum amyloid A activating factor 2
, serum amyloid A-activating factor-1
, transcription factor Zif87
, zinc finger protein 801
, zinc-finger protein, 87 kilodaltons
, serum amyloid A-activating factor SAF-1