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MEIS2 encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. Additionally we are shipping MEIS2 Antibodies (92) and MEIS2 Proteins (6) and many more products for this protein.
we have identified a novel nonsense MEIS2 mutation in a female patient with cleft palate, cardiac septal defect, severe ID, developmental delay and feeding difficulty with gastro-esophageal reflux. Our findings strongly suggest neurocristopathy be included in the clinical features associated with MEIS2 alterations.
Meis2 as the target of miR (show MLXIP ELISA Kits)-134 in the regulation of cardiomyocyte progenitor cell proliferation.
This is the first report showing a de novo small intragenic mutation in MEIS2 and further confirms the important role of this gene in normal development.
Our results show that MEIS2 is a gene needed for palate closure. In syndromic cases of cleft palate, MEIS2 should be considered among the candidate genes, for example, in cases without 22q11.2 deletions.
FOXM1 (show FOXM1 ELISA Kits) is a direct target gene of MEIS2 and is required for MEIS2 to upregulate mitotic genes.
The data suggest existence of a complex regulatory pathway in the trabecular meshwork part of which includes interactions between FOXC1 (show FOXC1 ELISA Kits), miR (show MLXIP ELISA Kits)-204, MEIS2, and ITGbeta1.
Klf4 (show KLF4 ELISA Kits) recruits a complex of Meis and Pbx proteins to DNA, resulting in Meis2 transcriptional activation domain-dependent activation of a subset of Klf4 (show KLF4 ELISA Kits) target genes.
The Single Nucleotide Polymorphism in Meis homeobox 2 (MEIS2) mediated the effects of risperidone on hip circumference (q=0.004).
Transgenic mice lacking microRNAs miR (show MLXIP ELISA Kits)-9-2 and miR (show MLXIP ELISA Kits)-9-3 exhibit multiple defects of telencephalic structures which may be brought about by dysregulation of Foxg1 (show FOXG1 ELISA Kits), Nr2e1 (show NR2E1 ELISA Kits), Gsh2 (show GSX2 ELISA Kits), and Meis2 expression.
Data demonstrate by in situ hybridization and immunohistochemistry that the two homeobox (show Lbx1 ELISA Kits) genes Pax6 (show PAX6 ELISA Kits) and MEIS2 are expressed during early fetal brain development in humans.
MEIS2 associates with chromatin-bound PBX1 (show PBX1 ELISA Kits), recruits PARP1/ARTD1 (show PARP1 ELISA Kits), and initiates PARP1 (show PARP1 ELISA Kits)-mediated eviction of H1 from the chromatin fiber.
An intrinsic constitutively activated feedforward signaling circuit composed of IkappaBalpha (show NFKBIA ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits)(p65 (show NFkBP65 ELISA Kits)), miR (show MLXIP ELISA Kits)-196b-3p, Meis2, and PPP3CC (show PPP3CC ELISA Kits) is formed during the emergence of castration-resistant prostate cancer.
Hoxa2 (show HOXA2 ELISA Kits), Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 (show HMX1 ELISA Kits) expression.
We found that expression of Emx2 (show EMX2 ELISA Kits) and Lhx2 (show LHX2 ELISA Kits) initiated between neuronal progenitor and neuronal precursor stages. As far as the sensory neurons of the vomeronasal organ are concerned, Meis1 (show MEIS1 ELISA Kits) and Meis2 were only expressed in the apical layer, together with Gnai2 (show GNAI2 ELISA Kits), but not in the basal layer.
we show that simultaneous deletion of Meis1 (show MEIS1 ELISA Kits) and Meis2 in presumptive lens ectoderm results in arrested lens development in the pre-placodal stage, and neither lens placode nor lens is formed. We found that in the presumptive lens ectoderm of Meis1 (show MEIS1 ELISA Kits)/Meis2 deficient embryos Pax6 (show PAX6 ELISA Kits) expression is absent
Meis2-null mice are embryonic lethal. The results reveal a critical role of Meis2 during cranial and cardiac neural crest cells development in mouse.
Data suggest that the RING1 (show RING1 ELISA Kits)-MEIS1 (show MEIS1 ELISA Kits)/2 axis is regulated by early PD signals and contributes to the initiation or maintenance of the distal signal circuitry.
Interaction of Meis2 promoter with midbrain enhancer depends on RING1.
Meis2 cooperates with Pax6 (show PAX6 ELISA Kits) in generic neurogenesis and dopaminergic fate specification in the adult subventricular zone-olfactory bulb system.
These data identify Meis2 as a marker for the study of amacrine cell diversity and development in addition to providing evidence for the stepwise specification of the glycinergic and GABAergic neurotransmitter phenotypes during AM cell differentiation.
This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.
Meis homeobox 2
, homeobox protein Meis2-like
, homeobox protein Meis2
, myeloid ecotropic viral integration site 2.2
, XMeis1-3 protein
, Meis1, myeloid ecotropic viral integration site 1 homolog 2
, homeoprotein Meis2a.1
, homeoprotein Meis2a.2
, myeloid ecotropic viral insertion site-2a protein
, Meis homolog 2
, Meis1-related gene 1
, TALE homeobox protein Meis2
, meis1-related protein 1
, Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2
, myeloid ecotropic viral integration site-related gene 1
, myeloid ecotropic viral integration site 2.1