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anti-Melanocortin 2 Receptor (Adrenocorticotropic Hormone) (MC2R) Antibodies

MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Additionally we are shipping MC2R Kits (42) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MC2R 282839  
MC2R 17200 Q64326
MC2R 4158 Q01718
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Top anti-MC2R Antibodies at antibodies-online.com

Showing 10 out of 73 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IHC (p), WB MC2R Antibody (C-term) (ABIN651731) western blot analysis in WiDr cell line lysates (15 µg/lane). This demonstrates the MC2R antibody detected the MC2R protein (arrow). MC2R Antibody (C-term) (ABIN651731) immunohistochemistry analysis in formalin fixed and paraffin embedded human skin carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from HeLa cells, using ACTHR Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of MCF7 cells, using ACTHR Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated ELISA, WB ABIN238653 (1µg/ml) staining of Human Skin lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Rat Rabbit Un-conjugated IHC, WB Western blot analysis of rat adrenal lysate: 1. Anti-Melanocortin Receptor 2 (extracellular) antibody, (1:400). 2. Anti-Melanocortin Receptor 2 (extracellular) antibody, preincubated with the control peptide antigen. Expression of MC2R in rat adrenal gland Immunohistochemical staining of paraffin embedded rat adrenal cortex section using Anti-Melanocortin Receptor 2 (extracellular) antibody, (1:100). Shown are the capsule (C), the zona glomerulosa (ZG) and the zona fasciculata (ZF) of the adrenal cortex. Note that the staining brown) is specific for cells of the adrenal gland while no staining is present in the dense connective tissue of the capsule. Color reaction was obtained with DAB. H&E is used as the counterstain. 50 μL Log in to see 10 to 11 Days
$678.57
Details
Human Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

MC2R Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-MC2R Antibodies

  1. Human Polyclonal MC2R Primary Antibody for FACS, IHC (p) - ABIN651731 : Roy, Perron, Gallo-Payet: Role of asparagine-linked glycosylation in cell surface expression and function of the human adrenocorticotropin receptor (melanocortin 2 receptor) in 293/FRT cells. in Endocrinology 2010 (PubMed)
    Show all 2 references for ABIN651731

  2. Rat (Rattus) Polyclonal MC2R Primary Antibody for IHC, WB - ABIN1742044 : Gantz, Fong: The melanocortin system. in American journal of physiology. Endocrinology and metabolism 2003 (PubMed)

  3. Human Polyclonal MC2R Primary Antibody for WB - ABIN374914 : Kilianova, Basora, Kilian, Payet, Gallo-Payet: Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization. in Endocrinology 2006 (PubMed)

  4. Human Polyclonal MC2R Primary Antibody for IF, ELISA - ABIN1535648 : Mountjoy, Robbins, Mortrud, Cone: The cloning of a family of genes that encode the melanocortin receptors. in Science (New York, N.Y.) 1992 (PubMed)

More Antibodies against MC2R Interaction Partners

Zebrafish Melanocortin 2 Receptor (Adrenocorticotropic Hormone) (MC2R) interaction partners

  1. zfMC2R is not functional in the absence of MRAP expression.

Rainbow Trout (Oncorhynchus mykiss) Melanocortin 2 Receptor (Adrenocorticotropic Hormone) (MC2R) interaction partners

  1. Data suggest enzymes in steroidogenic pathway are induced in interrenal cells during acute/chronic stress: MC2R (melanocortin 2 receptor); StAR (steroidogenic acute regulatory protein (show STAR Antibodies)); 3beta-hydroxysteroid dehydrogenase; steroid 11beta hydroxylase.

  2. Rainbow trout melanocortin-2 receptor structure and function analysis.

  3. ACTH (show POMC Antibodies) regulation of MC2R is highly conserved in vertebrates.

Mouse (Murine) Melanocortin 2 Receptor (Adrenocorticotropic Hormone) (MC2R) interaction partners

  1. Data show that neuromedin B (NMB) expression was higher in the melanocortin 2 receptor MC2R(-/-) than in the wild-type (WT) mice.

  2. MC2R plays an important role for regular lipolytic function and lipid composition in 3T3-L1 adipocytes.

  3. melanocortin 2 receptor and melanocortin 5 receptor (show MC5R Antibodies) are lipolytic mediators in differentiated 3T3-L1 adipocytes

  4. MC2R+/- pups delivered from MC2R-/- females crossed with MC2R+/+ males mice thrived poorly with MC2R-/- mothers but grew to adulthood when transferred to foster mothers after birth, suggesting that MC2R-/- females are poor mothers or cannot nurse.

  5. The promoter activity of Mc2r is activated by FOXL2 (show FOXL2 Antibodies) in a dose-dependent manner; transcriptional activity of Mc2r is up-regulated by synergistic interaction of FOXL2 (show FOXL2 Antibodies) and NR5A1 (show NR5A1 Antibodies).

  6. Data show that melanocortins regulate Il6 (show IL6 Antibodies) gene expression and production in 3T3-L1 adipocytes through melanocortin receptors 2 and 5.

  7. MC2R in Y1 cells internalizes by a G protein coupled receptor (show GPR34 Antibodies) kinase dependent clathrin-coated pit (show IRF6 Antibodies) mechanism.

  8. Data show that adrenocorticotrophic hormone resistance in tumor cell mutants is associated with a base change polymorphism in the steroidogenic factor 1 (show NR5A1 Antibodies) gene.

  9. Novel 135-bp exon 1f of ACTH-R gene was located 1.4 kb downstream in genome of exon 1a transcribed in adrenal gland. Promoter region flanking to exon 1f may be essential for adipose tissue; that flanking to exon 1a is specific for the adrenal gland.

  10. a novel mechanism for mc2-r transcription, which may have significance in both adrenal and extra-adrenal sites of expression

Human Melanocortin 2 Receptor (Adrenocorticotropic Hormone) (MC2R) interaction partners

  1. melanocortin receptors MC2R, MC3R (show MC3R Antibodies) and MC5R (show MC5R Antibodies) are most abundantly expressed in glandular epithelium of the endometrium

  2. MC2R and MC1R (show MSHR Antibodies) signals are consecutively required for the regulation of EPO (show EPO Antibodies) signal transduction in erythroblast differentiation, and MC5R (show MC5R Antibodies) signal transduction is required to induce enucleation.

  3. the MC2R gene may contribute to the development of intracerebral hemorrhage.

  4. The A allele at rs1941088 in the MC2R gene, which encodes the adrenocorticotropic hormone (corticotropin, ACTH) receptor, is associated with a low cortisol response in critically ill children.

  5. results suggest that Phe(7) in ACTH (show POMC Antibodies) plays an important role in ligand selectivity and that the third transmembrane domain of MC2R is crucial for ACTH (show POMC Antibodies) selectivity and potency

  6. MC2R overexpression is associated with myelolipomas.

  7. The patient with familial glucocorticoid deficiency was found to be homozygous for a novel mutation in the melanocortin-2 receptor gene (635insC, I154H).

  8. Our observations suggest that MC2R is involved in prostate carcinogenesis and that targeting MC2R signaling may provide a novel avenue in prostate carcinoma treatment.

  9. The ACTHR gene -2T>C variant may be one important factor that influences stress perception of patients with alopecia areata.

  10. Significant differences in the gene expression of aldosterone synthase (show CYP11B2 Antibodies) and adrenocorticotropic hormone receptor distinguishes adrenal neoplasms from primary aldosteronism.

MC2R Antigen Profile

Protein Summary

MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency.

Gene names and symbols associated with MC2R

  • melanocortin 2 receptor (adrenocorticotropic hormone) (MC2R) antibody
  • adrenocorticotropic hormone receptor (ACTHR) antibody
  • melanocortin 2 receptor (adrenocorticotropic hormone) (Mc2r) antibody
  • melanocortin 2 receptor (mc2r) antibody
  • melanocortin 2 receptor (LOC100222030) antibody
  • adrenocorticotropic hormone receptor-like (LOC100739231) antibody
  • adrenocorticotropic hormone receptor-like (LOC100855756) antibody
  • melanocortin 2 receptor (Mc2r) antibody
  • ACTH-R antibody
  • ACTHR antibody
  • MC2 antibody
  • MC2-R antibody
  • MC2R antibody

Protein level used designations for MC2R

melanocortin 2 receptor (adrenocorticotropic hormone) , adrenocorticotropic hormone receptor , melanocortin 2 receptor , G-protein-coupled receptor , melanocortin 2 receptor-like , putative melanocortin 2 receptor , ACTH receptor , Adrenocorticotropin receptor , Melanocortin receptor 2 , adrenocorticotropin receptor , melanocortin receptor 2 , ACTH-R , ACTH-receptor , MC2 receptor , corticotropin receptor , MC2-R , melanocortin 2 receptor (adrenocorticotropic hormone receptor) , adrenal ACTH receptor , melanocortin 2-receptor

GENE ID SPECIES
397427 Sus scrofa
483980 Canis lupus familiaris
692350 Felis catus
282839 Rattus norvegicus
353152 Danio rerio
445998 Takifugu rubripes
100136719 Oncorhynchus mykiss
100222030 Taeniopygia guttata
100739231 Sus scrofa
100855756 Canis lupus familiaris
17200 Mus musculus
100135574 Cavia porcellus
4158 Homo sapiens
281299 Bos taurus
443482 Ovis aries
428516 Gallus gallus
101825745 Mesocricetus auratus
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