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Megakaryocyte-Associated tyrosine Kinase Proteins (MATK)

The protein encoded by MATK has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. Additionally we are shipping Megakaryocyte-Associated tyrosine Kinase Antibodies (102) and Megakaryocyte-Associated tyrosine Kinase Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MATK 4145 P42679
MATK 17179 P41242
MATK 60450 P41243
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Top Megakaryocyte-Associated tyrosine Kinase Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,314.67
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MATK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Megakaryocyte-Associated tyrosine Kinase (MATK) Interaction Partners

Human Megakaryocyte-Associated tyrosine Kinase (MATK) interaction partners

  1. After IGF-I (show IGF1 Proteins) stimulation, CTK is recruited to IGF-IR and its recruitment facilitates CTK's subsequent association with phospho-SHPS-1 (show SIRPA Proteins).

  2. ERBB2 binds to the SH2 domain of CHK and inhibits cell growth in human breast tumor cell lines

  3. Overexpression of the Csk homologous kinase facilitates phosphorylation of akt/protein kinase b (show AKT1 Proteins) in breast neoplasms

  4. CHK (show CHKA Proteins) Leu223 stabilizes the movement of the alphaC-helix of the protein tyrosine kinase (show EPHA8 Proteins)

  5. Loss of CHK expression is associated with human brain tumors

  6. Nuclear multi-lobulation in late S phase, which is dependent on polymerization and depolymerization of microtubules, may be involved in nuclear Chk-induced inhibition of proliferation.

  7. striking functional differences between the Csk and Chk SH2 domains and revealed functional similarities between the Chk and Src SH2 domains

  8. This study describes for the first time the Src-independent actions of CHK and provides novel insights into CHK function in neural cells.

  9. Matk/CHK is not functionally redundant with Csk (show CSK Proteins), and this tyrosine kinase (show TXK Proteins) plays an important role as a regulator of immunologic responses

  10. Findings indicate that the importance of the N-terminal domain to Chk-induced tyrosine phosphorylation in the nucleus, and implicate that nuclear tyrosine-phosphorylated proteins may contribute to inhibition of cell proliferation.

Cow (Bovine) Megakaryocyte-Associated tyrosine Kinase (MATK) interaction partners

  1. After IGF-I (show IGF1 Proteins) stimulation, CTK is recruited to IGF-IR and its recruitment facilitates CTK's subsequent association with phospho-SHPS-1 (show SIRPA Proteins).

Megakaryocyte-Associated tyrosine Kinase (MATK) Protein Profile

Protein Summary

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.

Gene names and symbols associated with MATK

  • megakaryocyte-associated tyrosine kinase (matk)
  • megakaryocyte-associated tyrosine kinase (MATK)
  • megakaryocyte-associated tyrosine kinase (Matk)
  • Batk protein
  • CHK protein
  • CTK protein
  • HHYLTK protein
  • HYL protein
  • HYLTK protein
  • Lsk protein
  • Ntk protein
  • si:ch211-63j24.2 protein

Protein level used designations for MATK

megakaryocyte-associated tyrosine kinase , megakaryocyte-associated tyrosine-protein kinase-like , CSK homologous kinase , Csk-homologous kinase , Csk-type protein tyrosine kinase , HYL tyrosine kinase , hematopoietic consensus tyrosine-lacking kinase , hydroxyaryl-protein kinase , leukocyte carboxyl-terminal src kinase related , megakaryocyte-associated tyrosine-protein kinase , protein kinase HYL , tyrosine kinase MATK , tyrosine-protein kinase CTK , tyrosylprotein kinase , Csk homologous kinase , protein kinase NTK , megakaryocyte-associated tyrosine kinase (non-receptor protein tyrosine kinase) , non-receptor protein kinase protein , protein kinase BATK , carboxyl-terminal SRC kinase homologous kinase

GENE ID SPECIES
567405 Danio rerio
769076 Gallus gallus
100477232 Ailuropoda melanoleuca
4145 Homo sapiens
17179 Mus musculus
60450 Rattus norvegicus
611999 Canis lupus familiaris
100521543 Sus scrofa
504668 Bos taurus
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