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MVP encodes the major component of the vault complex. Additionally we are shipping Major Vault Protein Antibodies (143) and Major Vault Protein Proteins (6) and many more products for this protein.
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structure and cellular localization during embryonic development; findings indicate a dramatic relocalization of MVP from the cytoplasm to the nucleus during sea (show Slc25a1 ELISA Kits) urchin embryogenesis
MVP genetic polymorphisms and haplotypes may not be associated with drug resistance of partial epilepsy in the Chinese Han population.
NSCLCs [ non-small cell lung cancer ] expressing P-gp (show ABCB4 ELISA Kits) [P-glycoprotein ]/LRP (show RPSA ELISA Kits) [ lung resistance-related protein] bear the EGFR (show EGFR ELISA Kits) [epidermal growth factor receptor (show EGFR ELISA Kits)] mutation in exon 19 or 21 easily.
The association of MVP amplification and PTEN deletion could be a potential biomarker in glioblastoma.
Bag3 (show BAG3 ELISA Kits)-MVP is an important complex that regulates a potent prosurvival signaling pathway and contributes to chemotherapy resistance in breast cancer
LDL increases ABCB1 (show ABCB1 ELISA Kits), ABCC1 (show ABCC1 ELISA Kits), and LRP (show RPSA ELISA Kits) expression in a human doxorubicin-resistant uterine sarcoma cell line.
Study demonstrates that vaults have a tumour-promoting potential by stabilizing EGFR (show EGFR ELISA Kits)/PI3K (show PIK3CA ELISA Kits)-mediated migration and survival pathways in human glioblastoma.
USF1 (show USF1 ELISA Kits) binding to an E-box element may be critical for basal MVP promoter activation.
hyperosmotic stress upregulates Sp1 (show PSG1 ELISA Kits) expression levels by inhibiting ubiquitination through the activation of JNK (show MAPK8 ELISA Kits), and the induction of Sp1 (show PSG1 ELISA Kits) expression directly enhances MVP transcription.
the protein levels of MVP, TEP1 and vPARP (show PARP4 ELISA Kits) are actually increased in the highergrade tumors suggesting existence of post-transcriptional regulation of vault component production.
Lung resistance-related protein is associated with malignant ascitic cells and recurrence in ovarian serous carcinoma.
MVP may fine-tune SR-A (show MSR1 ELISA Kits) activity in macrophages which contributes to the development of atherosclerosis
MVP is hijacked by L. monocytogenes in order to counteract the autophagy process, a finding that could have major implications in deciphering the cellular role of vault particles.
These results suggest that up-regulation of MVP in multi-drug resistance (MDR) may involve chromatin remodeling.
Results suggest that major vault protein functions as a novel scaffold protein (show HOMER1 ELISA Kits) for both SHP-2 (show PTPN11 ELISA Kits) and Erk (show EPHB2 ELISA Kits).
results suggest that MVP makes a substantial contribution to epithelial cell-mediated resistance to infection
The crystal structure of the vault particle solved at 8 A resolution, together with the 2.1-A structure of the seven N-terminal domains (R1-R7) of MVP, provide an explanation for a reversible dissociation induced by low pH.
MVP is beneficial for functional recovery and axonal regrowth after spinal cord injury in adult zebrafish.
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.
major vault protein
, major vault protein-alpha
, major vault protein B
, lung resistance-related protein
, lung resistance-associated protein
, protein tyrosine phosphatase alpha
, protein-tyrosine phosphatase alpha
, receptor-type tyrosine-protein phosphatase alpha