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Major Histocompatibility Complex, Class II, DM alpha Proteins (HLA-DMA)

HLA-DMA belongs to the HLA class II alpha chain paralogues. Additionally we are shipping Major Histocompatibility Complex, Class II, DM alpha Antibodies (33) and Major Histocompatibility Complex, Class II, DM alpha Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID
Rat HLA-DMA HLA-DMA 294274
Mouse HLA-DMA HLA-DMA 14998
HLA-DMA 3108
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Top Major Histocompatibility Complex, Class II, DM alpha Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

HLA-DMA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA) Interaction Partners

Human Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA) interaction partners

  1. DMA*01:01 (69.35%) and DMB*01:01 (52.5%) alleles were more frequent in Chinese Hans

  2. HLA DMA and DMB show no association with rheumatoid arthritis in US Caucasians.

  3. The results suggest that HLA-DMA*0104 may represent a novel allele of susceptibility to systemic lupus erythematosus.

  4. HLA-DMA may play an important role in pathogenesis of type 1 diabetes, and clinical status heterogeneity of type 1 diabetes may be related to genetic mechanism.

  5. The absence of HLA-DR/DM interactions at the limiting membrane prevents local loading of MHC class II molecules in phagosomes

  6. glycosylation promotes, but is not essential for, DMalphabeta ER exit; single DMalpha chains cannot fully oxidize without DMbeta (show GPHb5 Proteins), while DMbeta (show GPHb5 Proteins) forms disulfide-linked homodimers without DMalpha

Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA) Protein Profile

Protein Summary

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.

Gene names and symbols associated with HLA-DMA

  • RT1 class II, locus DMa (RT1-DMa)
  • SLA-DM alpha chain (SLA-DMA)
  • major histocompatibility complex, class II, DM alpha (HLA-DMA)
  • histocompatibility 2, class II, locus DMa (H2-DMa)
  • D6S222E protein
  • DMA protein
  • H-2Ma protein
  • H2-Ma protein
  • HLA-DMA protein
  • HLADM protein
  • RING6 protein
  • RT1.DMa protein
  • RT1.Ma protein

Protein level used designations for HLA-DMA

RT1 class II, DM alpha , MHC class II-like alpha chain , major histocompatibility complex, class II, DM alpha , H2-M alpha , class II histocompatibility antigen, M alpha chain , histocompatibility 2, class II, locus Ma , HLA class II histocompatibility antigen, DM alpha chain , MHC class II antigen DMA , really interesting new gene 6 protein

GENE ID SPECIES
294274 Rattus norvegicus
445528 Sus scrofa
481732 Canis lupus familiaris
14998 Mus musculus
3108 Homo sapiens
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