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Matrix Metallopeptidase 13 (Collagenase 3) Proteins (MMP13)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping Matrix Metallopeptidase 13 (Collagenase 3) Antibodies (263) and Matrix Metallopeptidase 13 (Collagenase 3) Kits (111) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MMP13 17386 P33435
MMP13 171052  
MMP13 4322 P45452
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Top Matrix Metallopeptidase 13 (Collagenase 3) Proteins at antibodies-online.com

Showing 10 out of 43 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
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HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$827.20
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$855.80
Details
HOST_Escherichia coli (E. coli) Rabbit His tag 100 μg Log in to see 11 to 13 Days
$908.60
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HOST_Sf-9 cells Human Un-conjugated 10 μg Log in to see 2 to 3 Days
$388.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

MMP13 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus) ,

Human , ,
, ,

More Proteins for Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaction Partners

Zebrafish Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

  1. MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 (show MMP9 Proteins) and Mmp13.

  2. Zebra fish embryogenesis requires MMP-13 and dexamethasone and hydrocortisone modulate the expression of this gene, leading to increased activity and potentially contributing to subsequent dysmorphogenesis.

  3. JNK (show MAPK8 Proteins)-Mmp13 signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo

Xenopus laevis Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

  1. XCL3 and XCL4 can be differentially induced by prolactin (show PRL Proteins) and thyroid hormone (show PTH Proteins)(3)

Mouse (Murine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

  1. Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1 (show MMP1 Proteins)/protease-activated receptor-1 (show F2R Proteins) axis may play a role in neurogenesis following physiological and/or pathological stimuli.

  2. IL-1Ra (show IL1RN Proteins) is associated with MMP-13 expression and has a novel function in such regulation without interference of the IL-1 (show IL1A Proteins) signaling cascade.

  3. We reveal a novel role of AP-2epsilon in the regulation of gene expression in articular chondrocytes, as well as in osteoarthritis development, through modulation of Mmp13 expression and activity.

  4. B-16 melanoma cells with up-regulated MMP-13 expression promoted invasion of tumor cells through Matrigel compared with control cells transfected with empty vector. Knocked-down MMP-13 exp (show LAMC2 Proteins)ression also decreased invading cell numbers.

  5. MMP-12 (show MMP12 Proteins) and MMP-13 alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.

  6. Data indicate that tamoxifen decreased collage type II COL2A1 (show COL2A1 Proteins) by activating matrix metallopeptidases MMP-2 (show MMP2 Proteins)/13 expression.

  7. This study demonstrates that stromal as well as tumor derived MMP13 contribute to tumor cell extravasation and establishment of metastases in the liver microenvironment.

  8. Elevated MMP13 activity may contribute to Pseudomonas aeruginosa keratitis through basement membrane degradation.

  9. Mmp13 gene is regulated via at least three specific distal enhancers that display independent activities yet are able to integrate response from multiple signaling pathways in a model of activation and suppression.

  10. Interferon (show IFNA Proteins) alpha2b (show ADRA2B Proteins) may exert anti-fibrotic effect by elevating the level of matrix metalloproteinase-13 and interleukin-10 (show IL10 Proteins) in Kupffer cells, in a mitogen-activated protein kinase (show MAPK1 Proteins) signaling pathways-dependent manner.

Human Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

  1. GP73 (show GOLM1 Proteins) enhances MMP-13 expression through cAMP responsive element binding protein (CREB (show CREB1 Proteins))-mediated transcription activation. Levels of GP73 (show GOLM1 Proteins) and MMP-13 are increased and positively correlated in human HCC (show FAM126A Proteins) tissues. Augmented MMP-13 potentiates HCC (show FAM126A Proteins) cell metastasis.

  2. SENP2 (show SUMO1 Proteins) inhibits MMP13 expression in BC cells through de-SUMOylation of TBL1 (show TBL1X Proteins)/TBLR1 (show TBL1XR1 Proteins), which inhibits nuclear translocation of beta-catenin (show CTNNB1 Proteins).

  3. Hyaluronic acid exhibits a pronounced suppressive effect on MMP-13 expression in osteoarthritis.

  4. Data show that blocking the interleukin-8 (IL-8 (show IL8 Proteins))/androgen receptor (AR (show AR Proteins))/matrix metalloproteinases (MMPs) signals partially reversed the infiltrating B cells capacity to increase the bladder cancer (BCa (show BLNK Proteins)) cell invasion.

  5. Elevated levels of MMP-13 may play a role in the pathogenesis of chronic periodontitis. There is a direct correlation of increased expression of MMP-13 with various clinical and histologic parameters in disease severity

  6. Data show that the expression of transforming growth factor beta 1 (TGFB1 (show TGFB1 Proteins)) was correlated with the expression of SMA- and MAD-related protein 3 (SMAD3 (show SMAD3 Proteins)) and matrix metalloproteinase-13 (MMP13) in osteoarthritis (OA)-affected cartilage.

  7. IL-1Ra (show IL1RN Proteins) is associated with MMP-13 expression and has a novel function in such regulation without interference of the IL-1 (show IL1A Proteins) signaling cascade.

  8. siRNA inhibited the effect of MMP13-containing exosomes on tumor cells metastasis as well as angiogenesis

  9. RKIP (show PEBP1 Proteins) Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13

  10. together, these data demonstrate that SERPINE2 (show SERPINE2 Proteins) might prevent cartilage catabolism by inhibiting the expression of MMP-13, one of the most relevant collagenases, involved in cartilage breakdown in OA.

Horse (Equine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

  1. The DNA microarray analysis for matrix metalloproteinase (show MMP20 Proteins) (MMP)-related mRNA expression in equine superficial digital flexor tendinitis indicated that mRNA level of MMP-13 was apparently up-regulated in the tendinitis as compared to normal tendon.

Cow (Bovine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

  1. p38 (show MAPK14 Proteins) phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.

  2. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

  3. MMP-13 treatment of fresh articular cartilage results in cleaved fibromodulin (show FMOD Proteins) fragments

  4. increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 (show MMP1 Proteins) and MMP-13 (follicular apex (show APEX1 Proteins) vs. base) for the preovulatory collagenolysis required for follicle rupture

  5. involvement of p38 MAP kinase (show MAPK14 Proteins) in the hyaluronan oligosaccharide induction of MMP-13

  6. MMP-13 and collagenase have roles in chondrocyte hypertrophy induced by type II collagen (show COL2A1 Proteins)

  7. At high but naturally occurring concentrations the collagen peptide CB12-II induced an increase in the expressions of MMP-13 and cleavage of type II collagen (show COL2A1 Proteins) by collagenase in the mid zone and also in the superficial zone.

Rabbit Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

  1. chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 (show MMP3 Proteins) and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.

  2. Leptin (show LEP Proteins) can induce MMP-13 and have a synergistic induction effect on NO with TNF-alpha (show TNF Proteins) in rabbit articular chondrocytes in vitro.

Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Protein Profile

Protein Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Gene names and symbols associated with MMP13

  • matrix metalloproteinase 13a (mmp13a)
  • matrix metalloproteinase 13 (MGC68994)
  • matrix metallopeptidase 13 (collagenase 3) (MMP13)
  • matrix metallopeptidase 13 (collagenase 3) (mmp13)
  • matrix metalloproteinase 13 (LOC100136348)
  • matrix metalloproteinase 13 (mmp13)
  • collagenase 3 (MMP-13)
  • matrix metallopeptidase 13 (Mmp13)
  • matrix metalloproteinase 13 precursor (MMP-13)
  • cb1034 protein
  • Clg protein
  • CLG3 protein
  • gene A protein
  • MANDP1 protein
  • MGC108008 protein
  • MMP-13 protein
  • Mmp1 protein
  • MMP13 protein
  • xcl3 protein
  • xCol protein

Protein level used designations for MMP13

matrix metalloproteinase 13 , MMPLg , MMPLh , matrix metallopeptidase 13 (collagenase 3) , collagenase 3 , gene A , gene 11 , collagenase-3 , collagenase 3-like , Collagenase-3 , collagenase-1 , interstitial collagenase , matrix metalloproteinase-13 , MMP-13 , UMRCASE , matrix metalloproteinase 13 (collagenase 3)

GENE ID SPECIES
387293 Danio rerio
379552 Xenopus laevis
451513 Pan troglodytes
493679 Felis catus
613098 Xenopus (Silurana) tropicalis
703980 Macaca mulatta
772008 Gallus gallus
100012553 Monodelphis domestica
100136348 Salmo salar
100396943 Callithrix jacchus
100462632 Pongo abelii
100526826 Ictalurus punctatus
100552256 Anolis carolinensis
100584961 Nomascus leucogenys
397823 Xenopus laevis
17386 Mus musculus
171052 Rattus norvegicus
4322 Homo sapiens
100009711 Equus caballus
281914 Bos taurus
100008685 Oryctolagus cuniculus
398056 Xenopus laevis
395683 Gallus gallus
403763 Canis lupus familiaris
443113 Ovis aries
397346 Sus scrofa
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