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Caudalizing protein which is required to pattern the anterior/posterior (A/P) axis during central nervous system (CNS) formation. Additionally we are shipping MEIS3 Proteins (7) and many more products for this protein.
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Chicken Polyclonal MEIS3 Primary Antibody for WB - ABIN2783067
Shim, Kim, Shin, Kim, Park: Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon. in Molecular and cellular biology 2007
hindbrain-repressive Wnt3a/Meis3/Tsh1 circuit promotes neuronal differentiation and coordinates tissue maturation
Synergy between XMeis3 and Hoxd1 (show HOXD1 Antibodies) in Hoxd1 (show HOXD1 Antibodies) autoregulation in mesoderm during gastrulation, is shown.
XMeis3 protein knock down also causes a loss of primary neuron and neural crest cell lineages, without altering expression of Zic (show ZIC1 Antibodies), Sox (show PIPOX Antibodies) or Pax3 (show PAX3 Antibodies) genes.
XMeis3 activates FGF/MAP-kinase (show MAPK1 Antibodies) signaling, which then modulates the PCP (show PRCP Antibodies) pathway.
XMeis3 protein appears crucial for initial hindbrain induction, whereas Retinoic Acid signaling defines the spatial limits of hindbrain gene expression by modifying XMeis3 protein activity
Findings support a model in which Meis3 is required for neural crest proliferation, migration into, and colonization of the gut (show GUSB Antibodies) such that its loss leads to severe defects in enteric nervous system development.
This work suggests that the transcriptional activity of all members of the Meis/Prep Hth protein family is subject to autoinhibition by their Hth domains, and that the Meis3.2 splice variant encodes a protein that bypasses this autoinhibitory effect.
Data have demonstrated the presence of Meis, Pbx, and Prep proteins during early lineage segregation in mammals: Meis1, Meis3, Pbx1, Pbx2, Pbx3, and Prep1 in the mouse.
Meis3 is abundantly expressed in pancreatic islets and beta-cells and regulates beta-cell survival through 3-phosphoinositide-dependent protein kinase 1 (PDK1 (show PDPK1 Antibodies)).
Novel collaboration between Icsbp (show IRF8 Antibodies) deficiency and Meis1/Meis3 in the acceleration of chronic myeloid leukemia (show BCL11A Antibodies)-like disease.
Meis3 and pbx4 (show PBX4 Antibodies) regulate shh (show SHH Antibodies) expression in anterior endoderm, thereby influencing patterning and growth of the foregut.
Caudalizing protein which is required to pattern the anterior/posterior (A/P) axis during central nervous system (CNS) formation. Inhibits anterior neural expression and acts as a transcriptional activator to induce posterior neural gene expression. Maintains a proper A/P balance required for hindbrain formation by activating the FGF/MAPK pathway, which modulates the planar cell polarity (PCP) pathway. Interacts with retinoid signaling during hindbrain patterning.
homeobox protein meis3-B
, Meis1, myeloid ecotropic viral integration site 1 homolog
, homeobox protein meis3
, Meis homeobox 3
, Meis homeobox 3 pseudogene 1
, Meis1, myeloid ecotropic viral integration site 1 homolog 3
, homeobox protein Meis3
, meis1-related protein 2
, Meis3 homeoprotein
, homeobox protein meis3-A
, myeloid ecotropic viral integration site-related gene 2