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Mannosidase, Alpha, Class 2B, Member 1 Proteins (MAN2B1)

MAN2B1 encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Additionally we are shipping Mannosidase, Alpha, Class 2B, Member 1 Antibodies (10) and Mannosidase, Alpha, Class 2B, Member 1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MAN2B1 17159 O09159
Rat MAN2B1 MAN2B1 361378  
MAN2B1 4125 O00754
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Top Mannosidase, Alpha, Class 2B, Member 1 Proteins at antibodies-online.com

Showing 4 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MAN2B1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) Interaction Partners

Mouse (Murine) Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) interaction partners

  1. Mannose receptor (-/-) liver sinusoidal endothelial cells had markedly and significantly reduced enzyme activities for four out of five lysosomal enzymes tested, i.e., cathepsin-D, alpha-mannosidase, beta-hexosaminidase and arylsulfatase.

Human Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) interaction partners

  1. A novel heterozygous mutation (c.2013G>A; p.R638H) of MANBA (show MANBA Proteins) was identified in patients with autosomal-dominant nystagmus. An additional mutation (c.2346T>A; p.L749H) in MANBA (show MANBA Proteins) was found by screening patients with sporadic nystagmus.

  2. Our results indicate a correlation between the MAN2B1 genotypes and the cognitive function, upper limb coordination, balance, FVC% and the storage of oligosaccharides in CSF (show CSF2 Proteins).

  3. The results showed that the alpha-mannosidosis patient has compound heterozygous mutations in the MAN2B1 gene

  4. MAN2B1 is targeted to the vacuole without passing through the Golgi complex.

  5. Expressed MAN2B1 and MAN2B2 (show MAN2B2 Proteins) in Drosophila S2 cells and functionally characterized them. MAN2B1 and MAN2B2 (show MAN2B2 Proteins) were significantly inhibited by the class II alpha-mannosidase inhibitors, swainsonine and mannostatin A.

  6. 5 new mutations were found in the MAN2B1 gene: c.157G>T, c.562C>T, c.599A>T, c.293dupA, c.2402G>A (p.E53X, p.R188X, p.H200L, p.Y99VfsX61, p.G801D). p.H200L could involve the catalytic mechanism. p.G801D would affect correct folding.

Cow (Bovine) Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) interaction partners

Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) Protein Profile

Protein Summary

This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MAN2B1

  • mannosidase, alpha, class 2B, member 1 (MAN2B1)
  • mannosidase, alpha, class 2B, member 1 (man2b1)
  • mannosidase 2, alpha B1 (Man2b1)
  • mannosidase, alpha, class 2B, member 1 (Man2b1)
  • AW107687 protein
  • Laman protein
  • MANB protein

Protein level used designations for MAN2B1

mannosidase, alpha, class 2B, member 1 , lysosomal alpha-mannosidase (109.3 kD) (XF355) , lysosomal alpha-mannosidase , lysosomal alpha-mannosidase-like , lysosomal acid alpha-mannosidase , mannosidase alpha class 2B member 1 , mannosidase alpha-B , mannosidase 2, alpha B1 , mannosidase, alpha B, lysosomal , laman

GENE ID SPECIES
484932 Canis lupus familiaris
779924 Xenopus (Silurana) tropicalis
100010377 Monodelphis domestica
100174476 Pongo abelii
100395073 Callithrix jacchus
100598622 Nomascus leucogenys
17159 Mus musculus
100718205 Cavia porcellus
361378 Rattus norvegicus
4125 Homo sapiens
282272 Bos taurus
493697 Felis catus
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