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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP8 Kits (86) and MMP8 Proteins (26) and many more products for this protein.
Showing 10 out of 143 products:
Human Polyclonal MMP8 Primary Antibody for EIA, IHC (p) - ABIN358702
Van den Steen, Husson, Proost, Van Damme, Opdenakker: Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase. in Biochemical and biophysical research communications 2003
Show all 4 references for ABIN358702
Human Polyclonal MMP8 Primary Antibody for IF (p), IHC (p) - ABIN736283
Zhang, Li, Zhang, Fu, Cui: Hydrogen sulfide suppresses the expression of MMP-8, MMP-13, and TIMP-1 in left ventricles of rats with cardiac volume overload. in Acta pharmacologica Sinica 2013
Human Polyclonal MMP8 Primary Antibody for IP, IHC - ABIN223233
Ikonomidis, Jones, Barbour, Stroud, Clark, Kaplan, Zeeshan, Bavaria, Gorman, Spinale, Gorman: Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves. in The Journal of thoracic and cardiovascular surgery 2007
Human Polyclonal MMP8 Primary Antibody for IHC (p), WB - ABIN390153
Massova, Kotra, Fridman, Mobashery: Matrix metalloproteinases: structures, evolution, and diversification. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998
Fusion peptide inhibitors of MMP-8/-9 prevent endotoxic shock if administered within a strict time window.
the loss of MMP-8 likely has pleiotropic effects on innate immunity and angiogenesis that are reflected in changes in the protease web.
A previously unknown role of MMP8 in M2-macrophage polarization by cleaving fibromodulin (show FMOD Antibodies) and therefore increasing the bioavailability of TGF-beta (show TGFB1 Antibodies).
MMP-8-deficient mice had significantly lower serum triglyceride (TG) levels (P = 0.003) and larger HDL (show APOA Antibodies)particles compared with wild-type (WT (show HSD11B1 Antibodies)) mice. However, no differences were observed in the apoA-I levels.
These results demonstrate that MMP-8 critically mediates microglial activation by modulating TNF-alpha (show TNF Antibodies) activity, which may explain neuroinflammation in septic mouse brain.
MMP-13 (show MMP13 Antibodies) prevails over MMP-8 in collagen degradation in atheromata.
MMP8 enhances vascular smooth muscle cell proliferation via an ADAM10 (show ADAM10 Antibodies), N-cadherin (show CDH2 Antibodies), and beta-catenin (show CTNNB1 Antibodies)-mediated pathway and plays an important role in neointima formation.
Suggest that MMP8 plays an important role in angiogenesis in vitro and in vivo.
MMP8 plays an important role in stem cell migration and their recruitment into atherosclerotic lesions.
These results show that MMP-8 can modulate the levels of S100A8 (show S100A8 Antibodies) and S100A9 (show S100A9 Antibodies) and its absence promotes the lung inflammatory response during endotoxemia.
Suggest that MMP-8 polymorphism -799 C/T was a risk for developing chronic periapical lesions.
The reciprocal positive interplay between MMP-8 and TGF-beta1 contributes to HCC invasion and metastasis by inducing EMT mainly through the PI3K/Akt/Rac1 pathway.
increased levels in saliva (show RAG1AP1 Antibodies) and serum in women with polycystic ovary syndrome, and is potentiated in the presence of gingivitis
Positive results of the aMMP-8 test significantly correlate with generalized ChP (show CHP Antibodies). The aMMP-8 test may be used by physicians to detect periodontitis in their patients.
miR (show MLXIP Antibodies)-539 plays a key role in inhibiting osteosarcoma cell invasion and migration and can regulate MMP8 expression in osteosarcoma cells.
salivary levels of the analyzed biomarkers MMP-8, -9, MPO (show MPO Antibodies) are associated with periodontal status. However, these biomarkers could not differentiate between patients with or without a MI.
Moderate-strength STS (show STS Antibodies) causes the highest TIMP-1 (show TIMP1 Antibodies)/MMP-8 ratio, leading to appropriate conditions for reformation of the extracellular matrix
Gender-specific analysis of MMPs demonstrated consistent increase in MMP-1 (show MMP1 Antibodies) and -8 in tuberculosis, but MMP-8 was a better discriminator for TB in men.
MMP-8, MMP-9 (show MMP9 Antibodies), and YKL-40 (show CHI3L1 Antibodies) might serve as novel non-invasive biomarkers of CF lung disease and pulmonary exacerbations.
The expression of MMP-7 (show MMP7 Antibodies), -8, -9 and -13 in the gingiva of the young patients with aggressive periodontitis and type 1 diabetes mellitus was positive in all studied cases.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
matrix metallopeptidase 8 (neutrophil collagenase)
, matrix metalloproteinase 8
, collagenase 2
, matrix metalloproteinase-8
, neutrophil collagenase
, neutrophil collagenease
, PMNL collagenase
, matrix metalloproteinase 8 (neutrophil collagenase)