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MAGEA11 is a member of the MAGEA gene family. Additionally we are shipping MAGEA11 Antibodies (64) and many more products for this protein.
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direct interactions of MAGE-A11 with Skp2 and cyclin A regulate the substrate-specificity of Skp2-mediated protein degradation.
MageA6 (show MAGEA3 Proteins) and MageA11 form a protein complex resulting in the stabilization of MageA11 and consequently the enhancement of androgen receptor (show AR Proteins) activity.
MAGE (show MAGEB10 Proteins)-A11 and androgen receptor (show AR Proteins) cooperate in the up-regulation of FSTL1 (show FSTL1 Proteins) to promote the growth of prostate cancer.
MAGE-A11 is an independent poor prognostic marker for esophageal squamous cell carcinoma (ESCC) patients. MAGE-A11 regulates various cell functions and directly increases the invasion and proliferation of ESCC cells.
The overall survival of laryngeal squamous cell carcinoma patients with positive MAGE-A1, MAGE-A9, or MAGE-A11 expression was lower than the patients without MAGE-A1, MAGE-A9, or MAGE-A11 expression.
degradation of MAGE-A11 promoted by the human p14-ARF tumor suppressor contributes to low levels of MAGE-A11 in nontransformed cells
MAGE-A9 and MAGE-A11 are tumor-specific antigens and not only DNA hypermethylation but also histone deacetylation is responsible for the mechanism underlying MAGE-A9 and MAGE-A11 gene silencing.
MAGE (show MAGEB10 Proteins)-A11, similarly to HER-2 (show ERBB2 Proteins) and ER-beta (show ESR2 Proteins), may be an important diagnostic or prognostic indicator in breast cancer and potentially promotes tumor proliferation.
MAGEA11 regulation is highly instructive for understanding mechanisms regulating CG antigen genes in human cancer.
MAGE (show MAGEB10 Proteins)-A11 is a proto-oncogene (show RAB1A Proteins) whose increased expression in prostate cancer reverses retinoblastoma-related protein p107 (show RBL1 Proteins) from a transcriptional repressor to a transcriptional activator of the androgen receptor (show AR Proteins) and E2F1 (show E2F1 Proteins).
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene.
melanoma-associated antigen 11
, melanoma antigen family A, 11
, melanoma-associated antigen 11-like
, MAGE-11 antigen
, cancer/testis antigen 1.11
, cancer/testis antigen family 1, member 11