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Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Additionally we are shipping MCAM Proteins (28) and MCAM Kits (22) and many more products for this protein.
Showing 10 out of 304 products:
Human Monoclonal MCAM Primary Antibody for EIA, FACS - ABIN119672
Möbius-Winkler, Hilberg, Menzel, Golla, Burman, Schuler, Adams: Time-dependent mobilization of circulating progenitor cells during strenuous exercise in healthy individuals. in Journal of applied physiology (Bethesda, Md. : 1985) 2009
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Human Monoclonal MCAM Primary Antibody for IF, WB - ABIN968422
Anfosso, Bardin, Francès, Vivier, Camoin-Jau, Sampol, Dignat-George: Activation of human endothelial cells via S-endo-1 antigen (CD146) stimulates the tyrosine phosphorylation of focal adhesion kinase p125(FAK). in The Journal of biological chemistry 1998
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Human Polyclonal MCAM Primary Antibody for EIA, WB - ABIN453743
Malyszko, Malyszko, Kozminski, Pawlak, Mysliwiec: Adipokines, linking adipocytes and vascular function in hemodialyzed patients, may also be possibly related to CD146, a novel adhesion molecule. in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2008
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Human Monoclonal MCAM Primary Antibody for FACS, IHC - ABIN1724844
Wang, Yan: CD146, a multi-functional molecule beyond adhesion. in Cancer letters 2013
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Human Monoclonal MCAM Primary Antibody for IHC, ELISA - ABIN1724898
Jouve, Despoix, Espeli, Gauthier, Cypowyj, Fallague, Schiff, Dignat-George, Vély, Leroyer: The involvement of CD146 and its novel ligand Galectin-1 in apoptotic regulation of endothelial cells. in The Journal of biological chemistry 2013
Show all 2 references for ABIN1724898
Human Monoclonal MCAM Primary Antibody for EIA, FACS - ABIN119671
Kuzu, Bicknell, Fletcher, Gatter: Expression of adhesion molecules on the endothelium of normal tissue vessels and vascular tumors. in Laboratory investigation; a journal of technical methods and pathology 1993
Chicken Monoclonal MCAM Primary Antibody for FACS - ABIN371422
Vainio, Dunon, Aïssi, Dangy, McNagny, Imhof: HEMCAM, an adhesion molecule expressed by c-kit+ hemopoietic progenitors. in The Journal of cell biology 1997
CD146 regulates convergent extension movement during gastrulation
In addition to the physiological angiogenesis during development, gicerin morphants efficiently blocked the tumor angiogenesis in zebrafish.
CD146 protein expression has a role in vascular development in zebrafish
CD146 dexpression efines a subpopulation of human mesenchymal stem cells capable of bone formation and in vivo trans-endothelial migration.
Results showed that CD146 promoted metastasis of hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cells and predicted poor prognosis of HCC (show FAM126A Antibodies) patients. CD146 induced epithelial mesenchymal transition through probably IL-8 (show IL8 Antibodies) up-regulation and STAT1 (show STAT1 Antibodies) down-regulation.
Data indicate that CD146 antigen is an effective cell surface marker for enriching tumor-propagating cells (TPCs) in primary sarcomas.
MUC18 is an independent prognostic factor for clear cell renal cell carcinoma (show MOK Antibodies)
CD146 is a novel and useful marker for predicting senescence in human umbilical cord blood-derived Mesenchymal stem cells (hUCB-MSCs), and CD146 can potentially be applied in quality-control assessments of hUCB-MSC (show MSC Antibodies)-based therapy.
ZBTB7A (show ZBTB7A Antibodies) directly binds to the promoter and transcriptionally represses the expression of MCAM, establishing ZBTB7A (show ZBTB7A Antibodies) as a bona fide transcriptional repressor of MCAM
The expression of CD146 and HIF1a (show HIF1A Antibodies) was positively correlated with EGFR (show EGFR Antibodies) and CD31 (show HBA1 Antibodies), respectively in salivary gland adenoid cystic carcinoma.
a model that CD166 (show ALCAM Antibodies) regulates MCAM through a signaling flow from activation of PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and c-Raf (show RAF1 Antibodies)/MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) signaling to the inhibition of potential MCAM ubiquitin E3 ligases, betaTrCP (show BTRC Antibodies) and Smurf1 (show SMURF1 Antibodies)
Combined EpCAM (show EPCAM Antibodies)/MCAM CellSearch enrichment thus increased the CTC detection rate.
Results identified MCAM as a novel YAP (show YAP1 Antibodies) target in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) but not in breast and colon cancer cells. MCAM serum levels were specifically elevated in HCC (show FAM126A Antibodies) suggesting it as a specific diagnostic tool for HCC (show FAM126A Antibodies).
Data show that CD146 was significantly higher expressed on tumor endothelium than on the liver.
Conditional knockout of the cd146 gene in the murine endothelium or disruption of netrin-CD146 interaction by a specific anti-CD146 antibody blocks or reduces netrin-1 (show NTN1 Antibodies)-induced angiogenesis.
MCAM is expressed by encephalitogenic CD8 (show CD8A Antibodies)+ T lymphocytes in experimental autoimmune encephalomyelitis. Blocking or depleting MCAM in vivo reduces chronic neurological deficits in active, transfer, and spontaneous progressive EAE models.
Study demonstrate for the fi rst (show SLC22A12 Antibodies) time that host CD146 contributes to hematogenous melanoma cell metastasis through a novel mechanism involving the VEGF (show VEGFA Antibodies)/FAK (show PTK2 Antibodies)/Ve-cadherin (show CDH5 Antibodies) network.
Suggest endothelial CD146 as a target for specific drug delivery in hepatocellular carcinoma.
CD146 plays a dual role on endothelium, facilitating leukocyte extravasations and angiogenesis, thus promoting inflammation.
CD146 deletion in the nervous system impairs appetite, locomotor activity and spatial learning in mice.
Identified a novel negative regulator of angiogenesis, microRNA 329 (miR (show MLXIP Antibodies)-329), that directly targeted CD146 and inhibited CD146-mediated angiogenesis in vitro and in vivo.
Alterations in CD146 are involved in the basic etiology of COPD (show ARCN1 Antibodies)/pulmonary emphysema.
MUC18 exerts a proinflammatory function during lung bacterial infection.
expression of FLK1 (show KDR Antibodies), CD146 and microvessel density of angiogenesis at the first week of reperfused acute myocardial infarction.
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
cell surface glycoprotein MUC18
, melanoma adhesion molecule
, cell adhesion molecule
, similar to melanoma cell adhesion molecule
, melanoma cell adhesion molecule
, cell surface glycoprotein MUC18-like
, S-endo 1 endothelial-associated antigen
, cell surface glycoprotein P1H12
, melanoma-associated antigen A32
, melanoma-associated antigen MUC18
, l-gicerin protein