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Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. Additionally we are shipping MIA3 Proteins (4) and MIA3 Kits (2) and many more products for this protein.
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PGANT4 is an O-glycosyltransferase (show OGT Antibodies) that functions as a regulator of secretion and secretory vesicle formation in vivo by glycosylating the essential Golgi/endoplasmic reticulum protein (show PDIA3 Antibodies), Tango1 and conferring protection from furin (show FURIN Antibodies)-mediated proteolysis
identifed a mechanism for polarized basement membrane(BM)secretion in follicle cells; BM proteins are synthesized in a basal ER compartment and exported through Tango1-positive ER exit sites to basal Golgi clusters; Crag (show AGAP3 Antibodies) targets Rab10 (show RAB10 Antibodies) to structures in the basal cytoplasm, where it restricts protein delivery to the basal surface
Study provides evidence that TANGO1 is an integral membrane protein localized to endoplasmic reticulum (ER) exit sites, with a luminal SH3 domain (show ITSN1 Antibodies) and a cytoplasmic proline-rich domain (PRD (show PRD Antibodies)).
Mia3's role in protein secretion is much broader than previously realized, and it may, in fact, be required for the efficient secretion of all collagen molecules in higher organisms
revealed very broad TANGO expression patterns in contrast to the highly restricted expression patterns previously determined for the other members of the MIA (show MIA Antibodies) gene family
Mammalian endoplasmic reticulum exit sites are organized by TANGO1 acting as a scaffold, in cooperation with Sec16 for efficient secretion.
TANGO1 is thus pivotal in concentrating procollagen VII (show TH Antibodies) in the lumen and recruiting ERGIC membranes on the cytoplasmic surface of the endoplasmic reticulum.
TANGO (show ARNT Antibodies) expression was strongly associated with tumour progression, nodal metastasis, clinical stage and number of blood or lymph vessels in oral squamous cell carcinoma.
We conclude that SNP rs17465637 in MIA3 is indeed a genetic risk factor for CAD across different ethnic populations including Han Chinese.
results suggest a potential association of the MIA3 rs17465637 with cardiovascular disease in dyslipidemic patients with rheumatoid arthritis
TANGO (show ARNT Antibodies) transfected cell lines revealed that TANGO (show ARNT Antibodies) expression reduces motility, whereas reduction of TANGO (show ARNT Antibodies) enhances migration.
The results from this study present TANGO (show ARNT Antibodies) as a novel ligand for CD11c (show ITGAX Antibodies), regulating migratory processes of hematopoietic cells.
Reduced expression of TANGO (show ARNT Antibodies) is associated with colon and hepatocellular carcinomas
Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. May participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1 (By similarity).
, transport and golgi organisation 1
, transport and golgi organization 1
, melanoma inhibitory activity family, member 3
, melanoma inhibitory activity protein 3-like
, melanoma inhibitory activity protein 3
, transport and Golgi organization protein 1
, C219 reactive peptide
, C219-reactive peptide