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Maternal Embryonic Leucine Zipper Kinase Proteins (MELK)

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Additionally we are shipping MELK Antibodies (115) and MELK Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MELK 9833 Q14680
MELK 17279 Q61846
Rat MELK MELK 362510  
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Top MELK Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details

MELK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Maternal Embryonic Leucine Zipper Kinase (MELK) Interaction Partners

Human Maternal Embryonic Leucine Zipper Kinase (MELK) interaction partners

  1. targeting MELK by the inhibition of both its catalytic activity and its protein stability might sensitize tumours to DNA-damaging agents or radiation therapy by lowering the DNA-damage threshold

  2. Together, these data indicate that MELK is a normally non-essential kinase, but is critical for basal-like breast cancer.

  3. EZH2 (show EZH2 Proteins) protects glioma stem cells from radiation-induced cell death in a MELK/FOXM1 (show FOXM1 Proteins)-dependent manner

  4. we report characterization of possible roles of MELK in acute myeloid leukemia (show BCL11A Proteins)

  5. insight has been brought by the discovery of a protein complex of FOXM1 (show FOXM1 Proteins) with the mitotic kinase MELK in cancer stem cells in brain cancers, as this protein complex appears to be cancer-specific

  6. advanced cancers with OTSSP167 started in 2013, as the first-in-class MELK inhibitor. This review summarizes the current molecular understanding of MELK and the recent preclinical studies about MELK as a cancer therapeutic target.

  7. MELK promotes cell migration and invasion via the FAK (show PTK2 Proteins)/Paxillin (show PXN Proteins) pathway, and plays an important role in the occurrence and development of gastric cancer.

  8. our current knowledge of MELK function and recent discoveries in MELK signaling pathway were discussed.

  9. The structural and biochemical analyses unravel the molecular mechanisms for the autophosphorylation/activation of MELK and the dependence of its catalytic activity on reducing agents.

  10. glioblastoma cells have elevated MELK protein levels to better cope with replication stress during unperturbed S phase.

Mouse (Murine) Maternal Embryonic Leucine Zipper Kinase (MELK) interaction partners

  1. MELK promotes cell migration and invasion via the FAK (show PTK2 Proteins)/Paxillin (show PXN Proteins) pathway, and plays an important role in the occurrence and development of gastric cancer.

  2. Phosphorylation of the activation loop of MPK38 induces its movement resulting in kinase activation.

  3. These results indicate that Trx (show TXN Proteins) functions as a physiological inhibitor of MPK38, which plays an important role in inducing ASK1 (show MAP3K5 Proteins)-, TGF-beta (show TGFB1 Proteins), and p53 (show TP53 Proteins)-mediated activity

  4. an important role for MPK38-mediated phosphorylation of PDK1 (show PDPK1 Proteins) in the negative regulation of PDK1 (show PDPK1 Proteins) activity.

  5. MPK38 may act as a novel regulator for promoting p53 (show TP53 Proteins) activity through direct phosphorylation of p53 (show TP53 Proteins) at Ser (show SIGLEC1 Proteins)(15).

  6. Upregulation of maternal embryonic leucine zipper kinase is associated with mammary tumor.

  7. MELK is necessary for proliferation of embryonic and postnatal MNP and suggest that it regulates the transition from GFAP (show GFAP Proteins)-expressing progenitors to rapid amplifying progenitors in the postnatal brain.

  8. The characterization of two novel E2F (show E2F1 Proteins) target genes, chromosome condensation-related SMC-associated protein 1 (Cnap1 (show NCAPD2 Proteins)) and maternal embryonic leucine zipper kinase (Melk) is reported.

  9. MPK38 physically interacts with ASK1 (show MAP3K5 Proteins) in vivo and acts as a positive upstream regulator of ASK1 (show MAP3K5 Proteins)

Zebrafish Maternal Embryonic Leucine Zipper Kinase (MELK) interaction partners

  1. Melk-like gene may play a role in primitive hematopoiesis by affecting the expression of genes critical for hematopoiesis.

Xenopus laevis Maternal Embryonic Leucine Zipper Kinase (MELK) interaction partners

  1. Overexpression of xMELK leads to failure of cytokinesis and impairs accumulation RhoA- a pivotal regulator of cytokinesis.

  2. These results demonstrate the presence of a mitochondrial targeting signal at the N-terminus of the MC domain of MELK. This mitochondrial targeting signal was also functional in human HeLa cells.[MELK]

MELK Protein Profile

Protein Summary

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis.

Gene names and symbols associated with MELK

  • maternal embryonic leucine zipper kinase (MELK)
  • maternal embryonic leucine zipper kinase (melk)
  • maternal embryonic leucine zipper kinase (cgd5_2270)
  • maternal embryonic leucine zipper kinase (Melk)
  • AI327312 protein
  • fb71b01 protein
  • fe01f04 protein
  • HPK38 protein
  • Melk protein
  • mKIAA0175 protein
  • MPK38 protein
  • wu:fb71b01 protein
  • wu:fe01f04 protein
  • xmelk protein

Protein level used designations for MELK

maternal embryonic leucine zipper kinase , maternal embryonic leucine zipper kinase-like , pEg3 kinase , protein kinase Eg3 , protein kinase PK38 , tyrosine-protein kinase MELK , zMelk , Protein kinase Eg3

GENE ID SPECIES
428391 Gallus gallus
465095 Pan troglodytes
549144 Xenopus (Silurana) tropicalis
3373320 Cryptosporidium parvum Iowa II
100123808 Nasonia vitripennis
100386947 Callithrix jacchus
100586707 Nomascus leucogenys
9833 Homo sapiens
481608 Canis lupus familiaris
520088 Bos taurus
17279 Mus musculus
362510 Rattus norvegicus
30724 Danio rerio
397927 Xenopus laevis
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