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anti-Melanoma Cell Adhesion Molecule (MCAM) Antibodies

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Additionally we are shipping MCAM Proteins (28) and MCAM Kits (22) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MCAM 4162 P43121
MCAM 84004 Q8R2Y2
MCAM 78967 Q9EPF2
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Top anti-MCAM Antibodies at antibodies-online.com

Showing 10 out of 304 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of MCAM Antibody 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse FITC EIA, FACS, IHC (fro)   0.1 mg Log in to see 6 to 8 Days
$533.50
Details
Chicken Mouse Un-conjugated FACS, IHC (fro), IP 0.5 mg Log in to see 6 to 8 Days
$357.50
Details
Human Mouse Un-conjugated IHC, ELISA, WB 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Human Mouse Un-conjugated FACS, IHC, ELISA, WB 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Human Mouse Un-conjugated IF, WB Western blot analysis of MCAM on a human endothelial cell lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the anti- MCAM antibody. Immunofluorescent staining of human endothelial cells. 50 μg Log in to see 5 to 6 Days
$230.09
Details
Chicken Mouse Biotin FACS   0.5 mg Log in to see 6 to 8 Days
$445.50
Details
Chicken Mouse FITC FACS   0.5 mg Log in to see 6 to 8 Days
$489.50
Details
Human Mouse Un-conjugated IHC (fro), FACS, IHC (p), IP, WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated EIA, FACS, IHC (fro)   1 mg Log in to see 6 to 8 Days
$1,061.50
Details

MCAM Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-MCAM Antibodies

  1. Human Monoclonal MCAM Primary Antibody for EIA, FACS - ABIN119672 : Möbius-Winkler, Hilberg, Menzel, Golla, Burman, Schuler, Adams: Time-dependent mobilization of circulating progenitor cells during strenuous exercise in healthy individuals. in Journal of applied physiology (Bethesda, Md. : 1985) 2009 (PubMed)
    Show all 12 references for ABIN119672

  2. Human Monoclonal MCAM Primary Antibody for IF, WB - ABIN968422 : Anfosso, Bardin, Francès, Vivier, Camoin-Jau, Sampol, Dignat-George: Activation of human endothelial cells via S-endo-1 antigen (CD146) stimulates the tyrosine phosphorylation of focal adhesion kinase p125(FAK). in The Journal of biological chemistry 1998 (PubMed)
    Show all 4 references for ABIN968422

  3. Human Polyclonal MCAM Primary Antibody for EIA, WB - ABIN453743 : Malyszko, Malyszko, Kozminski, Pawlak, Mysliwiec: Adipokines, linking adipocytes and vascular function in hemodialyzed patients, may also be possibly related to CD146, a novel adhesion molecule. in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2008 (PubMed)
    Show all 3 references for ABIN453743

  4. Human Monoclonal MCAM Primary Antibody for FACS, IHC - ABIN1724844 : Wang, Yan: CD146, a multi-functional molecule beyond adhesion. in Cancer letters 2013 (PubMed)
    Show all 2 references for ABIN1724844

  5. Human Monoclonal MCAM Primary Antibody for IHC, ELISA - ABIN1724898 : Jouve, Despoix, Espeli, Gauthier, Cypowyj, Fallague, Schiff, Dignat-George, Vély, Leroyer: The involvement of CD146 and its novel ligand Galectin-1 in apoptotic regulation of endothelial cells. in The Journal of biological chemistry 2013 (PubMed)
    Show all 2 references for ABIN1724898

  6. Human Monoclonal MCAM Primary Antibody for EIA, FACS - ABIN119671 : Kuzu, Bicknell, Fletcher, Gatter: Expression of adhesion molecules on the endothelium of normal tissue vessels and vascular tumors. in Laboratory investigation; a journal of technical methods and pathology 1993 (PubMed)

  7. Chicken Monoclonal MCAM Primary Antibody for FACS - ABIN371422 : Vainio, Dunon, Aïssi, Dangy, McNagny, Imhof: HEMCAM, an adhesion molecule expressed by c-kit+ hemopoietic progenitors. in The Journal of cell biology 1997 (PubMed)

More Antibodies against MCAM Interaction Partners

Zebrafish Melanoma Cell Adhesion Molecule (MCAM) interaction partners

  1. CD146 regulates convergent extension movement during gastrulation

  2. In addition to the physiological angiogenesis during development, gicerin morphants efficiently blocked the tumor angiogenesis in zebrafish.

  3. CD146 protein expression has a role in vascular development in zebrafish

Human Melanoma Cell Adhesion Molecule (MCAM) interaction partners

  1. CD146 dexpression efines a subpopulation of human mesenchymal stem cells capable of bone formation and in vivo trans-endothelial migration.

  2. Results showed that CD146 promoted metastasis of hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cells and predicted poor prognosis of HCC (show FAM126A Antibodies) patients. CD146 induced epithelial mesenchymal transition through probably IL-8 (show IL8 Antibodies) up-regulation and STAT1 (show STAT1 Antibodies) down-regulation.

  3. Data indicate that CD146 antigen is an effective cell surface marker for enriching tumor-propagating cells (TPCs) in primary sarcomas.

  4. MUC18 is an independent prognostic factor for clear cell renal cell carcinoma (show MOK Antibodies)

  5. CD146 is a novel and useful marker for predicting senescence in human umbilical cord blood-derived Mesenchymal stem cells (hUCB-MSCs), and CD146 can potentially be applied in quality-control assessments of hUCB-MSC (show MSC Antibodies)-based therapy.

  6. ZBTB7A (show ZBTB7A Antibodies) directly binds to the promoter and transcriptionally represses the expression of MCAM, establishing ZBTB7A (show ZBTB7A Antibodies) as a bona fide transcriptional repressor of MCAM

  7. The expression of CD146 and HIF1a (show HIF1A Antibodies) was positively correlated with EGFR (show EGFR Antibodies) and CD31 (show HBA1 Antibodies), respectively in salivary gland adenoid cystic carcinoma.

  8. a model that CD166 (show ALCAM Antibodies) regulates MCAM through a signaling flow from activation of PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and c-Raf (show RAF1 Antibodies)/MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) signaling to the inhibition of potential MCAM ubiquitin E3 ligases, betaTrCP (show BTRC Antibodies) and Smurf1 (show SMURF1 Antibodies)

  9. Combined EpCAM (show EPCAM Antibodies)/MCAM CellSearch enrichment thus increased the CTC detection rate.

  10. Results identified MCAM as a novel YAP (show YAP1 Antibodies) target in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) but not in breast and colon cancer cells. MCAM serum levels were specifically elevated in HCC (show FAM126A Antibodies) suggesting it as a specific diagnostic tool for HCC (show FAM126A Antibodies).

Mouse (Murine) Melanoma Cell Adhesion Molecule (MCAM) interaction partners

  1. Data show that CD146 was significantly higher expressed on tumor endothelium than on the liver.

  2. Conditional knockout of the cd146 gene in the murine endothelium or disruption of netrin-CD146 interaction by a specific anti-CD146 antibody blocks or reduces netrin-1 (show NTN1 Antibodies)-induced angiogenesis.

  3. MCAM is expressed by encephalitogenic CD8 (show CD8A Antibodies)+ T lymphocytes in experimental autoimmune encephalomyelitis. Blocking or depleting MCAM in vivo reduces chronic neurological deficits in active, transfer, and spontaneous progressive EAE models.

  4. Study demonstrate for the fi rst (show SLC22A12 Antibodies) time that host CD146 contributes to hematogenous melanoma cell metastasis through a novel mechanism involving the VEGF (show VEGFA Antibodies)/FAK (show PTK2 Antibodies)/Ve-cadherin (show CDH5 Antibodies) network.

  5. Suggest endothelial CD146 as a target for specific drug delivery in hepatocellular carcinoma.

  6. CD146 plays a dual role on endothelium, facilitating leukocyte extravasations and angiogenesis, thus promoting inflammation.

  7. CD146 deletion in the nervous system impairs appetite, locomotor activity and spatial learning in mice.

  8. Identified a novel negative regulator of angiogenesis, microRNA 329 (miR (show MLXIP Antibodies)-329), that directly targeted CD146 and inhibited CD146-mediated angiogenesis in vitro and in vivo.

  9. Alterations in CD146 are involved in the basic etiology of COPD (show ARCN1 Antibodies)/pulmonary emphysema.

  10. MUC18 exerts a proinflammatory function during lung bacterial infection.

Pig (Porcine) Melanoma Cell Adhesion Molecule (MCAM) interaction partners

  1. expression of FLK1 (show KDR Antibodies), CD146 and microvessel density of angiogenesis at the first week of reperfused acute myocardial infarction.

MCAM Antigen Profile

Protein Summary

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Gene names and symbols associated with MCAM

  • melanoma cell adhesion molecule (MCAM) antibody
  • melanoma cell adhesion molecule b (mcamb) antibody
  • similar to melanoma cell adhesion molecule (LOC566921) antibody
  • melanoma cell adhesion molecule (Mcam) antibody
  • 1-gicerin antibody
  • AV025631 antibody
  • CD146 antibody
  • CD149 antibody
  • gicerin antibody
  • id:ibd3512 antibody
  • MCAM antibody
  • Muc18 antibody
  • s-endo antibody
  • s-gicerin antibody

Protein level used designations for MCAM

cell surface glycoprotein MUC18 , melanoma adhesion molecule , cell adhesion molecule , similar to melanoma cell adhesion molecule , melanoma cell adhesion molecule , cell surface glycoprotein MUC18-like , Gicerin , S-endo 1 endothelial-associated antigen , cell surface glycoprotein P1H12 , melanoma-associated antigen A32 , melanoma-associated antigen MUC18 , HEMCAM , gicerin , l-gicerin protein , l-gicerin

GENE ID SPECIES
281301 Bos taurus
338313 Danio rerio
566921 Danio rerio
744688 Pan troglodytes
100071414 Equus caballus
100454353 Pongo abelii
100470323 Ailuropoda melanoleuca
4162 Homo sapiens
448832 Gallus gallus
84004 Mus musculus
489368 Canis lupus familiaris
78967 Rattus norvegicus
733617 Sus scrofa
100718224 Cavia porcellus
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