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Mannosyl (Alpha-1,6-)-Glycoprotein beta-1,6-N-Acetyl-Glucosaminyltransferase Proteins (MGAT5)

The protein encoded by MGAT5 belongs to the glycosyltransferase family. Additionally we are shipping MGAT5 Antibodies (44) and MGAT5 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MGAT5 107895 Q8R4G6
MGAT5 4249 Q09328
Rat MGAT5 MGAT5 65271 Q08834
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Top MGAT5 Proteins at

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 59 to 64 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 59 to 64 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

MGAT5 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
Human , , ,
, ,

Top referenced MGAT5 Proteins

  1. Human MGAT5 Protein expressed in Human Cells - ABIN2004248 : Soleimani, Roder, Dennis, Lipina: Beta N-acetylglucosaminyltransferase V (Mgat5) deficiency reduces the depression-like phenotype in mice. in Genes, brain, and behavior 2008 (PubMed)

More Proteins for Mannosyl (Alpha-1,6-)-Glycoprotein beta-1,6-N-Acetyl-Glucosaminyltransferase (MGAT5) Interaction Partners

Mouse (Murine) Mannosyl (Alpha-1,6-)-Glycoprotein beta-1,6-N-Acetyl-Glucosaminyltransferase (MGAT5) interaction partners

  1. Expression of GnT-V was also elevated in bleomycin (BLM)-injected sclerotic skin, and MGAT5(-/-) mice were resistant to BLM-induced skin sclerosis with reduced collagen type 1 alpha1 content.

  2. GnT-V regulates the canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway by modulating N-glycosylation of Wnt (show WNT2 Proteins) receptors, which changes cancer stem cells in colorectal tumors, causing altered colon tumorigenesis and adenoma progression in Apc (show APC Proteins)(min/+) mice

  3. this study suggests that the GnT-V expression is inversely correlated with radiation sensitivity in prostate cancer(PCa (show ENPP1 Proteins))cells

  4. The GnT-V prevented steatohepatitis progression through modulating lymphocyte and HSC (show FUT1 Proteins) functions.

  5. GnT-V overexpression promotes EMT (show ITK Proteins) and keratinocyte migration in part through enhanced EGF receptor (show EGFR Proteins) signaling.

  6. Mgat5-dependent glycosylation of proteins can modulate acquired immune responses, but it is not essential for the development of OVA-induced eosinophilic airway inflammation.

  7. GnT-V expression and its branched glycan products effectively modulate her-2 (show ERBB2 Proteins)-mediated signaling pathways that, in turn, regulate the relative proportion of tumor initiating cells and the latency of her-2 (show ERBB2 Proteins)-driven tumor onset

  8. A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (show MGAT5B Proteins) (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase (show GTDC2 Proteins) activity.

  9. expression of Mgat5 sensitized cells to multiple cytokines;Galectin-3 (show LGALS3 Proteins) cross-linked Mgat5-modified N-glycans on epidermal growth factor (show EGF Proteins) and transforming growth factor-beta receptors at the cell surface and delayed their removal by constitutive endocytosis

  10. fibroblast N-acetylglucosaminyltransferase V regulates alpha5beta1 integrin expression mediated by the protein kinase C signaling pathway

Human Mannosyl (Alpha-1,6-)-Glycoprotein beta-1,6-N-Acetyl-Glucosaminyltransferase (MGAT5) interaction partners

  1. role in the inhibition of trophoblast cell invasion and migration during early pregnancy by direct or indirect regulation of MMP2 (show MMP2 Proteins)/9 activity

  2. the level of TGFBR1 and early osteogenic differentiation were abolished in the DPSCs transfected with siRNA for GnT-V knockdown...GnT-V plays a critical role in the hexosamine-induced activation of TGF-b signaling and osteogenic differentiation

  3. binding of recombinant Gal-3 (show LGALS3 Proteins) to the RPE (show RPE Proteins) cell surface and inhibitory effects on RPE (show RPE Proteins) attachment and spreading largely dependent on interaction with Mgat5 modified N-glycans

  4. Mgat5 plays an important role in early spontaneous miscarriage in humans.

  5. Gnt-V caused tumour growth more quickly

  6. High expression of GnT-V was observed in infiltrating cells in skin section samples from systemic and localized patients with scleroderma.

  7. MGAT5 protein and gene expression in in uveal and cutaneous melanoma cells

  8. UDP-galactose (show B4GALT1 Proteins) (SLC35A2 (show SLC35A2 Proteins)) and UDP-N-acetylglucosamine (show MGAT4B Proteins) (SLC35A3 (show SLC35A3 Proteins)) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats).

  9. Human Mgat5 increases amino acid uptake, intracellular levels of glycolytic and TCA intermediates, as well as HEK293 cell growth.

  10. Study disclose that a deficiency in branched N-glycosylation on TCR due to a reduced MGAT5 gene expression is a new molecular mechanism underlying UC pathogenesis.

MGAT5 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies.

Gene names and symbols associated with MGAT5

  • alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A-like (LOC100760162)
  • mannoside acetylglucosaminyltransferase 5 (Mgat5)
  • mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (MGAT5)
  • mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (Mgat5)
  • 4930471A21Rik protein
  • 5330407H02Rik protein
  • AI480971 protein
  • GlcNAc-TV protein
  • GNT-V protein
  • GNT-VA protein
  • MGAT5 protein

Protein level used designations for MGAT5

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A , Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase , GlcNAc-T V , Mannoside acetylglucosaminyltransferase 5 , GNT-V , N-acetylglucosaminyl-transferase V , alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A , alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase , beta1,6N-acetylglucosaminyltransferase V , glcNAc-T V , mannoside acetylglucosaminyltransferase 5 , N-acetylglucosaminyltransferase V , alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase

100760162 Cricetulus griseus
107895 Mus musculus
4249 Homo sapiens
65271 Rattus norvegicus
101107672 Ovis aries
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