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anti-Mdc1 (MDC1) Antibodies

The protein encoded by MDC1 contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. Additionally we are shipping MDC1 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MDC1 240087 Q5PSV9
MDC1 309595 Q5U2M8
MDC1 9656 Q14676
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Top anti-MDC1 Antibodies at antibodies-online.com

Showing 10 out of 108 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain, using ... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-MDC1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1... WB Suggested Anti-MDC1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chimpanzee Mouse Un-conjugated ICC, IF, WB   100 μg Log in to see 3 to 4 Days
$360.80
Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded 59T xeno... WB Image Sample (30 ug of whole cell lysate) A: HeLa nucleus 5% SDS PA... 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), WB 100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated WB 200 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4... Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit ... 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated ELISA   100 μg Log in to see 2 to 3 Days
$369.00
Details
Human Rabbit Un-conjugated IHC, ELISA 100 μg Log in to see 11 to 16 Days
$412.86
Details

MDC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , , , ,
,
Rat (Rattus) , , ,

Human , , , ,
, ,

Top referenced anti-MDC1 Antibodies

  1. Chimpanzee Monoclonal MDC1 Primary Antibody for ICC, IF - ABIN863114 : Lou, Chen, Asaithamby, Minter-Dykhouse, Chen, Chen: MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. in The Journal of biological chemistry 2004 (PubMed)
    Show all 4 references for ABIN863114

  2. Human Polyclonal MDC1 Primary Antibody for IHC, ELISA - ABIN1532151 : Shiina, Ota, Shimizu, Katsuyama, Hashimoto, Takasu, Anzai, Kulski, Kikkawa, Naruse, Kimura, Yanagiya, Watanabe, Hosomichi, Kohara, Iwamoto, Umehara, Meyer, Wanner, Sano, Macquin, Ikeo, Tokunaga et al.: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. ... in Genetics 2006 (PubMed)
    Show all 2 references for ABIN1532151

More Antibodies against MDC1 Interaction Partners

Mouse (Murine) Mdc1 (MDC1) interaction partners

  1. MDC1 silencing enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in xenograft tumor growth inhibition.

  2. oligomerization of MDC1 plays an important role in DDR (show DDR1 Antibodies) and help understand the formation of proteins complexes at the sites of DNA damage.

  3. structural insight into MDC1-CHK2 (show CHEK2 Antibodies) interaction

  4. the DNA damage response pathway centered on MDC1 triggers epigenetic silencing of sex chromosomes in germ cells

  5. Data show that loss of Mof (show KAT8 Antibodies) leads to reduction of histone H4 (show HIST1H4H Antibodies) K16 (show KRT16 Antibodies) acetylation, cell cycle arrest, chromosome aberration, defects in DNA damage repair, and complete loss of Mdc1 response to DNA damage.

  6. Data show that ATM (show ATM Antibodies)-dependent resection at a subset of DSBs leads to ATR (show ATR Antibodies)-dependent Chk1 (show CHEK1 Antibodies) activation, and that 53BP1 (show TP53BP1 Antibodies)(-/-) and MDC1(-/-) cells manifest a checkpoint defect at high radiation doses.

  7. identification and description of a functional homologue of human MDC1/ NFBD1; in response to ionizing radiation it forms foci that co-localize with the MRE11 (show MRE11A Antibodies)-RAD50 (show RAD50 Antibodies)-NBS1 (show NBN Antibodies) (MRN) complex and factors such as gammaH2AX (show H2AFX Antibodies) and 53BP1 (show TP53BP1 Antibodies)

  8. MDC1, as a signal amplifier of the ATM (show ATM Antibodies) pathway, is vital in controlling proper DNA damage response and maintaining genomic stability.

  9. MDC1 knockdown affected the formation of telomere dysfunction-induced foci.

  10. Dephosphorylation of TN-associated histone gammaH2AX (show H2AFX Antibodies) chromatin suggests annealing of single strands or repair of double-strand breaks DSBs

Human Mdc1 (MDC1) interaction partners

  1. MDC1 recruits TNKS1 (show TNKS Antibodies) and TNKS2 (show TNKS2 Antibodies) to DNA lesions.

  2. MDC1 silencing enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in xenograft tumor growth inhibition.

  3. we generated two HEP (show EPHB6 Antibodies)-2 cell lines with a stable knockdown of MDC1 or 53BP1 (show TP53BP1 Antibodies) with short hairpin RNA (shRNA), respectively, and investigated the effect of MDC1 and 53BP1 (show TP53BP1 Antibodies) on cell radiosensitivity

  4. During replicative senescence and stress-induced premature senescence, MDC1 is downregulated by upregulating miR (show MLXIP Antibodies)-22.

  5. we have identified a novel antisense lncRNA MDC1-AS, which may participate in bladder cancer through up-regulation of its antisense tumor-suppressing gene MDC1

  6. our findings suggest that MDC1 promotes ovarian cancer metastasis through the induction of EMT (show ITK Antibodies).

  7. The study suggest that MDC1 as an epigenetic modifier regulates androgen receptor (show AR Antibodies) transcriptional activity and MDC1 may function as a tumor suppressor of prostate cancer.

  8. data suggested that the SNP rs4713354A>C of MDC1 may be a functional genetic biomarker for susceptibility to lung cancer in Chinese

  9. NFBD1/MDC1 is phosphorylated by PLK1 (show PLK1 Antibodies) and controls G2/M transition through the regulation of a TOPOIIalpha-mediated decatenation checkpoint.

  10. ATM (show ATM Antibodies) and MDC1 maintain genomic stability not only by controlling the DNA damage response, but also by regulating spindle assembly checkpoint activation, providing an important link between these two essential biological processes.

MDC1 Antigen Profile

Protein Summary

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

Gene names and symbols associated with anti-Mdc1 (MDC1) Antibodies

  • mediator of DNA damage checkpoint 1 (Mdc1) antibody
  • mediator of DNA-damage checkpoint 1 (MDC1) antibody
  • 6820401C03 antibody
  • AA413496 antibody
  • mKIAA0170 antibody
  • NFBD1 antibody

Protein level used designations for anti-Mdc1 (MDC1) Antibodies

mediation of DNA damage checkpoint 1 , mediator of DNA damage checkpoint protein 1 , homologue to Drosophila photoreceptor protein calphotin , mediator of DNA damage checkpoint 1 , nuclear factor with BRCT domains 1

GENE ID SPECIES
240087 Mus musculus
309595 Rattus norvegicus
9656 Homo sapiens
474829 Canis lupus familiaris
100144453 Sus scrofa
511168 Bos taurus
471959 Pan troglodytes
Selected quality suppliers for anti-MDC1 (MDC1) Antibodies
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