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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP16 Antibodies (132) and MMP16 Proteins (10) and many more products for this protein.
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miR-155 contributed to the up-regulation of MMP-16, and MMP-16 further degraded aggrecan and collagen type II, leading to the dehydration and degeneration of intervertebral discs
Neuronal knockdown of MT3-MMP resulted in the accumulation of NgR1 (show NEUROG1 ELISA Kits) at the cell surface and reduced the accumulation of the NgR1 (show NEUROG1 ELISA Kits) cleavage fragment in medium conditioned by cortical neurons
Study demonstrates that MT3-MMP, is expressed in mesenchymal tissues of the skeleton and in peri (show POSTN ELISA Kits)-skeletal soft connective tissue; and MT3-MMP-deficient mice display growth inhibition tied to a decreased viability of mesenchymal cells in skeletal tissues.
more severe intervertebral disc degeneration is correlated with higher matrix metallopeptidase 16
results suggest that miR (show MLXIP ELISA Kits)-145 functions as a tumor metastasis suppressor gene by down-regulating MMP16 and may be a potential target in osteosarcoma treatment
the results support a role for MMP16 in promoting invasive properties of the meningioma tumours
These results demonstrate that the MT3-MMP promoter is frequently hypermethylated in colorectal cancer and that downregulation of MT3-MMP may be important for cell migration in colorectal cancer.
MMP16 is a putative indicator of adverse melanoma prognosis.
Expression of MMP-16 in HTB9 and T24 cells increases following transforming growth factorbeta1 treatment.
E2F1 (show E2F1 ELISA Kits) acts as a transcriptional activator for MMPs and directly enhances MMP transcription by binding to E2F1 (show E2F1 ELISA Kits) binding sequences in the promoter, or indirectly activates MMPs (MMP-9 (show MMP9 ELISA Kits) and MMP-16)through enhanced Sp1 (show PSG1 ELISA Kits) and NF-kappa B (show NFKB1 ELISA Kits)
Matrix metalloproteinase 16 (MMP16) was a downstream target of miR (show MLXIP ELISA Kits)-146b-5p.
The overexpression of miR (show MLXIP ELISA Kits)-146b-5p in glioblastoma cell lines led to MMP16 mRNA silencing, MMP2 (show MMP2 ELISA Kits) inactivation, and the inhibition of tumour cell migration and invasion.
Data show that MMP16 is regulated by miR (show MLXIP ELISA Kits)-146a in spontaneously differentiated Caco-2 cells.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.
, MT-MMP 3
, Membrane type 3-MMP
, matrix metalloproteinase 16
, matrix metalloproteinase-16
, membrane-type matrix metalloproteinase 3
, membrane-type-3 matrix metalloproteinase
, Putative transmembrane protein C8orf57
, matrix metalloproteinase 16 (membrane-inserted)
, membrane type-matrix metalloproteinase