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MAGEA2 is a member of the MAGEA gene family. Additionally we are shipping MAGEA2 Antibodies (37) and many more products for this protein.
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We find that MAGE-A2 interacts with MDM2 (show MDM2 Proteins) via the N-terminal p53 (show TP53 Proteins)-binding pocket and the RING finger (show PCGF1 Proteins) domain of MDM2 (show MDM2 Proteins) that is required for homo/hetero-dimerization and for E2 ligase interaction.
Consistent with increased cell death, the induced loss of MAGEA2 expression correlated with increased caspase 3 (show CASP3 Proteins)/7 activity, BCL2 (show BCL2 Proteins)/BAX (show BAX Proteins) ratio and TUNEL signal.
MAGEA2 has a critical role in the development of tamoxifen-resistant breast cancer
MageA2 interferes with p53 (show TP53 Proteins) acetylation at PML (show PML Proteins)-nuclear bodies (NBs (show NBN Proteins)) and with PMLIV-dependent activation of p53 (show TP53 Proteins).
Report MAGEA1 (show MAGEA1 Proteins)-A6 expression in sputum suggests presence of lung cancer cells or precancerous cells.
These data suggest that MAGEA2 is differentially expressed in HNSCC and functions, in part, through the p53 (show TP53 Proteins) pathway by increasing cellular proliferation and abrogating cell cycle arrest.
MAGE-A2 targets p53 (show TP53 Proteins) transactivation function through histone deacetylase (show HDAC1 Proteins) recruitment
These data show, for the first time, the involvement of methyl-CpG binding domain proteins in the regulation of the MAGE (show MAGEB10 Proteins)-A genes.
Multiple simultaneous detection of MAGE (show MAGEB10 Proteins)-A [subtypes] more specific and sensitive than detection of single MAGE (show MAGEB10 Proteins)-A antigen for the diagnostic and prognostic evaluation of oral squamous cell carcinoma
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.
melanoma antigen family A, 2
, MAGE-2 antigen
, cancer/testis antigen 1.2
, cancer/testis antigen family 1, member 2
, melanoma antigen 2
, melanoma-associated antigen 2