anti-Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) Antibodies

M6PR encodes a member of the P-type lectin family. Additionally we are shipping M6PR Proteins (10) and M6PR Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
M6PR 16004 Q07113
M6PR 4074 P20645
M6PR 312689 Q6AY20
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Top anti-M6PR Antibodies at

Showing 10 out of 71 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-M6PR Antibody Titration: </b>5.0ug/ml<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated FACS, IF, WB M6PR Antibody (C-term) (ABIN650726) western blot analysis in A549 cell line lysates (35 µg/lane).This demonstrates the M6PR antibody detected the M6PR protein (arrow). M6PR Antibody (C-term) (ABIN650726) flow cytometric analysis of A549 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated EIA, IHC (p) 0.4 mL Log in to see 6 to 8 Days
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of M6PR Antibody (N-term)(ABIN389291) in mouse brain tissue lysates (35 µg/lane). M6PR (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human testis tissue reacted with M6PR antibody (N-term) (ABIN389291), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
Cow Goat Un-conjugated ELISA   0.1 mg Log in to see 7 to 9 Days
Mouse Rabbit Un-conjugated IHC, WB WB on rat brain lysate using Rabbit antibody to internal region of MPRD (Cation dependent mannose-6-phosphate receptor): whole serum (ABIN350471) at 1 : 1000 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the detected band. 100 μL Log in to see 7 to 8 Days
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (33.48 KDa) . 50 μL Log in to see 11 to 12 Days
Dog Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
Bat Goat Un-conjugated ELISA   100 μg Log in to see 7 to 9 Days

M6PR Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) , ,
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Rat (Rattus) , ,
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Top referenced anti-M6PR Antibodies

  1. Cow (Bovine) Polyclonal M6PR Primary Antibody for ELISA - ABIN408673 : Frei, Jeon, Kilcher, Moest, Henning, Jost, Plückthun, Mercer, Aebersold, Carreira, Wollscheid: Direct identification of ligand-receptor interactions on living cells and tissues. in Nature biotechnology 2012 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal M6PR Primary Antibody for ELISA, WB - ABIN561704 : Steffan, Williams, Welbourne, Cardelli: HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na+-H+ exchangers. in Journal of cell science 2010 (PubMed)
    Show all 2 Pubmed References

More Antibodies against M6PR Interaction Partners

Zebrafish Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) interaction partners

  1. Analysis of full-length sequences for MPR 46 from zebrafish (Danio rerio) and its functional analysis.

Rhesus Monkey Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) interaction partners

  1. Rotaviruses reach late endosomes and require M6PR and cathepsin proteases to enter the cell.

Mouse (Murine) Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) interaction partners

  1. Selective M6PR down-regulation has a critical role in CD8 (show CD8A Antibodies)(+) T cell survival.

  2. Expression of imprinted gene Igf2r (show IGF2R Antibodies) was unregulated in haploid androgenetic/gynogenetic blastocysts.

  3. that an elevation in IGF-II receptor (show IGF2R Antibodies) levels can influence the expression profiles of transcripts as well as proteins that are involved in AD pathogenesis.

  4. DNA methylation (show HELLS Antibodies) changes were noted in the Igf2r (show IGF2R Antibodies) gene during chronic cystitis in a murine model.

  5. Airn expression is both necessary and sufficient to silence Igf2r (show IGF2R Antibodies) throughout embryonic stem cell differentiation.

  6. We conclude that M6PR is an important receptor used by HIV-1 to cross the blood-brain barrier.

  7. The results excluded a role for spliced and unspliced Airn lncRNA products and for Airn nuclear size and location in silencing Igf2r. Instead, silencing only required Airn transcriptional overlap of the Igf2r promoter, which interferes with RNA polymerase II recruitment in the absence of repressive chromatin.

  8. mannose 6-phosphate/IGF2R knock-down in receptor-positive mouse hepatocytes causes increased cathepsin secretion as well as enhanced cell motility and invasiveness

  9. enhanced CI-MPR (show IGF2R Antibodies) expression might improve the efficacy of enzyme replacement therapy in Pompe disease through enhancing receptor-mediated uptake of GAA (show GAA Antibodies).

  10. The interaction of sM6P/IGF2R (show IGF2R Antibodies) with Plg (show PLG Antibodies) may be an important regulatory mechanism to inhibit migration of cells using the uPA (show PLAU Antibodies)/uPAR (show PLAUR Antibodies) system.

Human Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) interaction partners

  1. In light of existing report suggesting critical role of Nef-GCC185 (show GCC2 Antibodies) interaction reveals valuable mechanistic insights affecting specific protein transport pathway in docking of late endosome derived Rab9 (show RAB9A Antibodies) bearing transport vesicle at TGN (show TG Antibodies) elucidating role of Nef during viral pathogenesis.

  2. Results suggest that Rab (show HRB Antibodies) protein Rab29 (show RAB7L1 Antibodies) is essential for the integrity of the trans-Golgi network (TGN (show TG Antibodies)) and participates in the retrograde trafficking of mannose-6-phosphate receptor (M6PR).

  3. These data indicate that clathrin is required for the function of AP-1 (show FOSB Antibodies)- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.

  4. Sortilin (show SORT1 Antibodies) is a new alpha-Gal A receptor expressed in renal endothelial cells and that this receptor together with the M6PR (show IGF2R Antibodies) is able to internalize circulating alpha-Gal A.

  5. Mannose receptor (MR) engagement by mesothelin (show MSLN Antibodies) GPI (show GNPDA1 Antibodies) anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody

  6. sorting of the CD-MPR in late endosomes requires a distinct di-aromatic motif with only limited possibilities for variations

  7. We conclude that the CI-MPR (show IGF2R Antibodies) participates in lysosomal and granular targeting of serglycin (show SRGN Antibodies) and basic proteins such as lysozyme (show LYZ Antibodies) associated with the proteoglycan (show Vcan Antibodies) in hematopoietic cells.

  8. sortilin (show SORT1 Antibodies) and mannose-6-phosphate receptors recycle to the TGN (show TG Antibodies) in SNX1 (show SNX1 Antibodies)-dependent carriers, which we named endosome-to-TGN (show TG Antibodies) transport carriers

  9. Missorting of cathepsin D (show CTSD Antibodies) in GARP (show CNGB1 Antibodies)-depleted cells results from accumulation of recycling MPRs in a population of light, small vesicles downstream of endosomes.

  10. Data demonstrate that Rab31 (show RAB31 Antibodies) is required for transport of mannose 6-phosphate receptors from the trans-Golgi network to endosomes and for the Golgi/TGN (show TG Antibodies) organization.

Cow (Bovine) Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) interaction partners

  1. Rotaviruses reach late endosomes and require M6PR and cathepsin proteases to enter the cell.

  2. Expression and binding properties of mannose-6-phosphate receptors CD-MPR and CI-MPR (show IGF2R Antibodies) differ during perinatal development in rat liver.

M6PR Antigen Profile

Protein Summary

This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.

Gene names and symbols associated with M6PR

  • mannose-6-phosphate receptor (cation dependent) L homeolog (m6pr.L) antibody
  • mannose-6-phosphate receptor, cation dependent (M6PR) antibody
  • mannose-6-phosphate receptor (cation dependent) (m6pr) antibody
  • mannose-6-phosphate receptor (cation dependent) S homeolog (m6pr.S) antibody
  • mannose-6-phosphate receptor (cation dependent) (Ethha_1678) antibody
  • Cation-dependent mannose-6-phosphate receptor (mprd) antibody
  • insulin-like growth factor 2 receptor (Igf2r) antibody
  • mannose-6-phosphate receptor, cation dependent (M6pr) antibody
  • AI661837 antibody
  • CD-MPR antibody
  • CD222 antibody
  • CDMPR antibody
  • CI-MPR antibody
  • M6P/IGF2R antibody
  • M6PR antibody
  • MGC68896 antibody
  • MGC89423 antibody
  • MGC130765 antibody
  • MPR-46 antibody
  • MPR 46 antibody
  • Mpr46 antibody
  • Mpr300 antibody
  • mprd antibody
  • SMPR antibody
  • wu:fj81h11 antibody
  • zgc:77757 antibody

Protein level used designations for M6PR

mannose-6-phosphate receptor (cation dependent) , Mannose 6-Phosphate Receptor , cation-dependent mannose-6-phosphate receptor , CD-MPR , Cation-dependent mannose-6-phosphate receptor , 300 kDa mannose 6-phosphate receptor , CI Man-6-P receptor , IGF-II receptor , IGF-II/CI-MPR , M6P/IGF2 receptor , M6PR , MPR 300 , cation-independent MPR , cation-independent mannose 6-phosphate receptor , cation-independent mannose-6-phosphate receptor , insulin-like growth factor II receptor , mannose-6-phosphate receptor, cation independent , 46-kDa mannose 6-phosphate receptor , CD Man-6-P receptor , Mr 46,000 Man6PR , small mannose 6-phosphate receptor , 46 kDa mannose 6-phosphate receptor , MPR 46

380564 Xenopus laevis
396044 Gallus gallus
406486 Danio rerio
493477 Xenopus (Silurana) tropicalis
496207 Xenopus laevis
716696 Macaca mulatta
736013 Pan troglodytes
10092655 Ethanoligenens harbinense YUAN-3
100194796 Salmo salar
16004 Mus musculus
4074 Homo sapiens
477700 Canis lupus familiaris
281291 Bos taurus
312689 Rattus norvegicus
17113 Mus musculus
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