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Mannose Receptor, C Type 2 Proteins (MRC2)

MRC2 encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. Additionally we are shipping MRC2 Antibodies (50) and MRC2 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat MRC2 MRC2 498011 Q4TU93
MRC2 9902 Q9UBG0
MRC2 17534 Q64449
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Top MRC2 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MRC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
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More Proteins for Mannose Receptor, C Type 2 (MRC2) Interaction Partners

Cow (Bovine) Mannose Receptor, C Type 2 (MRC2) interaction partners

  1. A second loss-of-function mutation in the bovine mannose receptor C (MRC2) gene causes illegitimate receptor oligomerization, which is predicted to impair function of the MRC2 encoded protein, Endo180.

  2. The positional identification of a 2-bp deletion in the open reading frame of the MRC2 receptor causing the recessive Crooked (show LRP6 Proteins) Tail Syndrome in cattle, isdescribed.

Human Mannose Receptor, C Type 2 (MRC2) interaction partners

  1. A model of the ligand-binding region of uPARAP was obtained by molecular replacement.

  2. The positive correlation between suPLAUR expression and body mass index, suggests that leukocyte recruitment in obese tissue may be regulated, at least in part, through the splicing of the PLAUR (show PLAUR Proteins) transcript.

  3. Our findings identify sarcoma cell-resident uPARAP/Endo180 as a central player in the bone degeneration of advanced osteosarcoma

  4. Study identifies the interaction between lectin domain in Endo180 and CD147 (show BSG Proteins) as an Epithelial-to-mesenchymal transition suppressor and indicates that stabilization of this molecular complex improves prostate cancer survival rates.

  5. AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed prostate epithelial cells via Endo180 pathway linked to cancer progression.

  6. MRC2 is downregulated by UVA irradiation and reduces collagen internalization; this can be recovered by all-trans retinoic acid

  7. Our findings correlate for the first time impaired collagen uptake via Endo180 with the pericellular accumulation of collagen fragments during photoaging.

  8. TGFbeta1 (show TGFB1 Proteins)-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis.

  9. A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor (show ITGA2 Proteins) uparap/ENDO180.

  10. Our present study suggests that uPARAP may be involved in glioma cell invasiveness through actin cytoskeletal rearrangement

Mouse (Murine) Mannose Receptor, C Type 2 (MRC2) interaction partners

  1. Our findings identify sarcoma cell-resident uPARAP/Endo180 as a central player in the bone degeneration of advanced osteosarcoma

  2. AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed prostate epithelial cells via Endo180 pathway linked to cancer progression.

  3. uPARAP function in cutaneous wound repair

  4. Both uPARAP and MMP-2 (show MMP2 Proteins) take part in matrix turnover processes important for bone growth.

  5. Genetic ablation of the Mrc2 impaired the intracellular collagen degradation pathway.

  6. This function of uPARAP/Endo180 defines a novel role of intracellular collagen turnover in fibrosis protection.

  7. uPARAP is highly expressed in the murine lung, and loss of uPARAP leads to differences in lung mechanics, lung permeability, and collagen content after injury

  8. data establish an important fibrosis-attenuating role for Mrc2-expressing renal interstitial cells and suggest the involvement of a lysosomal collagen turnover pathway

  9. A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor (show ITGA2 Proteins) uparap/ENDO180.

  10. targeted deletion of Endo180 exons 2-6 results in cells that have a defect in collagen binding and internalization and an impaired migratory phenotype

MRC2 Protein Profile

Protein Summary

This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease.

Gene names and symbols associated with MRC2

  • mannose receptor, C type 2 (MRC2)
  • mannose receptor, C type 2 (mrc2)
  • mannose receptor, C type 2 (Mrc2)
  • CD280 protein
  • CLEC13E protein
  • ENDO180 protein
  • mKIAA0709 protein
  • MRC2 protein
  • uPARAP protein

Protein level used designations for MRC2

mannose receptor, C type 2 , C-type mannose receptor 2 , C-type mannose receptor 2-like , collagen-binding factor Endo180 , endocytic receptor 180 , macrophage mannose receptor 2 , C-type lectin domain family 13 member E , UPAR-associated protein , endocytic receptor (macrophage mannose receptor family) , urokinase-type plasminogen activator receptor-associated protein , lectin lambda , novel lectin

GENE ID SPECIES
454788 Pan troglodytes
529049 Bos taurus
100004793 Danio rerio
100036697 Xenopus (Silurana) tropicalis
100406333 Callithrix jacchus
100541638 Meleagris gallopavo
498011 Rattus norvegicus
9902 Homo sapiens
17534 Mus musculus
100688560 Canis lupus familiaris
100516106 Sus scrofa
419950 Gallus gallus
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