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anti-Mediator Complex Subunit 12 (MED12) Antibodies

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. Additionally we are shipping MED12 Kits (19) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MED12 9968 Q93074
MED12 679693  
MED12 59024 A2AGH6
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Top anti-MED12 Antibodies at antibodies-online.com

Showing 10 out of 35 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (38.54 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using MED12 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of TRAP230 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of TRAP230 expression in HEK293T (A), NS-1 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$419.83
Details
Human Rabbit Un-conjugated IHC, ELISA 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated ELISA, IHC   100 μL Log in to see 14 Days
$201.19
Details
Human Rabbit Un-conjugated ELISA   100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated ELISA, WB   50 μL Log in to see 9 to 11 Days
$313.50
Details
Human Rabbit Un-conjugated IHC   100 μL Log in to see 8 to 10 Days
$375.83
Details
Human Goat Biotin ELISA, WB   100 μL Log in to see 16 Days
$620.71
Details

MED12 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,
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Rat (Rattus) ,
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Mouse (Murine) ,
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Top referenced anti-MED12 Antibodies

  1. Human Polyclonal MED12 Primary Antibody for ELISA, WB - ABIN564287 : Rienzo, Casamassimi, Schiano, Grimaldi, Infante, Napoli: Distinct alternative splicing patterns of mediator subunit genes during endothelial progenitor cell differentiation. in Biochimie 2012 (PubMed)

More Antibodies against MED12 Interaction Partners

Human Mediator Complex Subunit 12 (MED12) interaction partners

  1. MED12 gene mutation is associated with Lujan-Fryns syndrome.

  2. Missense mutation in the MED12 gene is associated with hypertonia, eosinophilic esophagitis, penile chordee, and particular facial dysmorphisms beyond Ohdo syndrome.

  3. In conclusion, the authors demonstrated the restriction of MED12 exon 2 mutation to phyllodes tumours (73.6%, 39/53) and its absence in other spindle neoplasms of the breast.

  4. our results suggest that the majority of malignant breast phyllodes tumours may be driven by genetic/epigenetic alterations other than MED12 exon 2 somatic mutations

  5. Data suggest that MED13 (show MED13 Antibodies), MED12, CDK8 (show CDK8 Antibodies) and cyclin C (CycC (show CCNC Antibodies)) comprise a four-subunit "kinase" module of the Mediator complex that functions as a major ingress of oncogenic and developmental signaling/gene expression in humans. [REVIEW]

  6. Frequent MED12 mutations in uterine leiomyosarcomas

  7. Specific somatic MED12 mutations in prostate cancer and uterine leiomyomas accumulate in two separate regions of the gene and promote tumorigenesis through clearly distinct mechanisms.

  8. This revealed four patients to have two or more tumors that were clonally related, all of which lacked MED12 mutations. DEPDC5 was discovered as a novel tumor suppressor gene playing a role in the progression of uterine leiomyomas.

  9. Frequent mutations in MED12 exon 2 in the phyllodes tumors suggest that it may share genetic etiology with uterine leiomyoma, a subgroup of uterine leiomyosarcomas and breast fibroadenoma.

  10. the MED12 mutation is implicated in the pathogenesis of both FA and PT and that a certain percentage of FAs (show FAS Antibodies) with MED12 mutation may progress to PTs (show PTS Antibodies).

Zebrafish Mediator Complex Subunit 12 (MED12) interaction partners

  1. med12 mutants exhibit multiple defects in the development of the epithalamus, including failure of parapineal specification and disruption of cell differentiation and/or maintenance of specific cell types in the pineal organ and the habenula.

  2. The kto/med12 mutation results in specific defects of boundary cell formation in the zebrafish hindbrain

  3. critical targets of TRAP230 function may include proteins important for cell mobility, cell sorting, and tissue assembly

  4. A critical function of the Trap230 subunit is shown for Sox9 (show SOX9 Antibodies) as a coactivator; Trap230 also participates in Sox9 (show SOX9 Antibodies)-independent transcriptional regulation.

  5. reveal a regulatory role of motionless/Med12 in vertebrate neuronal development

  6. Med12 modulates the ability of Casanova/Sox32 to induce sox17 expression in endodermal development.

Mouse (Murine) Mediator Complex Subunit 12 (MED12) interaction partners

  1. Med1 and Med12, two subunits of the mediator complex implicated in transcription initiation and long-range enhancer/promoter loop formation, are dynamically recruited to the IgH locus enhancers.

  2. leiomyomatous, Med12 c.131G>A variant-expressing uteri developed chromosomal rearrangements.

  3. this work points to Med12 being an essential coregulator of transcription factors controlling neural tube closure.

  4. show that in Med12 hypomorphic embryos, the Wnt (show WNT2 Antibodies)/planar cell polarity pathway is disrupted and that canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling is impaired.

  5. Nanog (show NANOG Antibodies) and Med12 function in concert to regulate Nanog (show NANOG Antibodies) target genes and identify a novel role for Med12 in embryonic stem cell regulation.

MED12 Antigen Profile

Protein Summary

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.

Gene names and symbols associated with MED12

  • mediator complex subunit 12 (MED12) antibody
  • mediator complex subunit 12 (Med12) antibody
  • mediator of RNA polymerase II transcription, subunit 12 homolog (med12) antibody
  • mediator of RNA polymerase II transcription, subunit 12 homolog (yeast) (Med12) antibody
  • 230kDa antibody
  • ARC240 antibody
  • CAGH45 antibody
  • FGS1 antibody
  • HOPA antibody
  • MED12S antibody
  • Mopa antibody
  • OHDOX antibody
  • OKS antibody
  • OPA-1 antibody
  • OPA1 antibody
  • Tnrc11 antibody
  • Trap230 antibody

Protein level used designations for MED12

mediator of RNA polymerase II transcription, subunit 12 homolog , CAG repeat protein 45 , OPA-containing protein , activator-recruited cofactor 240 kDa component , human opposite paired , mediator of RNA polymerase II transcription subunit 12 , putative mediator subunit 12 , thyroid hormone receptor-associated protein complex 230 kDa component , thyroid hormone receptor-associated protein, 230 kDa subunit , trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit) , trinucleotide repeat-containing gene 11 protein , trinucleotide repeat containing 11 , kohtalo , kto , mediator complex subunit 12 , mot_m807 , motionless , protein kohtalo , protein motionless , shiri , shr , thyroid hormone receptor-associated protein 230 , thyroid hormone receptor-associated protein complex component TRAP230 , trap230 , OPA-containing protein 1 , trinucleotide repeat containing 11 (THR-associated protein)

GENE ID SPECIES
480952 Canis lupus familiaris
9968 Homo sapiens
679693 Rattus norvegicus
449626 Pan troglodytes
566632 Danio rerio
59024 Mus musculus
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