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Mdc1 (MDC1) ELISA Kits

The protein encoded by MDC1 contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. Additionally we are shipping MDC1 Antibodies (108) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
MDC1 240087 Q5PSV9
MDC1 309595 Q5U2M8
MDC1 9656 Q14676
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Top MDC1 ELISA Kits at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human
96 Tests Log in to see 16 to 21 Days
$999.43
Details
Mouse
96 Tests Log in to see 16 to 21 Days
$999.43
Details
Rat
96 Tests Log in to see 16 to 21 Days
$999.43
Details

More ELISA Kits for MDC1 Interaction Partners

Mouse (Murine) Mdc1 (MDC1) interaction partners

  1. MDC1 silencing enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in xenograft tumor growth inhibition.

  2. oligomerization of MDC1 plays an important role in DDR (show DDR1 ELISA Kits) and help understand the formation of proteins complexes at the sites of DNA damage.

  3. structural insight into MDC1-CHK2 (show CHEK2 ELISA Kits) interaction

  4. the DNA damage response pathway centered on MDC1 triggers epigenetic silencing of sex chromosomes in germ cells

  5. Data show that loss of Mof (show KAT8 ELISA Kits) leads to reduction of histone H4 K16 (show KRT16 ELISA Kits) acetylation, cell cycle arrest, chromosome aberration, defects in DNA damage repair, and complete loss of Mdc1 response to DNA damage.

  6. Data show that ATM (show ATM ELISA Kits)-dependent resection at a subset of DSBs leads to ATR (show ATR ELISA Kits)-dependent Chk1 (show CHEK1 ELISA Kits) activation, and that 53BP1 (show TP53BP1 ELISA Kits)(-/-) and MDC1(-/-) cells manifest a checkpoint defect at high radiation doses.

  7. identification and description of a functional homologue of human MDC1/ NFBD1; in response to ionizing radiation it forms foci that co-localize with the MRE11 (show MRE11A ELISA Kits)-RAD50 (show RAD50 ELISA Kits)-NBS1 (show NBN ELISA Kits) (MRN) complex and factors such as gammaH2AX (show H2AFX ELISA Kits) and 53BP1 (show TP53BP1 ELISA Kits)

  8. MDC1, as a signal amplifier of the ATM (show ATM ELISA Kits) pathway, is vital in controlling proper DNA damage response and maintaining genomic stability.

  9. MDC1 knockdown affected the formation of telomere dysfunction-induced foci.

  10. Dephosphorylation of TN-associated histone gammaH2AX (show H2AFX ELISA Kits) chromatin suggests annealing of single strands or repair of double-strand breaks DSBs

Human Mdc1 (MDC1) interaction partners

  1. MDC1 recruits TNKS1 (show TNKS ELISA Kits) and TNKS2 (show TNKS2 ELISA Kits) to DNA lesions.

  2. MDC1 silencing enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in xenograft tumor growth inhibition.

  3. we generated two HEP (show EPHB6 ELISA Kits)-2 cell lines with a stable knockdown of MDC1 or 53BP1 (show TP53BP1 ELISA Kits) with short hairpin RNA (shRNA), respectively, and investigated the effect of MDC1 and 53BP1 (show TP53BP1 ELISA Kits) on cell radiosensitivity

  4. During replicative senescence and stress-induced premature senescence, MDC1 is downregulated by upregulating miR (show MLXIP ELISA Kits)-22.

  5. we have identified a novel antisense lncRNA MDC1-AS, which may participate in bladder cancer through up-regulation of its antisense tumor-suppressing gene MDC1

  6. our findings suggest that MDC1 promotes ovarian cancer metastasis through the induction of EMT (show ITK ELISA Kits).

  7. The study suggest that MDC1 as an epigenetic modifier regulates androgen receptor (show AR ELISA Kits) transcriptional activity and MDC1 may function as a tumor suppressor of prostate cancer.

  8. data suggested that the SNP rs4713354A>C of MDC1 may be a functional genetic biomarker for susceptibility to lung cancer in Chinese

  9. NFBD1/MDC1 is phosphorylated by PLK1 (show PLK1 ELISA Kits) and controls G2/M transition through the regulation of a TOPOIIalpha-mediated decatenation checkpoint.

  10. ATM (show ATM ELISA Kits) and MDC1 maintain genomic stability not only by controlling the DNA damage response, but also by regulating spindle assembly checkpoint activation, providing an important link between these two essential biological processes.

MDC1 Antigen Profile

Antigen Summary

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

Gene names and symbols associated with Mdc1 (MDC1) ELISA Kits

  • mediator of DNA damage checkpoint 1 (Mdc1) antibody
  • mediator of DNA-damage checkpoint 1 (MDC1) antibody
  • 6820401C03 antibody
  • AA413496 antibody
  • mKIAA0170 antibody
  • NFBD1 antibody

Protein level used designations for Mdc1 (MDC1) ELISA Kits

mediation of DNA damage checkpoint 1 , mediator of DNA damage checkpoint protein 1 , homologue to Drosophila photoreceptor protein calphotin , mediator of DNA damage checkpoint 1 , nuclear factor with BRCT domains 1

GENE ID SPECIES
240087 Mus musculus
309595 Rattus norvegicus
9656 Homo sapiens
474829 Canis lupus familiaris
100144453 Sus scrofa
511168 Bos taurus
471959 Pan troglodytes
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