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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as art. Additionally we are shipping Matrix Metallopeptidase 17 (Membrane-inserted) Kits (11) and Matrix Metallopeptidase 17 (Membrane-inserted) Proteins (4) and many more products for this protein.
Showing 10 out of 83 products:
Human Polyclonal MMP17 Primary Antibody for EIA, IHC (p) - ABIN358690
Itoh, Kajita, Kinoh, Mori, Okada, Seiki: Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase. in The Journal of biological chemistry 1999
Show all 5 references for ABIN358690
Mmp17-mediated osteopontin cleavage regulated vascular SMC maturation via c-JNK during aorta wall development. Mmp17 proteolytic activity regulates vascular SMC phenotype in the arterial vessel wall. Its absence predisposes to thoracic aortic aneurysm.
function and expression of MT4-MMP
MT4-MMP promotes lung metastasis by disturbing the tumour vessel integrity and thereby facilitating tumour cell intravasation
MT1 (show MT1 Antibodies)-MT4-MMP chimaeras do not undergo normal trafficking and are not correctly processed to their fully active forms and, as a consequence, they are unable to activate pro-MMP-2 (show MMP2 Antibodies) at the cell surface.
The MT4-MMP is internalized by the clathrin-independent carriers/GPI (show GNPDA1 Antibodies)-enriched early endosomal compartments pathway, a mechanism that differs from that responsible for the internalization of other membrane-type MMP members.
Screening of patients with inherited thoracic aortic aneurysms and dissections identified a missense mutation (R373H) in the MMP17 gene that prevented the expression of the protease in human transfected cells.
A functional link between MT4-MMP and the growth factor receptor (show RYK Antibodies) EGFR (show EGFR Antibodies).
CAV1 (show CAV1 Antibodies) when found in lipid rafts does not allow the metalloproteinase MT4-MMP to localize into the lipid rafts, affecting its expression in the cell and probably its activity which is translated into the metastasis-associated activities of these cells.
It identifies MT4-MMP as a key intrinsic tumor cell determinant that contributes to the elaboration of a permissive microenvironment for metastatic dissemination.
The data presented here provide a new insight into the characteristics of MT4-MMP and highlight the common and distinct properties of the glycosylphosphatidylinositol-anchored membrane type-matrix metalloproteinases.
Studies suggest a model of hypoxia induced metastasis through expression of HIF-1alpha (show HIF1A Antibodies), and SLUG (show SNAI2 Antibodies) regulation of MT4-MMP transcription.
Data show that eosinophils constitutively express membrane type-4 matrix metalloproteinase (MT4-MMP), which is increased upon stimulation with tumor necrosis factor-alpha (show TNF Antibodies).
MT4-MMP and the proteoglycan (show Vcan Antibodies) form of syndecan-1 (show SDC1 Antibodies) have roles in ADAMTS-4 (show ADAMTS4 Antibodies) activation on the cell surface
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage.
, MT-MMP 4
, matrix metalloproteinase 17
, matrix metalloproteinase-17
, membrane type-4 matrix metalloproteinase
, membrane-type matrix metalloproteinase 4
, membrane-type-4 matrix metalloproteinase
, matrix metalloproteinase 17 (membrane-inserted)
, matrix metallopeptidase 17 (membrane-inserted)