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anti-Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) Antibodies

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as art. Additionally we are shipping Matrix Metallopeptidase 17 (Membrane-inserted) Kits (11) and Matrix Metallopeptidase 17 (Membrane-inserted) Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MMP17 23948 Q9R0S3
MMP17 288626  
MMP17 4326 Q9ULZ9
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Top anti-Matrix Metallopeptidase 17 (Membrane-inserted) Antibodies at antibodies-online.com

Showing 10 out of 84 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from A549 cells, treated with etoposide 25uM 1h, using MMP17 (Cleaved-Gln129) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB MMP17 Antibody (C-term)  western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the MMP17 antibody detected the MMP17 protein (arrow). MMP17 Antibody (C-term)  western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the MMP17 antibody detected the MMP17 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-MMP17 Antibody (Center) (ABIN390141) in NCI-H460 cell line lysates (35 µg/lane). MMP17(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image MMP17 antibody [N2C2], Internal detects MMP17 protein at cytosol on human gastria carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human gastria carcinoma. MMP17 antibody [N2C2], Internal , dilution: 1:1500. Scale bar = 100 μm. WB Image Sample (30 ug of whole cell lysate) A: Hela 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IHC (p), ELISA Human Small Intestine (formalin-fixed, paraffin-embedded) stained with MMP17 antibody ABIN214681 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated IHC, ELISA 0.05 mg Log in to see 2 to 3 Days
$481.25
Details

MMP17 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Matrix Metallopeptidase 17 (Membrane-inserted) Antibodies

  1. Human Polyclonal MMP17 Primary Antibody for EIA, IHC (p) - ABIN358690 : Itoh, Kajita, Kinoh, Mori, Okada, Seiki: Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 references for ABIN358690

More Antibodies against Matrix Metallopeptidase 17 (Membrane-inserted) Interaction Partners

Mouse (Murine) Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) interaction partners

  1. Mmp17-mediated osteopontin cleavage regulated vascular SMC maturation via c-JNK during aorta wall development. Mmp17 proteolytic activity regulates vascular SMC phenotype in the arterial vessel wall. Its absence predisposes to thoracic aortic aneurysm.

  2. function and expression of MT4-MMP

  3. MT4-MMP promotes lung metastasis by disturbing the tumour vessel integrity and thereby facilitating tumour cell intravasation

  4. MT1 (show MT1 Antibodies)-MT4-MMP chimaeras do not undergo normal trafficking and are not correctly processed to their fully active forms and, as a consequence, they are unable to activate pro-MMP-2 (show MMP2 Antibodies) at the cell surface.

Human Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) interaction partners

  1. The MT4-MMP is internalized by the clathrin-independent carriers/GPI (show GNPDA1 Antibodies)-enriched early endosomal compartments pathway, a mechanism that differs from that responsible for the internalization of other membrane-type MMP members.

  2. Screening of patients with inherited thoracic aortic aneurysms and dissections identified a missense mutation (R373H) in the MMP17 gene that prevented the expression of the protease in human transfected cells.

  3. A functional link between MT4-MMP and the growth factor receptor (show RYK Antibodies) EGFR (show EGFR Antibodies).

  4. CAV1 (show CAV1 Antibodies) when found in lipid rafts does not allow the metalloproteinase MT4-MMP to localize into the lipid rafts, affecting its expression in the cell and probably its activity which is translated into the metastasis-associated activities of these cells.

  5. It identifies MT4-MMP as a key intrinsic tumor cell determinant that contributes to the elaboration of a permissive microenvironment for metastatic dissemination.

  6. MT4-MMP promotes lung metastasis by disturbing the tumour vessel integrity and thereby facilitating tumour cell intravasation

  7. The data presented here provide a new insight into the characteristics of MT4-MMP and highlight the common and distinct properties of the glycosylphosphatidylinositol-anchored membrane type-matrix metalloproteinases.

  8. Studies suggest a model of hypoxia induced metastasis through expression of HIF-1alpha (show HIF1A Antibodies), and SLUG (show SNAI2 Antibodies) regulation of MT4-MMP transcription.

  9. Data show that eosinophils constitutively express membrane type-4 matrix metalloproteinase (MT4-MMP), which is increased upon stimulation with tumor necrosis factor-alpha (show TNF Antibodies).

  10. MT4-MMP and the proteoglycan (show Vcan Antibodies) form of syndecan-1 (show SDC1 Antibodies) have roles in ADAMTS-4 (show ADAMTS4 Antibodies) activation on the cell surface

Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) Antigen Profile

Protein Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage.

Gene names and symbols associated with MMP17

  • matrix metallopeptidase 17 (Mmp17) antibody
  • matrix metallopeptidase 17 (membrane-inserted) (MMP17) antibody
  • matrix metallopeptidase 17a (mmp17a) antibody
  • mmp17 antibody
  • MT4-MMP antibody
  • MT4MMP antibody
  • MTMMP4 antibody

Protein level used designations for MMP17

MMP-17 , MT-MMP 4 , matrix metalloproteinase 17 , matrix metalloproteinase-17 , membrane type-4 matrix metalloproteinase , membrane-type matrix metalloproteinase 4 , membrane-type-4 matrix metalloproteinase , MT4MMP , MTMMP4 , matrix metalloproteinase 17 (membrane-inserted) , matrix metallopeptidase 17 (membrane-inserted)

GENE ID SPECIES
23948 Mus musculus
288626 Rattus norvegicus
4326 Homo sapiens
570076 Danio rerio
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