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MSR1 encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of MSR1. Additionally we are shipping Macrophage Scavenger Receptor 1 Antibodies (146) and Macrophage Scavenger Receptor 1 Kits (17) and many more products for this protein.
Showing 10 out of 15 products:
Human Macrophage Scavenger Receptor 1 Protein expressed in Human Cells - ABIN2002828
Matsumoto, Naito, Itakura, Ikemoto, Asaoka, Hayakawa, Kanamori, Aburatani, Takaku, Suzuki: Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions. in Proceedings of the National Academy of Sciences of the United States of America 1991
Show all 5 references for ABIN2002828
Human Macrophage Scavenger Receptor 1 Protein expressed in HEK-293 Cells - ABIN2181520
Orloff, Peterson, He, Ganapathi, Heald, Yang, Bebek, Romigh, Song, Wu, David, Cheng, Meltzer, Eng: Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma. in JAMA 2011
Show all 3 references for ABIN2181520
The P275A Polymorphism in the Macrophage Scavenger Receptor 1 Gene is not associated with Prostate Cancer Risk.
Cyr61 (show CYR61 Proteins) promotes CD204 expression and the migration of macrophages via MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) pathway in esophageal squamous cell carcinoma
miR (show MLXIP Proteins)-29a promotes scavenger receptor A expression by targeting QKI (show QKI Proteins) during monocyte-macrophage differentiation.
Heptapeptide XD4 activates the class A scavenger receptor (SR-A) on the glia by increasing the binding of Abeta (show APP Proteins) to SR-A, thereby promoting glial phagocytosis of Abeta (show APP Proteins) oligomer in microglia.
The truncating variant Arg293X in the gene encoding SRA (show SRA1 Proteins)-I/II was associated with reduced lung function and with increased risk of COPD (show ARCN1 Proteins) among men, as well as among alpha1-antitrypsin MZ and superoxide dismutase (show SOD1 Proteins)-3 E1I1 heterozygotes.
monomeric collagen type I via CD204 induces phospho-Akt (show AKT1 Proteins) expression shifting alveolar macrophages to the profibrotic M2 type. Innate immune responses induced by collagen monomers might perpetuate pulmonary fibrosis.
There was a significant negative correlation between the number of CD163 (show CD163 Proteins)(+), CD204(+) or CD206 (show MRC1 Proteins)(+) alveolar macrophages.
rs6966 (3' UTR of PPP1R13L, chr 19q13.32, P = 4.55 x 10(-9)) and rs414580 (intron 2 of MSR1, chr 8p22, P = 6.09 x 10(-8)) were significantly associated with ALL.
Our data suggest that inefficient folding of SR-AI variants with truncated SRCR domain was recognized by the endoplasmic reticulum associated degradation which leads to the immature N- glycosylation and intracellular retention
MSR1 to be a critical component of a TLR3 (show TLR3 Proteins)-mediated pattern recognition receptor response that exerts an antiviral state in both infected and uninfected hepatocytes, thereby limiting the impact of HCV proteins that disrupt IFN signaling in infected cells
Our findings demonstrated that ClC-3 (show CLCN3 Proteins) deficiency inhibits atherosclerotic lesion development, possibly via suppression of JNK (show MAPK8 Proteins)/p38 MAPK (show MAPK14 Proteins) dependent SR-A expression and foam cell formation
FAP (show FAP Proteins)-cleaved collagen is a substrate for SR-A-dependent macrophage adhesion.
Macrophages regulate FX plasma levels in an SR-AI-dependent manner.
The results of this results reveal that SRA has important clinical implications for TLR-targeted immunotherapeutical strategy in intracerebral hemorrhage.
these findings suggest that SR-A-mediated dsRNA internalization is independent of innate antiviral signaling.
Our findings imply that SR-A may be an important target for improving therapeutic strategies for type 1 diabetes.
Heptapeptide XD4 activates the class A scavenger receptor (SR-A) on the glia by increasing the binding of Abeta (show APP Proteins) to SR-A, thereby promoting glial phagocytosis of Abeta (show APP Proteins) oligomer in an immortalized microglia cell line.
SR-A does not induce cytokine production, but mediates inhibition of LPS (show TLR4 Proteins)-stimulated production of IL-6 (show IL6 Proteins) and IL-12 (show IL12A Proteins)
The antagonism between SR-A and RAGE (show AGER Proteins) contributes to the pathogenesis of diabetic retinopathy by nurturing a disease-prone macrophage phenotype.
our data indicate that SR-A localizes in LRs and that LRs are required to couple SR-A to PLA2 (show PLA2G2A Proteins) activation during SRA-mediated macrophage attachment.
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
macrophage scavenger receptor 1
, macrophage scavenger receptor types I and II-like
, macrophage acetylated LDL receptor I and II
, macrophage scavenger receptor type III
, macrophage scavenger receptor types I and II
, scavenger receptor class A member 1
, scavenger receptor class A, member 1
, scavenger receptor type A
, macrophage scavenger receptor type I