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Melanoma Inhibitory Activity Family, Member 3 Proteins (MIA3)

Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. Additionally we are shipping MIA3 Antibodies (14) and MIA3 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MIA3 338366 Q8BI84
MIA3 375056 Q5JRA6
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Top MIA3 Proteins at antibodies-online.com

Showing 2 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details

MIA3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human

More Proteins for Melanoma Inhibitory Activity Family, Member 3 (MIA3) Interaction Partners

Fruit Fly (Drosophila melanogaster) Melanoma Inhibitory Activity Family, Member 3 (MIA3) interaction partners

  1. PGANT4 is an O-glycosyltransferase (show OGT Proteins) that functions as a regulator of secretion and secretory vesicle formation in vivo by glycosylating the essential Golgi/endoplasmic reticulum protein (show PDIA3 Proteins), Tango1 and conferring protection from furin (show FURIN Proteins)-mediated proteolysis

  2. identifed a mechanism for polarized basement membrane(BM)secretion in follicle cells; BM proteins are synthesized in a basal ER compartment and exported through Tango1-positive ER exit sites to basal Golgi clusters; Crag (show AGAP3 Proteins) targets Rab10 (show RAB10 Proteins) to structures in the basal cytoplasm, where it restricts protein delivery to the basal surface

  3. Study provides evidence that TANGO1 is an integral membrane protein localized to endoplasmic reticulum (ER) exit sites, with a luminal SH3 domain and a cytoplasmic proline-rich domain (PRD).

Mouse (Murine) Melanoma Inhibitory Activity Family, Member 3 (MIA3) interaction partners

  1. Mia3's role in protein secretion is much broader than previously realized, and it may, in fact, be required for the efficient secretion of all collagen molecules in higher organisms

  2. revealed very broad TANGO expression patterns in contrast to the highly restricted expression patterns previously determined for the other members of the MIA (show MIA Proteins) gene family

Human Melanoma Inhibitory Activity Family, Member 3 (MIA3) interaction partners

  1. TANGO1 is thus pivotal in concentrating procollagen VII (show TH Proteins) in the lumen and recruiting ERGIC membranes on the cytoplasmic surface of the endoplasmic reticulum.

  2. TANGO (show ARNT Proteins) expression was strongly associated with tumour progression, nodal metastasis, clinical stage and number of blood or lymph vessels in oral squamous cell carcinoma.

  3. We conclude that SNP rs17465637 in MIA3 is indeed a genetic risk factor for CAD across different ethnic populations including Han Chinese.

  4. results suggest a potential association of the MIA3 rs17465637 with cardiovascular disease in dyslipidemic patients with rheumatoid arthritis

  5. TANGO (show ARNT Proteins) transfected cell lines revealed that TANGO (show ARNT Proteins) expression reduces motility, whereas reduction of TANGO (show ARNT Proteins) enhances migration.

  6. The results from this study present TANGO (show ARNT Proteins) as a novel ligand for CD11c (show ITGAX Proteins), regulating migratory processes of hematopoietic cells.

  7. Reduced expression of TANGO (show ARNT Proteins) is associated with colon and hepatocellular carcinomas

MIA3 Protein Profile

Protein Summary

Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. May participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1 (By similarity).

Gene names and symbols associated with MIA3

  • Transport and Golgi organization 1 (Tango1)
  • melanoma inhibitory activity family, member 3 (MIA3)
  • melanoma inhibitory activity family, member 3 (mia3)
  • melanoma inhibitory activity 3 (Mia3)
  • 9130229H14Rik protein
  • A930039G15Rik protein
  • ARNT protein
  • AU022327 protein
  • B230399H06Rik protein
  • C80126 protein
  • CG11098 protein
  • D320 protein
  • Dmel\\CG11098 protein
  • Gm1525 protein
  • MIA3 protein
  • TANGO protein
  • TANGO1 protein
  • UNQ6077 protein

Protein level used designations for MIA3

CG11098-PA , CG11098-PC , Tango1-PA , Tango1-PC , transport and golgi organisation 1 , transport and golgi organization 1 , melanoma inhibitory activity family, member 3 , melanoma inhibitory activity protein 3-like , melanoma inhibitory activity protein 3 , transport and Golgi organization protein 1 , C219 reactive peptide , C219-reactive peptide , TANGO1

GENE ID SPECIES
33930 Drosophila melanogaster
421337 Gallus gallus
457757 Pan troglodytes
478997 Canis lupus familiaris
704405 Macaca mulatta
100024966 Monodelphis domestica
100055507 Equus caballus
100351527 Oryctolagus cuniculus
100379945 Xenopus (Silurana) tropicalis
100450028 Pongo abelii
100479797 Ailuropoda melanoleuca
100580164 Nomascus leucogenys
338366 Mus musculus
375056 Homo sapiens
509133 Bos taurus
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