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The protein encoded by MDC1 contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. Additionally we are shipping MDC1 Antibodies (164) and many more products for this protein.
MDC1 plays a fundamentally significant role in maintenance of genomic stability through a DNA damage response-independent pathway.
MDC1 silencing enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in xenograft tumor growth inhibition.
oligomerization of MDC1 plays an important role in DDR (show DDR1 ELISA Kits) and help understand the formation of proteins complexes at the sites of DNA damage.
structural insight into MDC1-CHK2 (show CHEK2 ELISA Kits) interaction
the DNA damage response pathway centered on MDC1 triggers epigenetic silencing of sex chromosomes in germ cells
Data show that loss of Mof (show KAT8 ELISA Kits) leads to reduction of histone H4 K16 (show KRT16 ELISA Kits) acetylation, cell cycle arrest, chromosome aberration, defects in DNA damage repair, and complete loss of Mdc1 response to DNA damage.
Data show that ATM (show ATM ELISA Kits)-dependent resection at a subset of DSBs leads to ATR (show ATR ELISA Kits)-dependent Chk1 (show CHEK1 ELISA Kits) activation, and that 53BP1 (show TP53BP1 ELISA Kits)(-/-) and MDC1(-/-) cells manifest a checkpoint defect at high radiation doses.
identification and description of a functional homologue of human MDC1/ NFBD1; in response to ionizing radiation it forms foci that co-localize with the MRE11 (show MRE11A ELISA Kits)-RAD50 (show RAD50 ELISA Kits)-NBS1 (show NBN ELISA Kits) (MRN) complex and factors such as gammaH2AX (show H2AFX ELISA Kits) and 53BP1 (show TP53BP1 ELISA Kits)
MDC1, as a signal amplifier of the ATM (show ATM ELISA Kits) pathway, is vital in controlling proper DNA damage response and maintaining genomic stability.
MDC1 knockdown affected the formation of telomere dysfunction-induced foci.
ASF1a (show ASF1A ELISA Kits) promotes non-homologous end joining repair by facilitating phosphorylation of MDC1 by ATM (show ATM ELISA Kits) at double-strand breaks.
the opposing activities of RNF4 (show RNF4 ELISA Kits) and ataxin-3 (show ATXN3 ELISA Kits) consolidate robust MDC1-dependent signaling and repair ofDNA double-strand break.
NFBD1 protein is overexpressed in NPC (show NPC1 ELISA Kits) tissues and that silencing NFBD1 can inhibit cell growth, induce apoptosis, increase the production of intracellular ROS (show ROS1 ELISA Kits). NFBD1 knockdown also inhibits the tumorigenicity of NPC (show NPC1 ELISA Kits) cells in vivo.
NFBD1 knockdown improves the chemosensitivity of NPC (show NPC1 ELISA Kits) cells by inhibiting cell growth and promoting apoptosis through the impairment of DNA damage repair, suggesting NFBD1 as a novel therapeutic target for NPC (show NPC1 ELISA Kits).
knockdown of MCM2 or MCM6 could significantly inhibit foci forming of MDC1 in TE-1 nuclei in response to bleomycin-induced DNA damage (p < 0.001). This study indicates the direct interaction between MDC1 and MCMs in TE-1 nuclei.
The interaction of MDC1 with RNF8 (show RNF8 ELISA Kits), but not with ATM (show ATM ELISA Kits) requires WRAP53beta, suggesting that WRAP53beta facilitates the former interaction without altering phosphorylation of MDC1 by ATM (show ATM ELISA Kits).
MDC1 recruits TNKS1 (show TNKS ELISA Kits) and TNKS2 (show TNKS2 ELISA Kits) to DNA lesions.
we generated two HEP (show EPHB6 ELISA Kits)-2 cell lines with a stable knockdown of MDC1 or 53BP1 (show TP53BP1 ELISA Kits) with short hairpin RNA (shRNA), respectively, and investigated the effect of MDC1 and 53BP1 (show TP53BP1 ELISA Kits) on cell radiosensitivity
During replicative senescence and stress-induced premature senescence, MDC1 is downregulated by upregulating miR (show MLXIP ELISA Kits)-22.
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
mediation of DNA damage checkpoint 1
, mediator of DNA damage checkpoint protein 1
, homologue to Drosophila photoreceptor protein calphotin
, mediator of DNA damage checkpoint 1
, nuclear factor with BRCT domains 1