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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP15 Kits (15) and MMP15 Proteins (9) and many more products for this protein.
Showing 10 out of 118 products:
Human Polyclonal MMP15 Primary Antibody for EIA, WB - ABIN358688
Jung, Römer, Keyszer, Lein, Kristiansen, Schnorr, Loening, Jung: mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue. in The Prostate 2003
Show all 5 references for ABIN358688
Human Polyclonal MMP15 Primary Antibody for FACS, IHC (p) - ABIN390139
Sato, Tanaka, Takino, Inoue, Seiki: Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization. in Genomics 1997
Show all 2 references for ABIN390139
Mouse (Murine) Monoclonal MMP15 Primary Antibody for IHC (fro), IHC (p) - ABIN1108260
Nakamura, Ueno, Yamashita, Shimada, Yamamoto, Noguchi, Fujimoto, Sato, Seiki, Okada: Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human papillary thyroid carcinomas. in Cancer research 1999
Data indicate that Snai1 (show SNAI1 Antibodies) is sufficient to promote mmp15 expression, cell transformation, and mesenchymal cell migration and invasion.
In conclusion, MT2-MMP is involved in gastric cancer invasion and metastasis and may serve as an independent prognostic factor for gastric cancer patients.
our data suggest that MT2-MMP expression positively involves in non-small cell lung cancer and might play an important role in promoting the tumor progression and intra-tumoral angiogenesis
HLA-G (show HLAG Antibodies) expression involved in tumor invasiveness or metastasis may rely on the NK cytotoxicity inhibition and induction of MMP-15 expression in ovarian cancer.
MMP-15 is up-regulated in preeclampsia, but does not cleave endoglin (show ENG Antibodies) to produce soluble endoglin (show ENG Antibodies).
MMP-15 and MMP-19 (show MMP19 Antibodies) are upregulated during colorectal tumorigenesis
Data show that MT2-MMP was a novel hypoxia-responsive gene and was upregulated by HIF-1alpha (show HIF1A Antibodies) under hypoxia.
The intensity of immunochemical staining of MT2-MMP was significantly positively correlated to the intratumoral angiogenesis of esophageal cancer tissues.
MMP2 (show MMP2 Antibodies) activity is associated with an increase in MT2-MMP expression and with lymph node metastasis.
These results indicate MT2-MMP might be involved in the cancer progression more than or equal to MT1-MMP (show MMP14 Antibodies) independently of MMP-2 (show MMP2 Antibodies) and MT1-MMP (show MMP14 Antibodies).
Data show that the MT2-MMP catalytic domain has a higher propensity than that of MT1-MMP (show MMP14 Antibodies) to initiate cleavage of the MMP-2 (show MMP2 Antibodies) prodomain in the absence of TIMP-2 (show TIMP2 Antibodies).
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily\; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted.
, MT-MMP 2
, Membrane type 2-MMP
, matrix metalloproteinase 15
, matrix metalloproteinase-15
, membrane-type matrix metalloproteinase 2
, membrane-type-2 matrix metalloproteinase
, matrix metalloproteinase 15 (membrane-inserted)