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MEFV encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Additionally we are shipping Mediterranean Fever Antibodies (64) and Mediterranean Fever Proteins (4) and many more products for this protein.
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the presence of homozygous M694V gene mutation seems to increase the risk for periodontitis in familial Mediterranean fever patients.
Describe the MEFV mutational spectrum and distribution in a healthy Turkish population, and report a carrier rate that is much higher than expected.
This study shows that p.M694I homozygosity in MEFV is a potential genetic risk factor for the development of renal AA-amyloidosis in Algerian Familial Mediterranean fever patients.
Fever and MEFV gene M694V homozygosity were less frequently detected in Familial Mediterranean fever.
Correlate MEFV genotype and the SAA1 (show SAA1 ELISA Kits) polymorphisms with the clinical manifestations of familial Mediterranean fever and the occurrence of amyloidosis in a large cohort of Armenian patients.
a guard-like mechanism of pyrin regulation, originally identified for Nod-like receptors in plant innate immunity, also exists in humans.
Most patients presenting with PFAPA syndrome have heterozygous MEFV gene mutations.
When compared with the control group, a lower prevalence of the MEFV gene mutation carrier was found in sarcoidosis patients but this was not statistically significant.
This is the first report of non-transmitted, acquired familial Mediterranean fever, associated with a Janus Kinase 2 (show JAK2 ELISA Kits) driven clonal expansion of a somatic Mediterranean fever gene exon 10 mutation.
As colchicine treatment not only improved the myofascial pain but also prevented FMF-associated amyloidosis and nephropathy, differential diagnosis of fibromyalgia in patients of Mediterranean origin should include FMF and a genetic screening of MEFV.
These results are consistent with a model in which pyrin acts to limit the release of IL-1beta (show IL1B ELISA Kits) generated by activation and assembly of inflammasomes in response to subclinical immune challenges.
pyrin has a critical role in the innate immune response, possibly by acting on ASC (show STS ELISA Kits), a known caspase-1 (show CASP1 ELISA Kits) activator
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome.
Mediterranean fever protein
, Mediterranean fever
, familial mediterranean fever