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Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Additionally we are shipping Mannose Phosphate Isomerase Kits (17) and Mannose Phosphate Isomerase Proteins (13) and many more products for this protein.
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MPI deficiencies resulted in 50% embryonic lethality by 4 dpf. Multi-systemic abnormalities, including small eyes, dysmorphic jaws (show IMPAD1 Antibodies), pericardial edema, a small liver and curled (show CCRN4L Antibodies) tails, occurred in 82% of the surviving larvae.
Data indicate that reduced phosphomannose isomerase (MPI) alters mannose flux in hypomorphic mice.
Phosphomannose isomerase activity and mRNA levels increased at 1 month, and the values in the ileum were lower than in jejunum.
Results suggest that mannose toxicity in phosphomannose isomerase(-/-) embryos is caused by mannose-6-P accumulation, which inhibits glucose metabolism and depletes intracellular ATP.
Data conclude that PMI-null cells can salvage mannose from both endogenous and external glycoconjugates via lysosomal and nonlysosomal degradation pathways.
Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts
Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib.
, mannose phosphate isomerase
, mannose-6-phosphate isomerase-like
, mannose phosphate isomerase 1
, phosphomannose isomerase
, mannose-6- phosphate isomerase
, phosphomannose isomerase 1
, mannosephosphate isomerase