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MAGEA11 is a member of the MAGEA gene family. Additionally we are shipping MAGEA11 Antibodies (61) and many more products for this protein.
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degradation of MAGE-A11 promoted by the human p14-ARF tumor suppressor contributes to low levels of MAGE-A11 in nontransformed cells
MAGE-A9 and MAGE-A11 are tumor-specific antigens and not only DNA hypermethylation but also histone deacetylation is responsible for the mechanism underlying MAGE-A9 and MAGE-A11 gene silencing.
MAGE (show MAGEB10 Proteins)-A11, similarly to HER-2 (show ERBB2 Proteins) and ER-beta (show ESR2 Proteins), may be an important diagnostic or prognostic indicator in breast cancer and potentially promotes tumor proliferation.
MAGEA11 regulation is highly instructive for understanding mechanisms regulating CG antigen genes in human cancer.
MAGE (show MAGEB10 Proteins)-A11 is a proto-oncogene (show RAB1A Proteins) whose increased expression in prostate cancer reverses retinoblastoma-related protein p107 (show RBL1 Proteins) from a transcriptional repressor to a transcriptional activator of the androgen receptor (show AR Proteins) and E2F1 (show E2F1 Proteins).
MAGE (show MAGEB10 Proteins)-A11 increases AR transcriptional activity by linking androgen receptor (show AR Proteins) dimers.
Gain in transcriptional activity by primate-specific coevolution of melanoma antigen-A11 and its interaction site in androgen receptor (show AR Proteins).
MAGE-11 links NH(2)-terminal domains of AR and p300 (show EP300 Proteins) to promote transcriptional synergy through a cadre of FXXLF-related interacting motifs
Results suggest that MAGE-11 functions as a bridging factor to recruit androgen receptor (show AR Proteins) coactivators through a novel FXX(L/I)F motif-F-box interaction paradigm.
MAGE-11 is a unique AR coregulator that increases AR activity by modulating the AR interdomain interaction.
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene.
melanoma-associated antigen 11
, melanoma antigen family A, 11
, melanoma-associated antigen 11-like
, MAGE-11 antigen
, cancer/testis antigen 1.11
, cancer/testis antigen family 1, member 11