Melanoma Cell Adhesion Molecule Proteins (MCAM)

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Additionally we are shipping MCAM Antibodies (487) and MCAM Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MCAM 4162 P43121
MCAM 84004 Q8R2Y2
MCAM 78967 Q9EPF2
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Top MCAM Proteins at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human Fc Tag Human MCAM, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_Human Cells Human His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 20 to 21 Days
$272.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$576.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$656.00
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
$5,769.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details

MCAM Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , , , ,
Mouse (Murine) , ,
,
Rat (Rattus) ,
,

Top referenced MCAM Proteins

  1. Human MCAM Protein expressed in Human Cells - ABIN2002107 : Lehmann, Riethmüller, Johnson: MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. in Proceedings of the National Academy of Sciences of the United States of America 1990 (PubMed)
    Show all 6 references for 2002107

  2. Mouse (Murine) MCAM Protein expressed in Human Cells - ABIN2008310 : Shih: The role of CD146 (Mel-CAM) in biology and pathology. in The Journal of pathology 2000 (PubMed)
    Show all 4 references for 2008310

  3. Human MCAM Protein expressed in Wheat germ - ABIN1310514 : Simon, Martin, Smith, Thaikoottathil, Bowler, Barenkamp, Chu: Up-regulation of MUC18 in airway epithelial cells by IL-13: implications in bacterial adherence. in American journal of respiratory cell and molecular biology 2011 (PubMed)

  4. Human MCAM Protein expressed in HEK-293 Cells - ABIN2180692 : Elshal, Khan, Takahashi, Solomon, McCoy: CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood. in Blood 2005 (PubMed)

More Proteins for Melanoma Cell Adhesion Molecule (MCAM) Interaction Partners

Zebrafish Melanoma Cell Adhesion Molecule (MCAM) interaction partners

  1. In the context of adult zebrafish spinal cord injury, we proved that Melanoma cell adhesion molecule (MCAM) is beneficial to the recovery, possibly via mechanisms of angiogenensis and inflammation

  2. CD146 regulates convergent extension movement during gastrulation

  3. In addition to the physiological angiogenesis during development, gicerin morphants efficiently blocked the tumor angiogenesis in zebrafish.

  4. CD146 protein expression has a role in vascular development in zebrafish

Human Melanoma Cell Adhesion Molecule (MCAM) interaction partners

  1. MCAM promotes tamoxifen resistance by transcriptionally suppressing ERalpha (show ESR1 Proteins) expression and activating the AKT (show AKT1 Proteins) pathway, followed by induction of epithelial-mesenchymal transition.

  2. High MCAM expression is associated with lung metastasis in malignant melanoma.

  3. Results provide evidence that MUC18 promotes viral infections both in vivo and in vitro.

  4. soluble CD146 is released from the peripheral vasculature in response to venous stretch and may reflect systemic congestion in chronic heart failure patients

  5. CD146/MCAM is the functional galectin-3 (show LGALS3 Proteins)-binding ligand on endothelial cell surfaces responsible for galectin-3 (show LGALS3 Proteins)-induced secretion of metastasis-promoting cytokines.

  6. results indicate that CD146 can be targeted in vivo by the radiolabeled OI-3 antibodies

  7. Findings suggest that decreased CD146 expression in cancer-associated fibroblasts promotes pancreatic cancer progression.

  8. METCAM/MUC18 positively promotes tumorigenesis of human breast cancer SK-BR-3 cells via increasing the signal in survival and proliferation pathways.

  9. sCD146 levels are elevated in patients with systemic sclerosis, but decreased sCD146 levels are observed in SSc (show CYP11A1 Proteins) patients with pulmonary arterial hypertension

  10. Nestin (show NES Proteins) and CD146 are expressed in breast cancer cells with highly aggressive potency. They might contribute to disease relapse in breast cancer by activating the epithelial-mesenchymal transition pathway and assist tumor neovascularization.

Mouse (Murine) Melanoma Cell Adhesion Molecule (MCAM) interaction partners

  1. Results provide evidence that MUC18 promotes viral infections both in vivo and in vitro.

  2. Microphthalmia-associated transcription factor (show MITF Proteins) regulates skin melanoblast migration by repressing the melanoma cell adhesion molecule

  3. Data show that CD146 was significantly higher expressed on tumor endothelium than on the liver.

  4. Conditional knockout of the cd146 gene in the murine endothelium or disruption of netrin-CD146 interaction by a specific anti-CD146 antibody blocks or reduces netrin-1 (show NTN1 Proteins)-induced angiogenesis.

  5. MCAM is expressed by encephalitogenic CD8 (show CD8A Proteins)+ T lymphocytes in experimental autoimmune encephalomyelitis. Blocking or depleting MCAM in vivo reduces chronic neurological deficits in active, transfer, and spontaneous progressive EAE models.

  6. Study demonstrate for the fi rst (show SLC22A12 Proteins) time that host CD146 contributes to hematogenous melanoma cell metastasis through a novel mechanism involving the VEGF (show VEGFA Proteins)/FAK (show PTK2 Proteins)/Ve-cadherin (show CDH5 Proteins) network.

  7. Suggest endothelial CD146 as a target for specific drug delivery in hepatocellular carcinoma.

  8. CD146 plays a dual role on endothelium, facilitating leukocyte extravasations and angiogenesis, thus promoting inflammation.

  9. CD146 deletion in the nervous system impairs appetite, locomotor activity and spatial learning in mice.

  10. Identified a novel negative regulator of angiogenesis, microRNA 329 (miR (show MLXIP Proteins)-329), that directly targeted CD146 and inhibited CD146-mediated angiogenesis in vitro and in vivo.

Pig (Porcine) Melanoma Cell Adhesion Molecule (MCAM) interaction partners

  1. expression of FLK1 (show KDR Proteins), CD146 and microvessel density of angiogenesis at the first week of reperfused acute myocardial infarction.

MCAM Protein Profile

Protein Summary

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Gene names and symbols associated with MCAM

  • melanoma cell adhesion molecule (MCAM)
  • melanoma cell adhesion molecule b (mcamb)
  • similar to melanoma cell adhesion molecule (LOC566921)
  • melanoma cell adhesion molecule (Mcam)
  • 1-gicerin protein
  • AV025631 protein
  • CD146 protein
  • CD149 protein
  • gicerin protein
  • id:ibd3512 protein
  • MCAM protein
  • Muc18 protein
  • s-endo protein
  • s-gicerin protein

Protein level used designations for MCAM

cell surface glycoprotein MUC18 , melanoma adhesion molecule , cell adhesion molecule , similar to melanoma cell adhesion molecule , melanoma cell adhesion molecule , cell surface glycoprotein MUC18-like , Gicerin , S-endo 1 endothelial-associated antigen , cell surface glycoprotein P1H12 , melanoma-associated antigen A32 , melanoma-associated antigen MUC18 , HEMCAM , gicerin , l-gicerin protein , l-gicerin

GENE ID SPECIES
281301 Bos taurus
338313 Danio rerio
566921 Danio rerio
744688 Pan troglodytes
100071414 Equus caballus
100454353 Pongo abelii
100470323 Ailuropoda melanoleuca
4162 Homo sapiens
448832 Gallus gallus
84004 Mus musculus
489368 Canis lupus familiaris
78967 Rattus norvegicus
733617 Sus scrofa
100718224 Cavia porcellus
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