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May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Additionally we are shipping MEMO1 Antibodies (16) and MEMO1 Kits (5) and many more products for this protein.
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Human MEMO1 Protein expressed in Escherichia coli (E. coli) - ABIN1098329
Zaoui, Benseddik, Daou, Salaün, Badache: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 2 references for ABIN1098329
Biochemical assays revealed that Memo is a copper-dependent redox enzyme that promoted a more oxidized intracellular milieu and stimulated the production of reactive oxygen species (ROS (show ROS1 Proteins)) in cellular structures involved in migration.
Mediator of ERBB2 (show ERBB2 Proteins)-driven cell motility (MEMO) promotes extranuclear estrogen receptor (show ESR1 Proteins) signaling involving the growth factor receptors IGF1R (show IGF1R Proteins) and ERBB2 (show ERBB2 Proteins).
MEMO1 is involved in breast carcinogenesis via regulating insulin-like growth factor-I receptor (show IGF1R Proteins)-dependent signaling events.
data suggest that Memo controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton [Memo]
Memo-RhoA-mDia1 signaling coordinates the organization of the lamellipodial actin network, adhesion site formation, and microtubule outgrowth within the cell leading edge to sustain cell motility.
Memo was detected in complexes with cofilin (show CFL1 Proteins), ErbB2 (show ERBB2 Proteins) and PLCgamma1 (show PLCG1 Proteins).
our results show that Memo has a novel role in the S1P (show S1PR1 Proteins) pathway and that Memo is needed to promote cell-autonomous S1PR activation.
tissue distribution of Memo in mice.
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
, C21orf19-like protein
, protein memo
, mediator of ErbB2-driven cell motility 1
, mediator of cell motility 1
, Methylation modifier for class I HLA
, HCV NS5A-transactivated protein 7
, hepatitis C virus NS5A-transactivated protein 7