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Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Proteins (MMP3)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Antibodies (390) and Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Kits (134) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MMP3 17392 P28862
MMP3 171045  
MMP3 4314 P08254
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Top Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Proteins at antibodies-online.com

Showing 10 out of 59 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 16 Days
$822.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_HEK-293 Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$206.55
Details
HOST_HEK-293 Mouse Un-conjugated   10 μg Log in to see 10 to 12 Days
$206.55
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 10 μg Log in to see 5 to 6 Days
$440.82
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$788.70
Details
HOST_Mammalian Cells Human His tag   50 μg Log in to see 5 Days
$522.50
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$806.30
Details

MMP3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Rat (Rattus) ,
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Human , , , ,
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Top referenced Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Proteins

  1. Mouse (Murine) MMP3 Protein expressed in HEK-293 - ABIN2666509 : Gill, Parks: Metalloproteinases and their inhibitors: regulators of wound healing. in The international journal of biochemistry & cell biology 2008 (PubMed)
    Show all 8 references for ABIN2666509

  2. Human MMP3 Protein expressed in HEK-293 - ABIN2666507 : Herath, Wang, Seneviratne, Darveau, Wang, Jin: The expression and regulation of matrix metalloproteinase-3 is critically modulated by Porphyromonas gingivalis lipopolysaccharide with heterogeneous lipid A structures in human gingival fibroblasts. in BMC microbiology 2013 (PubMed)
    Show all 7 references for ABIN2666507

  3. Human MMP3 Protein expressed in Escherichia coli (E. coli) - ABIN2002905 : Sternlicht, Lochter, Sympson, Huey, Rougier, Gray, Pinkel, Bissell, Werb: The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. in Cell 1999 (PubMed)

More Proteins for Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) Interaction Partners

Mouse (Murine) Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) interaction partners

  1. Mmp3-knockout mice maintained higher arterial oxygenation compared to wild-type mice in a model of acute lung injury.

  2. NMP4 (show ZNF384 Proteins) deficiency suppressed the arthritis-induced increase in bone resorption, expression of RANKL (show TNFSF11 Proteins) and MMP-3 mRNA.

  3. MMP-3 produced in blood vessel endothelial cells after spinal cord injury serves as an endogenous molecule for microglial activation followed by p38MAPK (show MAPK14 Proteins) activation and proNGF production

  4. genetic inactivation of MMP-3 has profound effects on the structural integrity and plasticity response of the visual cortex of adult mice

  5. study found significant increases of MMP-3 and MMP-12 (show MMP12 Proteins) mRNA levels and MMP12 (show MMP12 Proteins) zymographic activities in response to Cryptococcus neoformans infection but not C. gattii infection

  6. This study demonstrates the sequential involvement of Wnt5, MMP-3, DMP-1 expression, and DMP-1 degradation products by MMP-3, in effecting IL-1beta-induced proliferation of ESC-derived odontoblast-like cells.

  7. Study suggests that MMP-3 modulates intracellular MAP kinase (show MAPK1 Proteins) signaling pathway and as such, influences a molecular chaperone (show HSP90AA1 Proteins) that regulates cytoskeletal components important for neurite outgrowth, neuronal migration and dendritic arborization

  8. Data indicate that interferon regulatory factor-8 (IRF8 (show IRF8 Proteins)) regulates tumor behavior in an matrix metalloproteinase 3 (MMP3)-dependent manner.

  9. Established are novel molecular mechanisms underlying oxidative stress-mediated dopaminergic neuronal death in which MMP3 activation is a key upstream event that leads to Nox1 (show NOX1 Proteins) induction and eventual dopaminergic neuronal death.

  10. Our findings suggest that increased numbers of CD11c (show ITGAX Proteins)(+) macrophages and elevated levels of TNF-alpha (show TNF Proteins) and MMP-3 in AT and ST may explain the relationship between hyperlipidaemia and OA.

Human Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) interaction partners

  1. infiltrative pulmonary tuberculosis is characterized by impairements in the system MMP/inhibitors: the levels of MMP-1 (show MMP1 Proteins), -9 increased, MMP-3, -8, TIMP-1 (show TIMP1 Proteins) remained at the reference values and a 2-macroglobulin was low.

  2. 5A/6A polymorphism of matrix metalloproteinase-3 may contribute to recurrent atherosclerotic ischemic stroke in Chinese.

  3. We concluded that overexpression of MMP-3 and uPA (show PRAP1 Proteins), altogether with diminished expression of PAI-1 (show SERPINE1 Proteins) from metastatic tumors, might be a crucial step towards metastasis in ductal breast cancer.

  4. Study suggests no association between MMP polymorphisms and systemic sclerosis susceptibility; although, genotypes from MMP1 (show MMP1 Proteins) -1607 1G/2G and MMP3 -1171 5A/6A polymorphisms were associated with specific clinical features of the disease.

  5. A hospital-based case-control study was conducted in 230 patients with cervical cancer and 230 healthy controls to investigate the possible association between the MMP2 (show MMP2 Proteins) rs243865, MMP3 rs3025058, MMP7 (show MMP7 Proteins) rs11568818, and MMP9 (show MMP9 Proteins) rs3918242 polymorphisms, respectively, and the risk of cervical cancer

  6. NFAT1 (show NFAT1 Proteins) silencing could suppress cell migration and invasion through MMP-3.

  7. Specific gene polymorphisms are known to be associated with a different arterial physiology in the younger generation. The present study found that young Russians with the matrix metalloproteinase 3 6A/6A and gamma-glutamyltransferase 1AA genotypes have lower levels of the cardio-ankle vascular index - a recent measure of arterial stiffness.

  8. MMP-3 -11715A/6A polymorphism was associated with MMP-3 expression in herniated disc tissues. MMP-3 expression and the histological and radiological scores were positively correlated.

  9. Downregulation of RHOC (show RHOC Proteins) inhibited cholangiocellular carcinoma cells invasion and migration partially via inhibition of matrix metalloproteinase 2 (show MMP2 Proteins), 3 and 9 expression. RHOC (show RHOC Proteins) also modulated the expression of several epithelial-mesenchymal transition (EMT (show ITK Proteins))-associated proteins

  10. Based on our meta-analysis, MMP-9 (show MMP9 Proteins) rs3918242 T is correlated with susceptibility to COPD (show ARCN1 Proteins), but MMP-1 (show MMP1 Proteins) rs1799750 2G and MMP-3 rs3025058 5A are not. These results should be further confirmed using a larger sample size

Pig (Porcine) Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) interaction partners

  1. The present study was aimed to determine the association between metalloproteinase 3 (MMP3), transforming growth factor beta 1 (TGFbeta1 (show TGFB1 Proteins)) and collagen type X alpha I (COL10A1 (show COL10A1 Proteins)) gene polymorphisms with traits related to leg weakness in pigs.

  2. the identification of MMP1 (show MMP1 Proteins) and MMP10 (show MMP10 Proteins) genes in swine is reported.

  3. contribution of MMPs to the inflammatory breakdown of the blood-CSF (show CSF2 Proteins) barrier in vitro

  4. Results indicate that leukemia inhibitory factor (LIF (show LIF Proteins)) and Oncostatin M (show OSM Proteins) increase the expression of MMP-1 (show MMP1 Proteins), MMP-3, and TIMP-1 (show TIMP1 Proteins) several fold, and that their expression is reduced to basal levels in the presence of the LIF (show LIF Proteins) antagonist MH35-BD.

Rabbit Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) interaction partners

  1. Compromised autophagy may be related to the osteoarthritis progression; JNK (show MAPK8 Proteins) and p38 (show MAPK14 Proteins) MAPKs up-regulate MMP3 and down-regulate autophagy.

  2. chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.

  3. Ulinastatin (show AMBP Proteins) effectively inhibited the increased expression of MMP-2 (show MMP2 Proteins), MMP-3, and iNOS (show NOS2 Proteins) in degenerated NP cells induced by IL-1beta (show IL1B Proteins) in vitro.

  4. Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma (show PPARG Proteins) in atherosclerotic rabbits.

Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) Protein Profile

Protein Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Gene names and symbols associated with MMP3

  • matrix metallopeptidase 3 (Mmp3)
  • matrix metallopeptidase 3 (stromelysin 1, progelatinase) (MMP3)
  • matrix metallopeptidase 3 (stromelysin 1, progelatinase) (Mmp3)
  • matrix metallopeptidase 10 (stromelysin 2) (MMP10)
  • CHDS6 protein
  • MMP-3 protein
  • MMP3 protein
  • MMP10 protein
  • SL-1 protein
  • SLN-1 protein
  • SLN1 protein
  • STMY protein
  • STMY1 protein
  • STR-1 protein
  • STR1 protein

Protein level used designations for MMP3

EMS-2 , MMP-3 , SL-1 , matrix metalloproteinase 3 , matrix metalloproteinase-3 , progelatinase , stromelysin 1 , stromelysin-1 , transin-1 , PTR1 protein , matrix metalloproteinase 3 (stromelysin 1, progelatinase) , proteoglycanase , stromelysin , metalloproteinase 3 receptor , matrix metallopeptidase 3 (stromelysin 1, progelatinase) , matrix metalloproteinase 10 (stromelysin 2)

GENE ID SPECIES
17392 Mus musculus
171045 Rattus norvegicus
4314 Homo sapiens
396769 Sus scrofa
100009111 Oryctolagus cuniculus
281309 Bos taurus
403445 Canis lupus familiaris
100034195 Equus caballus
100729101 Cavia porcellus
101118895 Ovis aries
418981 Gallus gallus
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