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MATN2 encodes a member of the von Willebrand factor A domain containing protein family. Additionally we are shipping Matrilin 2 Antibodies (41) and Matrilin 2 Kits (3) and many more products for this protein.
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Matrilin-2 induces post-burn inflammatory responses as an endogenous danger signal, partly through a TLR4 (show TLR4 Proteins)-mediated mechanism
matrilin-2, a filament-forming protein widely distributed in extracellular matrices.
matrilin-2 is expressed in normal skin by keratinocytes and fibroblasts and may thus contribute to cutaneous homeostasis.
study of interactions by which matrilin-2 can be integrated into extracellular filamentous networks
These results suggest that matrilin-2 may be a specific and clinically useful biomarker for discriminating between indolent and clinically aggressive pilocytic astrocytoma.
DeltaNp63/BMP-7 (show BMP7 Proteins) signaling pathway modulates wound healing process through the regulation of matrilin-2.
data indicate matrilin-2 is a novel basement membrane component in the liver, synthesized during sinusoidal "capillarization" in cirrhosis & in hepatocellular carcinoma
Matn2 functions as a tumor suppressor in hepatocarcinogenesis, and in this process activation of EGFR together with that of Erk1/2, as well as inactivation of GSK-3beta, play strategic roles.
The absence of matrilin-2 has no effect on hepatic stellate cell activation and regression kinetics, synthetic activity, proliferative capacity, motility, or HSC (show FUT1 Proteins) apoptosis.
MATN2 is a deleterious endogenous neuroaxonal injury response signal that activates innate immune cells.
Matrilin-2 may play an important role in the communication of matrix to matrix and matrix to cells and will be used as a potential biomarker in the early stage of osteoarthritis of articular cartilage.
Expression of matrilin-2 during maturation of mouse skeletal tissues
Matrilin-2 null mice show no gross abnormalities during embryonic or adult development, are fertile, and have a normal lifespan.
matrilin 2 is a permissive substrate for axonal growth and cell migration, and that it is required for successful nerve regeneration.
This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.