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The protein encoded by MDC1 contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence.
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Human Polyclonal MDC1 Primary Antibody for ICC, IF - ABIN151859
Shi, Ma, Willers, Akhtar, Scott, Zhang, Powell, Zhang: Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation. in The Journal of biological chemistry 2008
Show all 16 references for ABIN151859
Chimpanzee Monoclonal MDC1 Primary Antibody for ICC, IF - ABIN863114
Lou, Chen, Asaithamby, Minter-Dykhouse, Chen, Chen: MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. in The Journal of biological chemistry 2004
Show all 4 references for ABIN863114
Human Polyclonal MDC1 Primary Antibody for IHC, ELISA - ABIN1532151
Shiina, Ota, Shimizu, Katsuyama, Hashimoto, Takasu, Anzai, Kulski, Kikkawa, Naruse, Kimura, Yanagiya, Watanabe, Hosomichi, Kohara, Iwamoto, Umehara, Meyer, Wanner, Sano, Macquin, Ikeo, Tokunaga et al.: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. ... in Genetics 2006
Show all 2 references for ABIN1532151
Human Polyclonal MDC1 Primary Antibody for ICC, IF - ABIN4333285
Mastrocola, Kim, Trinh, Rodenkirch, Tibbetts: The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage. in The Journal of biological chemistry 2013
MDC1 silencing enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in xenograft tumor growth inhibition.
oligomerization of MDC1 plays an important role in DDR (show DDR1 Antibodies) and help understand the formation of proteins complexes at the sites of DNA damage.
structural insight into MDC1-CHK2 (show CHEK2 Antibodies) interaction
the DNA damage response pathway centered on MDC1 triggers epigenetic silencing of sex chromosomes in germ cells
Data show that loss of Mof (show KAT8 Antibodies) leads to reduction of histone H4 (show HIST1H4H Antibodies) K16 (show KRT16 Antibodies) acetylation, cell cycle arrest, chromosome aberration, defects in DNA damage repair, and complete loss of Mdc1 response to DNA damage.
Data show that ATM (show ATM Antibodies)-dependent resection at a subset of DSBs leads to ATR (show ATR Antibodies)-dependent Chk1 (show CHEK1 Antibodies) activation, and that 53BP1 (show TP53BP1 Antibodies)(-/-) and MDC1(-/-) cells manifest a checkpoint defect at high radiation doses.
identification and description of a functional homologue of human MDC1/ NFBD1; in response to ionizing radiation it forms foci that co-localize with the MRE11 (show MRE11A Antibodies)-RAD50 (show RAD50 Antibodies)-NBS1 (show NBN Antibodies) (MRN) complex and factors such as gammaH2AX (show H2AFX Antibodies) and 53BP1 (show TP53BP1 Antibodies)
MDC1, as a signal amplifier of the ATM (show ATM Antibodies) pathway, is vital in controlling proper DNA damage response and maintaining genomic stability.
MDC1 knockdown affected the formation of telomere dysfunction-induced foci.
Dephosphorylation of TN-associated histone gammaH2AX (show H2AFX Antibodies) chromatin suggests annealing of single strands or repair of double-strand breaks DSBs
NFBD1 knockdown improves the chemosensitivity of NPC (show NPC1 Antibodies) cells by inhibiting cell growth and promoting apoptosis through the impairment of DNA damage repair, suggesting NFBD1 as a novel therapeutic target for NPC (show NPC1 Antibodies).
knockdown of MCM2 or MCM6 could significantly inhibit foci forming of MDC1 in TE-1 nuclei in response to bleomycin-induced DNA damage (p < 0.001). This study indicates the direct interaction between MDC1 and MCMs in TE-1 nuclei.
The interaction of MDC1 with RNF8 (show RNF8 Antibodies), but not with ATM (show ATM Antibodies) requires WRAP53beta, suggesting that WRAP53beta facilitates the former interaction without altering phosphorylation of MDC1 by ATM (show ATM Antibodies).
MDC1 recruits TNKS1 (show TNKS Antibodies) and TNKS2 (show TNKS2 Antibodies) to DNA lesions.
we generated two HEP (show EPHB6 Antibodies)-2 cell lines with a stable knockdown of MDC1 or 53BP1 (show TP53BP1 Antibodies) with short hairpin RNA (shRNA), respectively, and investigated the effect of MDC1 and 53BP1 (show TP53BP1 Antibodies) on cell radiosensitivity
During replicative senescence and stress-induced premature senescence, MDC1 is downregulated by upregulating miR (show MLXIP Antibodies)-22.
we have identified a novel antisense lncRNA MDC1-AS, which may participate in bladder cancer through up-regulation of its antisense tumor-suppressing gene MDC1
our findings suggest that MDC1 promotes ovarian cancer metastasis through the induction of EMT (show ITK Antibodies).
The study suggest that MDC1 as an epigenetic modifier regulates androgen receptor (show AR Antibodies) transcriptional activity and MDC1 may function as a tumor suppressor of prostate cancer.
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
mediation of DNA damage checkpoint 1
, mediator of DNA damage checkpoint protein 1
, homologue to Drosophila photoreceptor protein calphotin
, mediator of DNA damage checkpoint 1
, nuclear factor with BRCT domains 1