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MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Additionally we are shipping MC2R Kits (42) and and many more products for this protein.
Showing 10 out of 72 products:
Human Polyclonal MC2R Primary Antibody for FACS, IHC (p) - ABIN651731
Roy, Perron, Gallo-Payet: Role of asparagine-linked glycosylation in cell surface expression and function of the human adrenocorticotropin receptor (melanocortin 2 receptor) in 293/FRT cells. in Endocrinology 2010
Show all 2 references for ABIN651731
Rat (Rattus) Polyclonal MC2R Primary Antibody for IHC, WB - ABIN1742044
Gantz, Fong: The melanocortin system. in American journal of physiology. Endocrinology and metabolism 2003
Human Polyclonal MC2R Primary Antibody for WB - ABIN374914
Kilianova, Basora, Kilian, Payet, Gallo-Payet: Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization. in Endocrinology 2006
Human Polyclonal MC2R Primary Antibody for IF, ELISA - ABIN1535648
Mountjoy, Robbins, Mortrud, Cone: The cloning of a family of genes that encode the melanocortin receptors. in Science (New York, N.Y.) 1992
zfMC2R is not functional in the absence of MRAP expression.
Data suggest enzymes in steroidogenic pathway are induced in interrenal cells during acute/chronic stress: MC2R (melanocortin 2 receptor); StAR (steroidogenic acute regulatory protein (show STAR Antibodies)); 3beta-hydroxysteroid dehydrogenase; steroid 11beta hydroxylase.
Rainbow trout melanocortin-2 receptor structure and function analysis.
ACTH (show POMC Antibodies) regulation of MC2R is highly conserved in vertebrates.
Data show that neuromedin B (NMB) expression was higher in the melanocortin 2 receptor MC2R(-/-) than in the wild-type (WT) mice.
MC2R plays an important role for regular lipolytic function and lipid composition in 3T3-L1 adipocytes.
melanocortin 2 receptor and melanocortin 5 receptor (show MC5R Antibodies) are lipolytic mediators in differentiated 3T3-L1 adipocytes
MC2R+/- pups delivered from MC2R-/- females crossed with MC2R+/+ males mice thrived poorly with MC2R-/- mothers but grew to adulthood when transferred to foster mothers after birth, suggesting that MC2R-/- females are poor mothers or cannot nurse.
The promoter activity of Mc2r is activated by FOXL2 (show FOXL2 Antibodies) in a dose-dependent manner; transcriptional activity of Mc2r is up-regulated by synergistic interaction of FOXL2 (show FOXL2 Antibodies) and NR5A1 (show NR5A1 Antibodies).
Data show that melanocortins regulate Il6 (show IL6 Antibodies) gene expression and production in 3T3-L1 adipocytes through melanocortin receptors 2 and 5.
MC2R in Y1 cells internalizes by a G protein coupled receptor (show GPR34 Antibodies) kinase dependent clathrin-coated pit (show IRF6 Antibodies) mechanism.
Data show that adrenocorticotrophic hormone resistance in tumor cell mutants is associated with a base change polymorphism in the steroidogenic factor 1 (show NR5A1 Antibodies) gene.
Novel 135-bp exon 1f of ACTH-R gene was located 1.4 kb downstream in genome of exon 1a transcribed in adrenal gland. Promoter region flanking to exon 1f may be essential for adipose tissue; that flanking to exon 1a is specific for the adrenal gland.
a novel mechanism for mc2-r transcription, which may have significance in both adrenal and extra-adrenal sites of expression
melanocortin receptors MC2R, MC3R (show MC3R Antibodies) and MC5R (show MC5R Antibodies) are most abundantly expressed in glandular epithelium of the endometrium
MC2R and MC1R (show MSHR Antibodies) signals are consecutively required for the regulation of EPO (show EPO Antibodies) signal transduction in erythroblast differentiation, and MC5R (show MC5R Antibodies) signal transduction is required to induce enucleation.
the MC2R gene may contribute to the development of intracerebral hemorrhage.
The A allele at rs1941088 in the MC2R gene, which encodes the adrenocorticotropic hormone (corticotropin, ACTH) receptor, is associated with a low cortisol response in critically ill children.
results suggest that Phe(7) in ACTH (show POMC Antibodies) plays an important role in ligand selectivity and that the third transmembrane domain of MC2R is crucial for ACTH (show POMC Antibodies) selectivity and potency
MC2R overexpression is associated with myelolipomas.
The patient with familial glucocorticoid deficiency was found to be homozygous for a novel mutation in the melanocortin-2 receptor gene (635insC, I154H).
Our observations suggest that MC2R is involved in prostate carcinogenesis and that targeting MC2R signaling may provide a novel avenue in prostate carcinoma treatment.
The ACTHR gene -2T>C variant may be one important factor that influences stress perception of patients with alopecia areata.
Significant differences in the gene expression of aldosterone synthase (show CYP11B2 Antibodies) and adrenocorticotropic hormone receptor distinguishes adrenal neoplasms from primary aldosteronism.
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency.
melanocortin 2 receptor (adrenocorticotropic hormone)
, adrenocorticotropic hormone receptor
, melanocortin 2 receptor
, G-protein-coupled receptor
, melanocortin 2 receptor-like
, putative melanocortin 2 receptor
, ACTH receptor
, Adrenocorticotropin receptor
, Melanocortin receptor 2
, adrenocorticotropin receptor
, melanocortin receptor 2
, MC2 receptor
, corticotropin receptor
, melanocortin 2 receptor (adrenocorticotropic hormone receptor)
, adrenal ACTH receptor
, melanocortin 2-receptor