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Mediator Complex Subunit 23 Proteins (MED23)

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. Additionally we are shipping MED23 Antibodies (47) and MED23 Kits (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MED23 9439 Q9ULK4
MED23 70208 Q80YQ2
MED23 309565  
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Top MED23 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

MED23 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Mediator Complex Subunit 23 (MED23) Interaction Partners

Human Mediator Complex Subunit 23 (MED23) interaction partners

  1. MED23-associated intellectual disability has been found in two brothers from a non-consanguineous family.

  2. MED23 plays an important role in hepatocarcinogenesis, and it may be a novel target for HCC (show FAM126A Proteins) therapy.

  3. Upregulation of mediator MED23 in non-small-cell lung cancer promotes the growth, migration, and metastasis of cancer cells.

  4. Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb (show CCNT1 Proteins).

  5. Data show that Med23 RNAi specifically inhibits the proliferation and tumorigenicity of lung cancer cells with hyperactive Ras activity.

  6. missense mutation (p. R617Q) in MED23 that cosegregates with nonsyndromic autosomal recessive intellectual disability; mutation impaired response of JUN and FOS to mitogens by altering interaction between enhancer-bound transcription factors and Mediator

  7. DRIP130 regulates HER2 (show ERBB2 Proteins) expression by binding to ESX (show ELF3 Proteins)

  8. loss of DRIP-130 expression, as a result of the gross loss of human chromosome 6q16.3-q23, provokes increased tumor metastasis

  9. Sur2(CRSP3) is required for activation by Adenovirus E1A (show BCKDHA Proteins) CR3 (show ITGAM Proteins) activation domain and is required for MAPK (show MAPK1 Proteins)-mediated activation of Elk-1 (show ELK1 Proteins).

Mouse (Murine) Mediator Complex Subunit 23 (MED23) interaction partners

  1. MED23 constitutes a molecular node in the regulatory network of anabolic bone formation and related diseases.

  2. Med23 contributes to controlling T-cell activation at the transcriptional level and prevents the development of autoimmunity.

  3. The hepatic Med23 deletion impaired the Mediator and RNAPII recruitment and attenuated the expression of FOXO1 (show FOXO1 Proteins) target genes.

  4. Data show that Kruppel-like transcription factors KLF2 (show KLF2 Proteins) expression is decreased in mediator complex Med23 null thymocytes.

  5. Mediator Med23 deficiency enhances neural differentiation of murine embryonic stem cells through modulating BMP signaling.

  6. Reduced expression of MED23 inhibits cell apoptosis by downregulation of Bax (show BAX Proteins), activated Caspase 3 (show CASP3 Proteins), activated Caspase 9 (show CASP9 Proteins) and upregulation of cyclinD1 and Bcl2 (show BCL2 Proteins).

  7. Data show tha tMed23 deficiency in fibroblasts selectively inhibited the oncogenic transformation induced by Ras.

  8. Mediator MED23 controls the cell fate preference that directs differentiation into smooth muscle cells (SMCs) or adipocytes

  9. MED23 regulates a subset of hnRNP L (show HNRNPL Proteins)-targeted alternative splicing (AS) and alternative cleavage and polyadenylation (APA (show ENPEP Proteins)) events.

  10. MED23 Mediator controls Egr1 gene and stimulates Pol II initiation at a step subsequent to preinitiation complex assembly

MED23 Protein Profile

Protein Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with MED23

  • Mediator complex subunit 23 (MED23)
  • mediator complex subunit 23 (MED23)
  • mediator complex subunit 23 (LOC100342894)
  • mediator complex subunit 23 (med23)
  • mediator of RNA polymerase II transcription subunit 23 (MED23)
  • mediator complex subunit 23 (Med23)
  • Protein SUR-2 (sur-2)
  • 130kDa protein
  • 3000002A17Rik protein
  • ARC130 protein
  • CG3695 protein
  • crsp3 protein
  • CRSP130 protein
  • CRSP133 protein
  • Dmel\\CG3695 protein
  • DRIP130 protein
  • dSUR2 protein
  • dTRAP150beta protein
  • ESTM7 protein
  • Gal11/SUR2 protein
  • MED23 protein
  • mKIAA1216 protein
  • MRT18 protein
  • si:ch211-272f15.2 protein
  • SUR-2 protein
  • Sur2 protein
  • Trap150 protein
  • Trap150beta protein
  • X83317 protein
  • zgc:91979 protein

Protein level used designations for MED23

CG3695-PA , CG3695-PB , MED23-PA , MED23-PB , mediator complex subunit 23 , mediator complex subunit n23 , cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa , Sp1 transcriptional activation cofactor subunit 3 , mediator of RNA polymerase II transcription subunit 23-like , mediator of RNA polymerase II transcription subunit 23 , 130 kDa transcriptional co-activator , 133 kDa transcriptional co-activator , activator-recruited cofactor 130 kDa component , cofactor required for Sp1 transcriptional activation subunit 3 , vitamin D3 receptor interacting protein , CRSP complex subunit 3 , cofactor required for Sp1 transcriptional activation, subunit 3 (130kD) , mSur-2 , protein sur-2 homolog , cofactor required for Sp1 transcriptional activation, subunit 3

GENE ID SPECIES
37639 Drosophila melanogaster
426927 Gallus gallus
472124 Pan troglodytes
474822 Canis lupus familiaris
100067556 Equus caballus
100342894 Oryctolagus cuniculus
100409950 Callithrix jacchus
100433008 Pongo abelii
100545205 Meleagris gallopavo
100562268 Anolis carolinensis
100602785 Nomascus leucogenys
412332 Apis mellifera
100466100 Ailuropoda melanoleuca
9439 Homo sapiens
70208 Mus musculus
309565 Rattus norvegicus
445483 Danio rerio
399060 Xenopus laevis
513610 Bos taurus
173345 Caenorhabditis elegans
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