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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Antibodies (434) and Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Kits (145) and many more products for this protein.
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Overexpression of Mmp3 in 3T3-L1 preadipocytes inhibited differentiation. High fat diet-induced obesity downregulates adipocyte MMP3 expression to trigger adipogenesis, and adipocyte TIMP4 (show TIMP4 Proteins) may modulate this process to regulate hyperplastic vs. hypertrophic adipose tissue expansion, fat distribution, and metabolic health in a sex- and depot-dependent manner.
Matrix metalloprotease (show ADAMTS7 Proteins) 3 (MMP3), an endogenous neuronal activator of microglia, increased cytokine release from YAC128 microglia compared to wildtype microglia. We found elevated MMP levels in Huntington's Disease (HD) CSF (show CSF2 Proteins), and MMP levels correlate with disease severity in HD. These data support a novel role for MMPs and microglial activation in HD pathogenesis.
These results indicate that periodic induction, via use of an eye drop, of AAV-mediated secretion of MMP-3 into aqueous humour could have therapeutic potential for those cases of glaucoma that are sub-optimally responsive to conventional pressure-reducing medications.
Data show that loss of loss of matrix metalloproteinase-3 (MMP-3) repressed the upregulation of the chemokines monocyte chemoattractant protein (MCP)-1 (show CPT1B Proteins) and (C-X-C motif) ligand 1 (CXCL1 (show CXCL1 Proteins)).
Mmp3-knockout mice maintained higher arterial oxygenation compared to wild-type mice in a model of acute lung injury.
NMP4 (show ZNF384 Proteins) deficiency suppressed the arthritis-induced increase in bone resorption, expression of RANKL (show TNFSF11 Proteins) and MMP-3 mRNA.
MMP-3 produced in blood vessel endothelial cells after spinal cord injury serves as an endogenous molecule for microglial activation followed by p38MAPK (show MAPK14 Proteins) activation and proNGF production
genetic inactivation of MMP-3 has profound effects on the structural integrity and plasticity response of the visual cortex of adult mice
study found significant increases of MMP-3 and MMP-12 (show MMP12 Proteins) mRNA levels and MMP12 (show MMP12 Proteins) zymographic activities in response to Cryptococcus neoformans infection but not C. gattii infection
This study demonstrates the sequential involvement of Wnt5, MMP-3, DMP-1 expression, and DMP-1 degradation products by MMP-3, in effecting IL-1beta-induced proliferation of ESC-derived odontoblast-like cells.
IL-21 (show IL17C Proteins) levels in rheumatoid arthritis synovial fluid were associated with matrix metalloproteinase (MMP)-1 (show MMP1 Proteins) and MMP-3.
The genetic polymorphism of MMP-1 and MMP-3 is associated with rotator cuff tear. Individuals with haplotype 2G/5A were more susceptible to rotator cuff tears in the population studied.
Taken together with our previous findings, we have replicated our results from the rodent system in a novel human system. We have revealed a unique sequential cascade involving Atg10 (show ATG10 Proteins), Wnt5a (show WNT5A Proteins), alpha1 integrin (show ITGA1 Proteins), and matrix metalloproteinase-3 in GS/BMP-4 (show BMP4 Proteins)-induced differentiation of hiPS cells into odontoblast-like cells at a relatively early stage.
These observations suggest a crucial role for cancer-associated fibroblasts and fibroblast growth factor-1 (show FGF1 Proteins)/fibroblast growth factor receptor 4 (show FGFR4 Proteins) signaling in the progression of ovarian cancer. the expression level of Snail1 (show SNAI1 Proteins) and MMP3 was reduced, while the expression level of E-cadherin (show CDH1 Proteins) increased
MMP3 overexpression is associated with Melanoma Tumor Growth and Metastasis.
Matrix metalloprotease (MMP) regulation was the top pathway involved in gingival aging. MMP3, MMP9 (show MMP9 Proteins), MMP12 (show MMP12 Proteins), and MMP13 (show MMP13 Proteins) were upregulated in old gingival tissues, concomitantly with interleukin-1 beta (IL1B (show IL1B Proteins)) expression.
Three previously investigated MMP3 variants (rs679620, rs591058 and rs650108) in addition to the functional promoter variant (rs3025058) were genotyped in 195 Australian control participants and 79 Australian individuals with chronic Achilles tendinopathy.
MMP-3 expression is deregulated in osteosarcomas and this potentially contributes to metastasis and might be a promising marker for the prognosis and therapy of metastatic osteosarcoma.
the overexpression of HMGB1 (show HMGB1 Proteins) A-box significantly decreased the IL-1beta (show IL1B Proteins)-stimulated the production of MMP-1 (show MMP1 Proteins), MMP-3 and MMP-9 (show MMP9 Proteins), and also reduced the elevated levels of inducible nitric oxide synthase (iNOS (show NOS2 Proteins)) and cyclooxygenase-2 (COX-2 (show PTGS2 Proteins)) associated with the inhibition of prostaglandin E2 (PGE2) and nitric oxide (NO) production in IL-1beta (show IL1B Proteins)-stimulated chondrocytes.
The present study was aimed to determine the association between metalloproteinase 3 (MMP3), transforming growth factor beta 1 (TGFbeta1 (show TGFB1 Proteins)) and collagen type X alpha I (COL10A1 (show COL10A1 Proteins)) gene polymorphisms with traits related to leg weakness in pigs.
the identification of MMP1 (show MMP1 Proteins) and MMP10 (show MMP10 Proteins) genes in swine is reported.
contribution of MMPs to the inflammatory breakdown of the blood-CSF (show CSF2 Proteins) barrier in vitro
Results indicate that leukemia inhibitory factor (LIF (show LIF Proteins)) and Oncostatin M (show OSM Proteins) increase the expression of MMP-1 (show MMP1 Proteins), MMP-3, and TIMP-1 (show TIMP1 Proteins) several fold, and that their expression is reduced to basal levels in the presence of the LIF (show LIF Proteins) antagonist MH35-BD.
Compromised autophagy may be related to the osteoarthritis progression; JNK (show MAPK8 Proteins) and p38 (show MAPK14 Proteins) MAPKs up-regulate MMP3 and down-regulate autophagy.
chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.
Ulinastatin (show AMBP Proteins) effectively inhibited the increased expression of MMP-2 (show MMP2 Proteins), MMP-3, and iNOS (show NOS2 Proteins) in degenerated NP cells induced by IL-1beta (show IL1B Proteins) in vitro.
Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma (show PPARG Proteins) in atherosclerotic rabbits.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
, matrix metalloproteinase 3
, matrix metalloproteinase-3
, stromelysin 1
, PTR1 protein
, matrix metalloproteinase 3 (stromelysin 1, progelatinase)
, metalloproteinase 3 receptor
, matrix metallopeptidase 3 (stromelysin 1, progelatinase)
, matrix metalloproteinase 10 (stromelysin 2)